Simulation and experimental verification of micro polymerase chain reaction chips

2000 International Conference on Modeling and Simulation of Microsystems - MSM 2000

Volumn , Issue , 2000, Pages 648-651

  Lin, Yu Cheng ^a   Yang, Chung Che ^a   Hwang, Ming Yuan ^a   Chang, Yao Te ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

DNA; FEA; PCR

Indexed keywords

COMPUTER SIMULATION; DNA; FINITE ELEMENT METHOD; HEATING; SILICON; TEMPERATURE DISTRIBUTION; THERMAL CONDUCTIVITY; THERMAL CYCLING;

CHAIN REACTION; HEATING SURFACES; MICRO POLYMERASE; POLYMERASE CHAIN REACTION (PCR); REACTION CHAMBERS;

ENZYMES;

EID: 6344290158     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (7)

1. A. Manz, D.J. Harrison, E.M.J. Verpoorte, J.C. Fettinger, A. Paulus, H. Ludi and H.M. Widmer, "Planar chips technology for miniaturization and integration of separation techniques into monitoring systems", J. Chromatogr., 593, pp. 253-258. 1992.
2. M.A. Northrup, M.T. Ching, R.M. White, and R.T. Watson, "DNA Amplification in a Microfabricated Reaction Chamber," In Transducers '93. Seventh International Conference on Solid State Sensors and Actuators, Yokohama, Japan, June 1993, pp. 924-926.
3. th international Conference on Solid-State Sensors and Actuators, and Eurosensors IX, Stockholm, Sweden, June 1995, pp.764-767.
4. J. Cheng, M.A. Shoffner, G.E. Hvichia, L.J. Kricka and P. Wilding, "Chip PCR. II. Investigation of different PCR amplification systems in microfabricated silicon-glass chips, "Nucleic Acids Research, 24, pp. 380-385, 1996.
5. S. Poser, T. Schulz, U. Dillner, V. Baier, J. M. Kohler, D. Schirnkat, G. Mayer, A. Siebert, "Chip element for fast thermocycling", Sensors and Actuators A, A62, pp. 672-675, 1997.
6. A.M. Chaudhari, T. Woudenberg, M. Albin, and K.E. Gooson, "Transient Liquid Crystal Thermometry of Microfabricated PCR Vessel Arrays", Journal of Microelectromechanical Systems, Vol. 7, No 4, pp. 345-355, 1998.
7. M. Deshpande, K.B. Greiner, B.F. Romanowicz, J.R. Gilbert, P.M. St. John, T. Woudenberg, "CAD Analysis of PCR Well Containment", MSM1999, San Juan, Puerto Rico, USA, April 1999.