UVB radiation-mediated expression of inducible nitric oxide synthase activity and the augmenting role of co-induced TNF-α in human skin endothelial cells

Journal of Investigative Dermatology

Volumn 123, Issue 5, 2004, Pages 950-957

  Suschek, Christoph Viktor ^a   Mahotka, Csaba ^a   Schnorr, Oliver ^a   Kolb Bachofen, Victoria ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Cationic amino acid transporter; Cytokines; Endothelial cells; Inducible nitric oxide synthase; Nitric oxide; TNF ; UVB

Indexed keywords

AMINO ACID TRANSPORTER; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CULTURED HUMAN DERMAL CELL; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SKIN CELL; SKIN INFLAMMATION; TIME; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; VASCULAR ENDOTHELIUM;

EID: 6344275004     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23422.x     Document Type: Article

References (38)

1. Bazzoni F, Kruys V, Shakhov A, Jongeneel CV, Beutler B: Analysis of tumor necrosis factor promoter responses to ultraviolet light. J Clin Invest 93: 56-62, 1994
2. Black HS: Potential involvement of free radical reactions in ultraviolet light-mediated cutaneous damage. Photochem Photobiol 46:213-221, 1987
3. Bruch-Gerharz D, Fehsel K, Suschek C, Michel G, Ruzicka T, Kolb-Bachofen V: A proinflammatory activity of interleukin-8 in human skin: Expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes. J Exp Med 184:2007-2012, 1996
4. Bruls WA, Slaper H, van der Leun JC, Berrens L: Transmission of human epidermis and stratum corneum as a function of thickness in the ultraviolet and visible wavelengths. Photochem Photobiol 40:485-494, 1984a
5. Bruls WA, van Weelden H, van der Leun JC: Transmission of UV-radiation through human epidermal layers as a factor influencing the minimal erythema dose. Photochem Photobiol 39:63-67, 1984b
6. Closs EI: Expression, regulation and function of carrier proteins for cationic amino acids. Curr Opin Nephrol Hypertens 11:99-107, 2002
7. Closs EI, Scheld JS, Sharafi M, Forstermann U: Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: Role of cationic amino acid transporters. Mol Pharmacol 57:68-74, 2000
8. Corbett JA, Sweetland MA, Wang JL, Lancaster JR Jr, McDaniel ML: Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci USA 90:1731-1735, 1993
9. Danpure HJ, Tyrrell RM: Oxygen dependence of near-UV (365 nm) lethality and the interaction of near-UV and X-rays in two mammalian cell lines. Photochem Photobiol 23:171-177, 1976
10. de Kossodo S, Cruz PD Jr, Dougherty I, Thompson P, Silva-Valdez M, Beutler B: Expression of the tumor necrosis factor gene by dermal fibroblasts in response to ultraviolet irradiation or lipopolysaccharide. J Invest Dermatol 104:318-322, 1995
11. Deliconstantinos G, Villiotu V, Stravides JC: Release by ultraviolet B (u.v.B.) radiation of nitric oxide (NO) from human keratinocytes: A potential role for nitric oxide in erythema production. Br J Pharmacol 114:1257-1265, 1995
12. Gange RW: Acute effects of ultraviolet radiation in the skin. In: Fitzpatrick TB, Eisen AZ, Wolff K, et al: (eds). Dermatology in General Medicine. New York: McGraw-Hill, 1987; p 1451-1457
13. Goldsmith PC, Leslie TA, Hayes NA, Levell NJ, Dowd PA, Foreman JC: Inhibitors of nitric oxide synthase in human skin. J Invest Dermatol 106:113-118, 1996
14. Greaves MW: Ultraviolet erythema: Causes and consequences. Curr Probl Dermatol 15:18-24, 1986
15. Hoffmann G, Schobersberger W, Rieder J, et al: Human dermal microvascular endothelial cells express inducible nitric oxide synthase in vitro. J Invest Dermatol 112:387-390, 1999
16. Holt PG, Oliver J, Bilyk N, McMenamin C, McMenamin PG, Kraal G, Thepen T: Downregulation of the antigen presenting cell functions of pulmonary dendritic cells in vivo by resident peritoneal macrophages. J Exp Med 177:397-407, 1993
