The hemicellulose preparation, natramune™ (PDS-2865)®, increases macrophage phagocytosis and nitric oxide production and increases circulating human lymphocytes levels

Medical Science Monitor

Volumn 15, Issue 2, 2009, Pages

  Weeks, Benjamin S ^a   Perez, Pedro P ^b,c  

^a ADELPHI UNIVERSITY   (United States)

^b Innovation Laboratories Inc   (United States)

^c NONE   (United States)

Author keywords

Cell proliferation; Hemicellulose; Natramune (PDS 2865); Nitric oxide; Phagocytosis; Supplementation

Indexed keywords

HEMICELLULOSE; LEVAMISOLE; NATRAMUNE; NITRIC OXIDE; NITRITE; PDS 2865; UNCLASSIFIED DRUG; POLYSACCHARIDE;

ADULT; AGED; ANIMAL CELL; ARTICLE; CASE REPORT; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EVENING DOSAGE; HUMAN; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MACROPHAGE FUNCTION; MORNING DOSAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; ADOLESCENT; ANIMAL; BIOSYNTHESIS; CELL COUNT; CELL MOTION; CELL SURVIVAL; CLINICAL TRIAL; CYTOLOGY; IMMUNE SYSTEM; IMMUNOLOGY; LYMPHOCYTE; MACROPHAGE; MIDDLE AGED;

ADOLESCENT; ADULT; AGED; ANIMALS; CELL COUNT; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; IMMUNE SYSTEM; LYMPHOCYTES; MACROPHAGES; MICE; MIDDLE AGED; NITRIC OXIDE; PHAGOCYTOSIS; POLYSACCHARIDES;

EID: 63449090754     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Ghoneum M, Matsuura M: Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran). IntJ Immunopathol Pharmacol, 2004; 17(3): 283-92
2. Ghoneum M, Jewett: Production of tumor necrosis factor-alpha and in- terferon-gamma from human peripheral blood lymphocytes by MGN- 3, a modified arabinoxylan from rice bran, and its synergy with inter- leukin-2 in vitro. Cancer Detect Prev, 2000; 24(4): 314-24 '
3. Choi EM, Kim AJ, Kim YO, Hwang JK Immunomodulating activity of ara- binogalactan and fucoidan in vitro. J Med Food, 2005; 8(4): 446-53
4. Ghoneum M: Anti-HIV activity in vitro of MGN-3, an activated arabinox- ylane from rice bran. Biochem Biophys Res Commun, 1998; 243(1): 25-29
5. Kiyohara H, Matsumoto T, Yamada H: Intestinal immune system modulating polysaccharides in a Japanese herbal (Kampo) medicine, Juzen-Taiho-To. Phytomedicine, 2002; 9(7): 614-24
6. Kiyohara H, Matsumoto T, Yamada H: Combination effects of herbs in a multi-herbal formula: expression ofJuzen-Taiho-To's immuno-modula- tory activity on the intestinal immune system. Evid Based Complement Alternat Med, 2004; 1(1): 83-91
7. Kamiyama H, Takano S, Ishikawa E et al: Anti-angiogenic and immunomodulatory effect of the herbal medicine "Juzen-Taiho-To" on malignant glioma. Biol Pharm Bull, 2005; 28(11): 2111-16
8. Chavoustie SE, Perez PP, Fletcher MA et al: Pilot Study: Effect of PDS-2865 on natural killer cell cytotoxicty. JANA, 2003; 6(2): 39-42
9. Weeks BS, Lee SW, Perez PP et al: Natramune (PDS-2865) and PureWay- C reduce xenobiotic-induced human T-cell a5|31 integrin-mediated adhesion to fibronectin. Med Sci Monit, 2008; 14(12): BR279-85
10. Stuehr DJ, Gross SS, Sakuma I et al: Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-de- rived relaxing factor and the chemical reactivity of nitric oxide. J Exp Med. 1989; 169(3): 1011-20
11. Kogishi JI, Akimoto M, Mandai M et al: Nitric oxide as a second messenger in phagocytosis by cultured retinal pigment epithelial cells. Ophthalmic Res, 2000; 32(4): 138-42
12. Cai P, Kaphalia BS, Ansari GA: Methyl palmitate: inhibitor of phagocytosis in primary rat Kupffer cells. Toxicology, 2005; 210(2-3): 197-204
13. Calderon C, Huang ZH, Gage DA et al: Isolation of a nitric oxide inhibitor from mammary tumor cells and its characterization as phosphatidyl serine. J Exp Med, 1994; 180(3): 945-58
14. Stefano GB, Cadet P, Fimiani C, Magazine HI: Morphine stimulates iNOS expression via a rebound from inhibition in human macrophages: nitric oxide involvement. Int J Immunopathol Pharmacol, 200; 14(3): 129-38
15. Tripathi P: Nitric oxide and immune response. Indian J Biochem Biophys, 2007; 44(5): 310-19
16. Kodali VP, Sen R: Antioxidant and free radical scavenging activities of an exopolysaccharide from a probiotic bacterium. Biotechnol J, 2008; 3(2): 245-51
17. Gregory PJ, Sperry M, Wilson AF: Dietary supplements for osteoarthritis. Am Fam Physician, 2008; 77(2): 177-84
18. Falk R, Grunwald J, Hoffman A et al: Distribution of amphotericin B-arabinogalactan conjugate in mouse tissue and its therapeutic efficacy against murine aspergillosis. Antimicrob Agents Chemother, 2004; 48(9): 3606-9
19. Parveen S, Gupta AD, Prasad R: Arabinogalactan protein from Arachis hypogaea: role as carrier in drug-formulations. Int J Pharm, 2007; 333(1-2): 79-86
20. Falk R, Hacham M, Nyska A et al: Induction of interleukin-1beta, tumour necrosis factor-alpha and apoptosis in mouse organs by amphotericin B is neutralized by conjugation with arabinogalactan. J Antimicrob Chemother, 2005; 55(5): 713-20