Organ preservation in locally advanced head and neck cancer of the larynx using induction chemotherapy followed by improved radiation schemes

European Archives of Oto-Rhino-Laryngology

Volumn 266, Issue 5, 2009, Pages 719-726

  Franchin, Giovanni ^a   Vaccher, Emanuela ^a   Politi, Doriano ^b   Minatel, Emilio ^a   Gobitti, Carlo ^a   Talamini, Renato ^a   Spazzapan, Simon ^a   Savignano, Maria Gabriella ^b   Trovò, Mauro G ^a   Barzan, Luigi ^b  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b S Maria Degli Angeli Regional Hospital   (Italy)

Author keywords

Intensive chemotherapy; Larynx; Organ preservation; Phase II study; Unconventional radiotherapy

Indexed keywords

CISPLATIN; FLUOROURACIL;

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER RELAPSE; CANCER SURVIVAL; CARDIOTOXICITY; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CLINICAL FEATURE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTINUOUS INFUSION; DEHYDRATION; DERMATITIS; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DISTANT METASTASIS; DRUG DOSE REDUCTION; ELECTROLYTE DISTURBANCE; FEMALE; HEAD AND NECK CANCER; HEART MUSCLE ISCHEMIA; HUMAN; HYPOPHARYNX CARCINOMA; LARYNX CARCINOMA; LARYNX EDEMA; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; OROPHARYNX CARCINOMA; OTITIS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; SINUS BRADYCARDIA; SQUAMOUS CELL CARCINOMA; TACHYCARDIA; THROMBOCYTOPENIA; TREATMENT RESPONSE;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; SALVAGE THERAPY;

EID: 63449101849     PISSN: 09374477     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00405-008-0798-2     Document Type: Article

References (33)

