Development of an in vitro cell culture model of hepatic steatosis using hepatocyte-derived reporter cells

Biotechnology and Bioengineering

Volumn 102, Issue 5, 2009, Pages 1466-1474

  Janorkar, Amol V ^a,b   King, Kevin R ^a   Megeed, Zaki ^a   Yarmush, Martin L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

In vitro disease model; Reporter cells; Steatosis

Indexed keywords

APOPTOTIC; CYTOKINE; DOSE DEPENDENTS; FATTY LIVER DISEASE; GREEN FLUORESCENT PROTEINS; HEAT SHOCK RESPONSE; HEPATIC INJURIES; HEPATIC STEATOSIS; HEPATOCYTE; HUMAN DISEASE; IN VITRO DISEASE MODEL; LIVING CELLS; MITOCHONDRIAL MEMBRANE POTENTIALS; MOLECULAR MECHANISMS; NUCLEAR FACTOR-KB; REACTIVE OXYGEN SPECIES; REPORTER CELLS; RESPONSE ELEMENTS; STEATOSIS; TRANSCRIPTIONAL REGULATIONS; TRANSCRIPTIONAL RESPONSE;

ANIMAL CELL CULTURE; CELL MEMBRANES; DYNAMICS; ENZYME INHIBITION; FATTY ACIDS; LIVER; OXYGEN;

CELL CULTURE;

CYTOKINE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL STRESS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE COURSE; DNA RESPONSIVE ELEMENT; FATTY ACID TRANSPORT; FATTY LIVER; FLOW CYTOMETRY; HEAT SHOCK RESPONSE; LIVER CELL CULTURE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; RAT; TRANSCRIPTION REGULATION;

CELLS, CULTURED; FATTY LIVER; GENE EXPRESSION PROFILING; HEPATOCYTES; HUMANS; LIPID METABOLISM; MODELS, BIOLOGICAL;

EID: 63549141896     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22191     Document Type: Article

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