17. Jagger J: Solar-UV Action on Living Cells. New York Praeger, 1985
18. Kilbourn RG, Belloni P: Endothelial cell production of nitrogen oxides in response to interferon-gamma, with tumor necrosis factor, interleukin-I, or endotoxin. J Natl Cancer Inst 82:772-776, 1990
19. Köck A, Schwarz T, Kirnbauer R, Urbanski A, Perry P, Ansel JC, Luger TA: Human keratinocytes are a source of tumor necrosis factor alpha: Evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 172:1609-1614, 1990
20. Kolb H, Kolb-Bachofen V: Type 1 (insulin-dependent) diabetes mellitus and nitric oxide. Diabetologia 35:796-797, 1992
21. Langrehr JM, Hoffman RA, Lancester RR Jr, Simmons RL: Nitric oxide. A new endogenous immunomodulator. Transplantation 55:1205-1212, 1993
22. Liew FY, Cox FEG: Nonspecific defense mechanism: The role of nitric oxide. Immunol Today 12:A17-A21, 1991
23. Marzinzig M, Nussler AK, Stadler J, et al: Improved methods to measure end products of nitric oxide in biological fluids: Nitrite, nitrate, and S-nitrosothiols. Nitric Oxide 1:177-189, 1997
24. Matthews SJ, McCoy C: Thalidomide: A review of approved and investigational uses. Clin Ther 25:342-395, 2003
25. Meunier L: Ultraviolet light and dendritic cells. Eur J Dermatol 9:269-275, 1999
26. Mills CD: Molecular basis of "suppressor" macrophages: Arginine metabolism via the nitric oxide synthase pathway. J Immunol 146:2719-2723, 1991
27. Pober JS, Cotran RS: Cytokines and endothelial cell biology. Physiol Rev 70: 427-451, 1990
28. Sastry PS: Inhibition of TNF-alpha synthesis with thalidomide for prevention of acute exacerbations and altering the natural history of multiple sclerosis. Med Hypotheses 53:76-77, 1999
29. Schnorr O, Suschek CV, Kolb-Bachofen V: The importance of cationic amino acid transporter expression in human skin. J Invest Dermatol 120:1016-1022, 2003
30. Strickland I, Rhodes LE, Flanagan BF, Friedmann PS: TNF-alpha and IL-8 are upregulated in the epidermis of normal human skin after UVB exposure: Correlation with neutrophil accumulation and E-selectin expression. J Invest Dermatol 108:763-768, 1997
31. Suschek C, Fehsel K, Kröncke K-D, Sommer A, Kolb-Bachofen V: Primary cultures of rat capillary endothelial cells: Constitutive and cytokine-inducible macrophage-like nitric oxide syntheses are expressed and activities regulated by glucose concentration. Am J Pathol 145:485-695, 1994
32. Suschek C, Rothe H, Fehsel K, Enczmann J, Kolb-Bachofen V: Induction of a macrophage-like nitric oxide synthase in cultured rat aortic endothelial cells. J Immunol 151:3283-3291, 1993
33. Suschek CV, Briviba K, Bruch-Gerharz D, Sies H, Kröncke KD, Kolb-Bachofen V: Even after UVA-exposure will nitric oxide protect cells from reactive oxygen intermediate-mediated apoptosis and necrosis. Cell Death Differ 8:515-527, 2001a
34. Suschek CV, Bruch-Gerharz D, Kleinert H, Förstermann U, Kolb-Bachofen V: Ultraviolet A1 radiation induces nitric oxide synthase-2 expression in human skin endothelial cells in the absence of proinflammatory cytokines. J Invest Dermatol 117:1200-1205, 2001b
35. Suschek CV, Krischel V, Bruch-Gerharz D, Berendji D, Krutmann J, Kröncke K-D, Kolb-Bachofen V: Nitric oxide fully protects against UVA-induced apoptosis in tight correlation with Bcl-2 up-regulation. J Biol Chem 274:6130-6137, 1999
36. Suschek CV, Schnorr O, Hemmrich K, Aust O, Klotz LO, Sies H, Kolb-Bachofen V: Critical role of L-arginine in endothelial cell survival during oxidative stress. Circulation 107:2607-2614, 2003
37. Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB: Nitric oxide (NO) protects against cellular damage by reactive oxygen species. Toxicol Lett 82/83:221-226, 1995
38. Wink DA, Hanbauer I, Grisham MB, et al: Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms. Curr Top Cell Reg 34: 159-187, 1996