Engineering a G protein-coupled receptor for structural studies: stabilization of the BLT1 receptor ground state

Protein Science

Volumn 18, Issue 4, 2009, Pages 727-734

  Martin, Aimee ^a   Damian, Marjorie ^a   Laguerre, Michel ^b   Parello, Joseph ^c   Pucci, Bernard ^d   Serre, Laurence ^e,f   Mary, Sophie ^a   Marie, Jacky ^a   Baneres, Jean Louis ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b CNRS   (France)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF AVIGNON   (France)

^e INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^f Faculté de Pharmacie Bât ^*  (France)

Author keywords

Activation; GPCR: G protein; Stability; Structure

Indexed keywords

DETERGENT; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HISTIDINE; LEUKOTRIENE B4 RECEPTOR; MUTANT PROTEIN; PROTEIN BLT 1; RECEPTOR PROTEIN; UNCLASSIFIED DRUG; ZINC ION;

ARTICLE; BINDING AFFINITY; BINDING SITE; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY; WILD TYPE;

EID: 63449123226     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.55     Document Type: Article

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