Association of the PIK4CA Schizophrenia-Susceptibility Gene in Adults with the 22q11.2 Deletion Syndrome

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 150, Issue 3, 2009, Pages 430-433

  Vorstman, Jacob A S ^a,f   Chow, Eva W ^b,c   Ophoff, Roel A ^a,d,e   Van Engeland, Herman ^a   Beemer, Frits A ^d   Kahn, René S ^a   Sinke, Richard J ^d   Bassett, Anne S ^b,c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f NONE   (Netherlands)

Author keywords

Chromosome 22q11.2 deletion syndrome; PIK4CA; Schizophrenia; Susceptibility gene

Indexed keywords

PHOSPHATIDYLINOSITOL KINASE; PHOSPHATIDYLINOSITOL KINASE CATALYTIC ALPHA; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CHROMOSOME 22Q; CHROMOSOME DELETION; CHROMOSOME DELETION 22Q; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 63449086286     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30827     Document Type: Article

References (11)

1. Barrett JC, Fry B, Mailer J, Daly MJ. 2005. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
2. Bassett AS, Chow EW. 2008. Schizophrenia 22q11.2 deletion syndrome. Curr Psychiatry Rep 10:148-157.
3. Bassett AS, Chow EW, O'Neill S, Brzustowicz LM. 2001. Genetic insights into the neurodevelopmental hypothesis of schizophrenia. Schizophr Bull 27:417-430.
4. Bassett AS, Caluseriu O, Weksberg R, Young DA, Chow EW. 2007. Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome. Biol Psychiatry 61:1135-1140.
5. Hoogendoorn ML, Vorstman JA, Jalali GR, Selten JP, Sinke RJ, Emanuel BS, KahnRS. 2008. Prevalenceof22q11.2 deletions in311 Dutchpatients with schizophrenia. Schizophr Res 98:84-88.
6. Jalali GR, Vorstman JA, Errami A, Vijzelaar R, Biegel J, Shaikh T, Emanuel BS. 2008. Detailed analysis of 22q11.2 with a high density MLPA probe set. Hum Mutat 29:433-440.
7. Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't SR, Bardoel AF, Ophoff RA, Wijmenga C, Kahn RS, Sinke RJ. 2007. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. Mol Psychiatry Sept 25. [Epub ahead of print].
8. Nakagawa T, Goto K, Kondo H. 1996. Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase. J Biol Chem 271:12088-12094.
9. Saito T, Guan F, Papolos DF, Rajouria N, Fann CS, Lachman HM. 2001. Polymorphism in SNAP29 gene promoter region associated with schizophrenia. Mol Psychiatry 6:193-201.
10. Shaikh TH, Kurahashi H, Saitta SC, O'Hare AM, Hu P, Roe BA, Driscoll DA, McDonald-McGinn DM, Zackai EH, Budarf ML, Emanuel BS. 2000. Chromosome 22-specific low copy repeats and the 22q11.2 deletion syndrome: Genomic organization and deletion endpoint analysis. Hum Mol Genet 9:489-501.
11. Wonodi I, Hong LE, Avila MT, Buchanan RW, Carpenter WT Jr., Stine OC, Mitchell BD, Thaker GK. 2005. Association between polymorphism of the SNAP29 gene promoter region and schizophrenia. Schizophr Res 78:339-341.