1. No authors listed (1991) Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer: the Department of Veteran Affairs Laryngeal Cancer Study Group. N Engl J Med 324(24):1685-1690
2. JL Lefebvre D Chevalier B Luboinski 1996 Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial: EORTC Head and Neck Cancer Cooperative Group J Natl Cancer Inst 88 890 899 10.1093/jnci/88.13.890
3. G Franchin E Vaccher C Gobitti 2005 Neoadjuvant accelerated chemotherapy followed by hyperfractionated radiation therapy in patients with operable, locally advanced head and neck carcinoma Oral Oncol 41 526 533 10.1016/j.oraloncology.2004.12.013
4. KK Fu TF Pajak A Trotti 2000 A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas; first report of RTOG 9003 Int J Radiat Oncol Biol Phys 48 1 7 16 10.1016/S0360-3016(00)00663-5
5. EL Kaplan P Meier 1958 Non-parametric estimation from incomplete observations J Am Stat Assoc 53 457 481 10.2307/2281868
6. International Histological Classification of Tumors (1967-1981). vol 1-25. World Health Organization. Geneva
7. EE Cohen MW Lingen EE Vokes 2004 The expanding role of systemic therapy in head and neck cancer J Clin Oncol 22 1743 1752 10.1200/JCO.2004.06.147
8. A Paccagnella A Orlando C Marchiori 1994 Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppo di Studio sui Tumori della Testa e del Collo J Natl Cancer Inst 86 265 272 10.1093/jnci/86.4.265
9. JP Pignon J Bourhis C Domenge L Designe MACH-NC Collaborative Group 2000 Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data Lancet 355 949 955
10. M Merlano M Benasso R Corvo 1996 Five-year update of a randomized trial of alternating radiotherapy and chemotherapy ccompared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck J Natl Cancer Inst 88 9 583 589 10.1093/jnci/88.9.583
11. Forastiere AA, Maor M, Weber RS, et al (2006) ASCO Annual Meeting Proceedings Part 1. J Clin Oncol 24 (18S):5517
12. GE Laramore CB Scott M Al-Sarraf 1992 Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: report on Intergroup Study 0034 Int J Radiat Oncol Biol Phys 23 705 713
13. DE Sculler B Metch D Mattox 1988 Preoperative chemotherapy in advanced respectable head and neck cancer: final report of the Southwest Oncology Group Laryngoscope 98 1205 1211
14. Jensen AR, Nellemann H, Overgaard J (2006) Growth of H/N carcinoma during waiting time for radical treatment (051); oral presentation. 3rd World Congress of the International Federation of Head/Neck Oncologic Societies. Prague, Czech Republic. June 27-July 1 2006
15. AR Jensen HM Nellemann J Overgaard 2007 Tumor progression in waiting time for radiotherapy in head and neck cancer Radiother Oncol 84 1 5 10 10.1016/j.radonc.2007.04.001
16. A Waaijer CH Terhaard H Dehnad 2003 Waiting times for radiotherapy: consequences of volume increase for the TCP in oropharyngeal carcinoma Radiother Oncol 66 3 271 276 10.1016/S0167-8140(03)00036-7
17. AA Forastiere H Goepfert M Maor 2003 Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer N Engl J Med 349 2091 2098 10.1056/NEJMoa031317
18. DJ Adelstein VM Sharan AS Earle 1990 Simultaneous versus sequential combined technique therapy for squamous cell head and neck cancer Cancer 65 1685 1691 10.1002/1097-0142(19900415)65:8<1685::AID-CNCR2820650804>3.0.CO;2-S
19. G Calais M Alfonsi E Bardet 1999 Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma J Natl Cancer Inst 91 2081 2086 10.1093/jnci/91.24.2081
20. DJ Adelstein JP Saxton P Lavertu 2002 Maximizing local control and organ preservation in stage IV squamous cell head and neck cancer with hyperfractionated radiation and concurrent chemotherapy J Clin Oncol 20 5 1405 1410 10.1200/JCO.20.5.1405
21. DJ Adelstein JP Saxton LA Rybicki 2006 Multi-agent concurrent chemoradiotherapy for locoregionally advanced squamous cell head and neck cancer: mature results from a single institution J Clin Oncol 24 1064 1071 10.1200/JCO.2005.01.5867
22. DM Brizel ME Albers SR Fisher 1998 Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced Head and Neck cancer N Engl J Med 338 25 1798 1804 10.1056/NEJM199806183382503
23. F Denis P Garaud E Bardet 2004 Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced stage oropharynx carcinoma J Clin Oncol 22 69 76 10.1200/JCO.2004.08.021
24. B Jeremic B Milicic A Dagovic 2004 Radiation therapy with or without concurrent low-dose daily chemotherapy in locally advanced, non-metastatic squamous cell carcinoma of the head and neck J Clin Oncol 22 17 3540 3548 10.1200/JCO.2004.10.076
25. M Machtay DI Rosenthal D Hershock 2002 Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: a Univ. of Pennsylvania Phase II trial J Clin Oncol 19 20 3964 3971 10.1200/JCO.2002.11.026
26. JD Hainsworth AA Meluch S McClurkan 2002 Induction paclitaxel, carboplatin, and infusional 5 FU followed by concurrent radiation therapy and weekly paclitaxel/carboplatin in the treatment of locally advanced head and neck cancer: a phase II trial of the Minnie Pearl Cancer Research Network Cancer J 8 4 311 321 10.1097/00130404-200207000-00007
27. EE Vokes K Stenson FR Rosen 2003 Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hyroxyurea chemoradiotherapy: curative and organ-preserving therapy for advanced head and neck cancer J Clin Oncol 21 320 326 10.1200/JCO.2003.06.006
28. A Psyrri M Kwong S DiStasio 2004 Cisplatin, fluorouracil, and leucovorin induction chemotherapy followed by concurrent cisplatin chemoradiotherapy for organ preservation and cure in patients with advanced head and neck cancer: long term follow-up J Clin Oncol 22 3061 3069 10.1200/JCO.2004.01.108
29. B Guadagnolo R Haddad M Posner 2005 Organ preservation and treatment toxicity with induction chemotherapy followed by radiation therapy or chemoradiation for advanced laryngeal cancer Am J Clin Oncol 28 4 371 378 10.1097/01.coc.0000162423.13431.8d
30. M Posner D Hershock C Blajman TAX 324 Study Group 2007 Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer N Engl J Med 357 17 1705 1715 10.1056/NEJMoa070956
31. KK Ang J Harris AS Garden 2005 Concomitant boost radiation plus concurrent cisplatin for advanced head and neck carcinomas: radiation therapy oncology group phase II trial 99-14 J Clin Oncol 23 13 3008 3015 10.1200/JCO.2005.12.060
32. S Urba G Wolf A Eisbruch 2006 Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: a new treatment paradigm J Clin Oncol 24 4 593 598 10.1200/JCO.2005.01.2047
33. JA Bonner PM Harari J Giralt 2006 Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck N Engl J Med 354 6 567 578 10.1056/NEJMoa053422