Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin 5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs

Journal of Biomedical Science

Volumn 16, Issue 1, 2009, Pages

  Liang, Chih Chia ^a   You, Li Ru ^a   Chang, Junn Liang ^b   Tsai, Ting Fen ^a   Chen, Chun Ming ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAOYUAN ARMED FORCES GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; CYTOKERATIN 5; 4 HYDROXYTAMOXIFEN; 4-HYDROXYTAMOXIFEN; ANTIESTROGEN; DRUG DERIVATIVE; ESTROGEN RECEPTOR; HYBRID PROTEIN; INTEGRASE; TAMOXIFEN;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CONTROLLED STUDY; DNA MODIFICATION; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INDUCTION; EPITHELIUM BASAL CELL; MOUSE; NONHUMAN; PERINATAL DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE; ANIMAL; ANIMAL EMBRYO; C57BL MOUSE; CATTLE; CYTOLOGY; EPITHELIUM CELL; FEMALE; GENE TARGETING; GENETICS; HISTOLOGY; MALE; METABOLISM; PHYSIOLOGY; TISSUE DISTRIBUTION;

BOVINAE; MUS; MUS MUSCULUS;

ANIMALS; CATTLE; EMBRYO, MAMMALIAN; EPITHELIAL CELLS; ESTROGEN ANTAGONISTS; FEMALE; GENE TARGETING; INTEGRASES; KERATIN-5; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; TAMOXIFEN; TISSUE DISTRIBUTION;

EID: 63449126897     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-16-2     Document Type: Article

References (28)

1. Gene-targeting strategies. SS Cheah RR Behringer, Methods Mol Biol 2000 136 455 463 10840733
2. Conditional alleles in mice: practical considerations for tissue-specific knockouts. KM Kwan, Genesis 2002 32 49 62 10.1002/gene.10068 11857777
3. Ligand-activated site-specific recombination in mice. R Feil J Brocard B Mascrez M LeMeur D Metzger P Chambon, Proc Natl Acad Sci USA 1996 93 10887 10890 8855277 10.1073/pnas.93.20.10887
4. A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. M Vooijs J Jonkers A Berns, EMBO Rep 2001 2 292 297 11306549 10.1093/embo-reports/kve064
5. Sequence and expression of a type II keratin, K5, in human epidermal cells. R Lersch E Fuchs, Mol Cell Biol 1988 8 486 493 2447486
6. The 50- and 58-kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies. WG Nelson TT Sun, J Cell Biol 1983 97 244 251 6190820 10.1083/jcb.97.1.244
7. Analysis of the control of expression and tissue specificity of the keratin 5 gene, characteristic of basal keratinocytes. Fundamental role of an AP-1 element. J Casatorres JM Navarro M Blessing JL Jorcano, J Biol Chem 1994 269 20489 20496 7519609
8. Programming gene expression in developing epidermis. C Byrne M Tainsky E Fuchs, Development 1994 120 2369 2383 7525178
9. Sequences 5' of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development. A Ramirez A Bravo JL Jorcano M Vidal, Differentiation 1994 58 53 64 7532601
10. Mechanisms regulating epithelial stratification. MI Koster DR Roop, Annu Rev Cell Dev Biol 2007 23 93 113 10.1146/annurev.cellbio.23.090506.123357 17489688
11. Epidermal stem cells of the skin. C Blanpain E Fuchs, Annu Rev Cell Dev Biol 2006 22 339 373 16824012 10.1146/annurev.cellbio.22.010305.104357
12. Scratching the surface of skin development. E Fuchs, Nature 2007 445 834 842 17314969 10.1038/nature05659
13. Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. M Hafner J Wenk A Nenci M Pasparakis K Scharffetter-Kochanek N Smyth T Peters D Kess O Holtkotter P Shephard JE Kudlow H Smola I Haase A Schippers T Krieg W Muller, Genesis 2004 38 176 181 10.1002/gene.20016 15083518
14. A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination. A Ramirez A Page A Gandarillas J Zanet S Pibre M Vidal L Tusell A Genesca DA Whitaker DW Melton JL Jorcano, Genesis 2004 39 52 57 10.1002/gene.20025 15124227
15. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. V Vasioukhin L Degenstein B Wise E Fuchs, Proc Natl Acad Sci USA 1999 96 8551 8556 10411913 10.1073/pnas.96.15.8551
16. Characterization of an inducible, epidermal-specific knockout system: differential expression of lacZ in different Cre reporter mouse strains. TR Berton XJ Wang Z Zhou C Kellendonk G Schutz S Tsai DR Roop, Genesis 2000 26 160 161 10.1002/(SICI)1526-968X(200002)26:2<160::AID-GENE20>3.0.CO;2-# 10686618
17. In utero activation of K5.CrePR1 induces gene deletion. Z Zhou D Wang XJ Wang DR Roop, Genesis 2002 32 191 192 10.1002/gene.10064 11857819
18. Targeted somatic mutagenesis in mouse epidermis. AK Indra M Li J Brocard X Warot JM Bornert C Gerard N Messaddeq P Chambon D Metzger, Horm Res 2000 54 296 300 10.1159/000053275 11595821
19. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. AK Indra X Warot J Brocard JM Bornert JH Xiao P Chambon D Metzger, Nucleic Acids Res 1999 27 4324 4327 10536138 10.1093/nar/27.22.4324
20. Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities. F Recillas-Targa MJ Pikaart B Burgess-Beusse AC Bell MD Litt AG West M Gaszner G Felsenfeld, Proc Natl Acad Sci USA 2002 99 6883 6888 12011446 10.1073/pnas.102179399
21. Recruitment of histone modifications by USF proteins at a vertebrate barrier element. AG West S Huang M Gaszner MD Litt G Felsenfeld, Mol Cell 2004 16 453 463 10.1016/j.molcel.2004.10.005 15525517
22. Manipulating the mouse embryo: a laboratory manual. A Nagy M Gertsenstein K Vintersten RR Behringer, New York: Cold Spring Harbor Laboratory Press 3 2003 289 331 12929582
23. Tumor Spectrum, Tumor Latency and Tumor Incidence of the Pten-Deficient Mice. T-L Lu J-L Chang C-C Liang L-R You C-M Chen, PLoS ONE 2007 2 e1237 18043744 10.1371/journal.pone.0001237
24. Generalized lacZ expression with the ROSA26 Cre reporter strain. P Soriano, Nat Genet 1999 21 70 71 10.1038/5007 9916792
25. Identification and characterization of thymic epithelial progenitor cells. AR Bennett A Farley NF Blair J Gordon L Sharp CC Blackburn, Immunity 2002 16 803 814 10.1016/S1074-7613(02)00321-7 12121662
26. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. DB Klug C Carter E Crouch D Roop CJ Conti ER Richie, Proc Natl Acad Sci USA 1998 95 11822 11827 9751749 10.1073/pnas.95.20.11822
27. Epithelial-stromal tissue interaction in paramesonephric (Mullerian) epithelial differentiation. T Kurita PS Cooke GR Cunha, Dev Biol 2001 240 194 211 10.1006/dbio.2001.0458 11784056
28. Stromal induction and specification of morphogenesis and cytodifferentiation of the epithelia of the Mullerian ducts and urogenital sinus during development of the uterus and vagina in mice. GR Cunha, J Exp Zool 1976 196 361 370 10.1002/jez.1401960310 932664