Genetically engineered attenuated measles virus specifically infects and kills primary multiple myeloma cells

Journal of General Virology

Volumn 90, Issue 3, 2009, Pages 693-701

  Hummel, Horst Dieter ^a   Kuntz, Gabriele ^a   Russell, Stephen J ^b   Nakamura, Takafumi ^b   Greiner, Axel ^c   Einsele, Hermann ^a   Topp, Max S ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY WUE 1; ONCOLYTIC MEASLES VIRUS; ONCOLYTIC VIRUS; SYNDECAN 1; UNCLASSIFIED DRUG; IMMUNOGLOBULIN FRAGMENT; SDC1 PROTEIN, HUMAN; VIRUS HEMAGGLUTININ;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG TARGETING; GENETIC ENGINEERING; HUMAN; HUMAN CELL; HUMAN TISSUE; MEASLES; MULTIPLE MYELOMA; MYELOMA CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BONE MARROW CELL; CERCOPITHECUS; CHEMISTRY; CYTOLOGY; GENETICS; MEASLES VIRUS; METABOLISM; METHODOLOGY; PATHOGENICITY; PLASMA CELL; TUMOR CELL CULTURE; VERO CELL; VIROLOGY;

MEASLES VIRUS;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; BONE MARROW CELLS; CERCOPITHECUS AETHIOPS; GENETIC ENGINEERING; HEMAGGLUTININS, VIRAL; HUMANS; IMMUNOGLOBULIN FRAGMENTS; MEASLES VIRUS; MULTIPLE MYELOMA; PLASMA CELLS; SYNDECAN-1; TUMOR CELLS, CULTURED; VERO CELLS;

EID: 63449087333     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.007302-0     Document Type: Article

References (24)

1. Cattaneo, R., Miest, T., Shashkova, E. V. & Barry, M. A. (2008). Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded. Nat Rev Microbiol 6, 529-540.
2. Dingli, D., Peng, K.-W., Harvey, M. E., Greipp, P. R., O'Connor, M. K., Cattaneo, R., Morris, J. C. & Russell, S. J. (2004). Image-guided radiovirotherapy for multiple myeloma using a recombinant measles virus expressing the thyroidal sodium iodide symporter. Blood 103, 1641-1646.
3. Dörig, R. E., Marcil, A., Chopra, A. & Richardson, C. D. (1993). The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75, 295-305.
4. Duprex, W. P., McQuaid, S., Hangartner, L., Billeter, M. A. & Rima, B. K. (1999). Observation of measles virus cell-to-cell spread in astrocytoma cells by using a green fluorescent protein-expressing recombinant virus. J Virol 73, 9568-9575.
5. ller-Hermelink, H. K. (2000a). Characterization of Wue-1, a novel monoclonal antibody that stimulates the growth of plasmacytoma cell lines. Virchows Arch 437, 372-379.
6. Greiner, A., Muller, K. B., Hess, J., Pfeffer, K., Müller-Hermelink, H. K. & Wirth, T. (2000b). Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas. Am J Pathol 156, 501-507.
7. Grote, D., Russell, S. J., Cornu, T. I., Cattaneo, R., Vile, R., Poland, G. A. & Fielding, A. K. (2001). Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice. Blood 97, 3746-3754.
8. Harris, N. L., Jaffe, E. S., Diebold, J., Flandrin, G., Muller-Hermelink, H. K., Vardiman, J., Lister, T. A. & Bloomfield, C. D. (2000). The World Health Organization classification of hematological malignancies report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997. Mod Pathol 13, 193-207.
9. Harrison, S. J. & Cook, G. (2005). Immunotherapy in multiple myeloma - possibility or probability? Br J Haematol 130, 344-362.
10. Iankov, I. D., Blechacz, B., Liu, C., Schmeckpeper, J. D., Tarara, J. E., Federspiel, M. J., Caplice, N. & Russell, S. J. (2007). Infected cell carriers: a new strategy for systemic delivery of oncolytic measles viruses in cancer virotherapy. Mol Ther 15, 114-122.
11. Kärber, G. (1931). Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Naunyn-Schmiedebergs Arch Pharmakol 162, 480-483 (in German).
12. Kondo, E., Topp, M. S., Kiem, H. P., Obata, Y., Morishima, Y., Kuzushima, K., Tanimoto, M., Harada, M., Takahashi, T. & Akatsuka, Y. (2002). Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells. J Immunol 169, 2164-2171.
13. Leonard, V. H. J., Sinn, P. L., Hodge, G., Miest, T., Deveaux, P., Oezguen, N., Braun, W., McCray, P. B., Jr, McChesney, M. B. & Cattaneo, R. (2008). Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. J Clin Invest 118, 2448-2458.
14. Nakamura, T. & Russell, S. J. (2004). Oncolytic measles viruses for cancer therapy. Expert Opin Biol Ther 4, 1685-1692.
15. Nakamura, T., Peng, K. W., Harvey, M., Greiner, S., Lorimer, I. A., James, C. D. & Russell, S. J. (2005). Rescue and propagation of fully retargeted oncolytic measles viruses. Nat Biotechnol 23, 209-214.
16. Naniche, D., Varior-Krishnan, G., Cervoni, F., Wild, T. F., Rossi, B., Rabourdin-Combe, C. & Gerlier, D. (1993). Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J Virol 67, 6025-6032.
17. Ong, H. T., Hasegawa, K., Dietz, A. B., Russell, S. J. & Peng, K.-W. (2007). Evaluation of T cells as carriers for systemic measles virotherapy in the presence of antiviral antibodies. Gene Ther 14, 324-333.
18. Parato, K. A., Senger, D., Forsyth, P. A. J. & Bell, J. C. (2005). Recent progress in the battle between oncolytic viruses and tumours. Nat Rev Cancer 5, 965-976.
19. Radecke, F., Spielhofer, P., Schneider, H., Kaelin, K., Huber, M., Dötsch, C., Christiansen, G. & Billeter, M. A. (1995). Rescue of measles viruses from cloned DNA. EMBO J 14, 5773-5784.
20. Spearman, C. (1908). The method of right and wrong cases (constant stimuli) without Gauss's formulae. Br J Psychol 2, 227-242.
21. Tatsuo, H., Ono, N., Tanaka, K. & Yanagi, Y. (2000). SLAM (CDw150) is a cellular receptor for measles virus. Nature 406, 893-897.
22. Treon, S. P., Raje, N. & Anderson, K. C. (2000). Immunotherapeutic strategies for the treatment of plasma cell malignancies. Semin Oncol 27, 598-613.
23. Yanagi, Y., Takeda, M. & Ohno, S. (2006). Measles virus: cellular receptors, tropism and pathogenesis. J Gen Virol 87, 2767-2779.
24. Zuniga, A., Wang, Z., Liniger, M., Hangartner, L., Caballero, M., Pavlovic, J., Wild, P., Viret, J. F., Glueck, R. & other authors (2007). Attenuated measles virus as a vaccine vector. Vaccine 25, 2974-2983.