Associations of serum EBV DNA and gammopathy with post-transplant lymphoproliferative disease

Clinical Transplantation

Volumn 23, Issue 1, 2009, Pages 74-82

  Rosselet, Anne ^a   Vu, Dinh Hao ^b   Meylan, Pascal ^a   Baur Chaubert, Audrey S ^a   Schapira, Marc ^a   Pascual, Manuel ^a   Aubert, Vincent ^a   Tissot, Jean Daniel ^b   Duchosal, Michel A ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b Service Regional Vaudois de Transfusion Sanguine   (Switzerland)

Author keywords

Barr virus; Capillary zone electrophoresis; Epstein; Gammopathy; Posttransplant lymphoproliferative disease; Two dimensional gel electrophoresis

Indexed keywords

ANTIVIRUS AGENT; CD20 ANTIBODY; VIRUS DNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EPSTEIN BARR VIRUS; FEMALE; GAMMOPATHY; HUMAN; HUMAN TISSUE; LYMPHOPROLIFERATIVE DISEASE; MALE; NONHUMAN; POSTTRANSPLANTATION LYMPHOPROLIFERATIVE DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TWO DIMENSIONAL GEL ELECTROPHORESIS; VIRUS LOAD;

ADOLESCENT; ADULT; AGED; DNA, VIRAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOSUPPRESSIVE AGENTS; IN SITU HYBRIDIZATION; INCIDENCE; KIDNEY TRANSPLANTATION; LYMPHOPROLIFERATIVE DISORDERS; MALE; MIDDLE AGED; PARAPROTEINEMIAS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TRANSPLANTATION, HOMOLOGOUS; VIRAL LOAD; YOUNG ADULT;

EID: 63349107757     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2008.00904.x     Document Type: Article

References (48)

1. Cohen JI. Epstein-Barr virus infection. N Engl J Med 2000: 343: 481.
2. Domingo-Domenech E, de Sanjose S, Gonzalez-Barca E et al. Post-transplant lymphomas: A 20-year epidemiologic, clinical and pathologic study in a single center. Haematologica 2001: 86: 715.
3. Loren AW, Porter DL, Stadtmauer EA, Tsai DE. Post-transplant lymphoproliferative disorder: A review. Bone Marrow Transplant 2003: 31: 145.
4. Harris NL, Ferry JA, Swerdlow SH. Posttransplant lymphoproliferative disorders: Summary of Society for Hematopathology Workshop. Semin Diagn Pathol 1997: 14: 8.
5. Chadburn A, Chen JM, Hsu DT et al. The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders are clinically relevant. Cancer 1998: 82: 1978.
6. Rowe DT, Webber S, Schauer EM, Reyes J, Green M. Epstein-Barr virus load monitoring: Its role in the prevention and management of post-transplant lymphoproliferative disease. Transplant Infect Dis 2001: 3: 79.
7. Allen U, Hebert D, Petric M et al. Utility of semiquantitative polymerase chain reaction for Epstein-Barr virus to measure virus load in pediatric organ transplant recipients with and without posttransplant lymphoproliferative disease. Clin Infect Dis 2001: 33: 145.
8. Baldanti F, Grossi P, Furione M et al. High levels of Epstein-Barr virus DNA in blood of solid-organ transplant recipients and their value in predicting posttransplant lymphoproliferative disorders. J Clin Microbiol 2000: 38: 613.
9. Stevens SJ, Vervoort MB, van den Brule AJ et al. Monitoring of epstein-barr virus DNA load in peripheral blood by quantitative competitive PCR. J Clin Microbiol 1999: 37: 2852.
10. Orii T, Ohkohchi N, Kikuchi H et al. Usefulness of quantitative real-time polymerase chain reaction in following up patients with Epstein-Barr virus infection after liver transplantation. Clin Transplant 2000: 14: 308.
11. Matsukura T, Yokoi A, Egawa H et al. Significance of serial real-time PCR monitoring of EBV genome load in living donor liver transplantation. Clin Transplant 2002: 16: 107.
12. Tsai DE, Aqui NA, Tomaszewski JE et al. Serum protein electrophoresis abnormalities in adult solid organ transplant patients with post-transplant lymphoproliferative disorder. Clin Transplant 2005: 19: 644.
13. Lemoine A, Pham P, Azoulay D et al. Detection of gammopathy by serum protein electrophoresis for predicting and managing therapy of lymphoproliferative disorder in 911 recipients of liver transplants. Blood 2001: 98: 1332.
14. Kent EF Jr, Crawford J, Cohen HJ, Buckley RH. Development of multiple monoclonal serum immunoglobulins (multiclonal gammopathy) folowing both HLA-identical unfractionated and T cell-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency. J Clin Immunol 1990: 10: 106.
15. Niesters HG, van Esser J, Fries E et al. Development of a real-time quantitative assay for detection of Epstein-Barr virus. J Clin Microbiol 2000: 38: 712.
16. Cockfield SM. Identifying the patient at risk for post-transplant lymphoproliferative disorder. Transplant Infect Dis 2001: 3: 70.
17. Vallet V, Mauray S, Kindler V et al. Human tonsil implants xenotransplanted in SCID mice display broad lymphocytic diversity and cellular activation profile similar to those in the original lymphoid organ. Xenotransplantation 2005: 12: 38.
18. Kunzle N, Petignat C, Francioli P et al. Preemptive treatment approach to cytomegalovirus (CMV) infection in solid organ transplant patients: relationship between compliance with the guidelines and prevention of CMV morbidity. Transplant Infect Dis 2000: 2: 118.
19. Chatellard P, Sahli R, Iten A, von OJ, Meylan PR. Single tube competitive PCR for quantitation of CMV DNA in the blood of HIV+ and solid organ transplant patients. J Virol Methods 1998: 71: 137.
20. Kimura H, Morita M, Yabuta Y et al. Quantitative analysis of Epstein-Barr virus load by using a real-time PCR assay. J Clin Microbiol 1999: 37: 132.
21. Harari A, Vallelian F, Meylan PR, Pantaleo G. Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J Immunol 2005: 174: 1037.
22. Tissot J-D, Schneider P, Hohlfeld P et al. Two-dimensional electrophoresis as an aid in the analysis of the clonality of immunoglobulins. Electrophoresis 1993: 14: 1366.
23. Tissot J-D, Schneider P, Duchosal MA. Two-dimensional polyacrylamide gel electrophoresis. In: W ilson ID, A dlar ER, C ook M, P oole CF, eds. Encyclopedia of Separation Science. Vol 3. London: Academic Press, 2000: 1364.
24. Vuadens F, Crettaz D, Scelatta C et al. Plasticity of protein expression during culture of fetal skin cells. Electrophoresis 2003: 24: 1281.
25. Vuadens F, Benay C, Crettaz D et al. Identification of biologic markers of the premature rupture of fetal membranes: Proteomic approach. Proteomics 2003: 3: 1521.
26. Berger C, Day P, Meier G et al. Dynamics of Epstein-Barr virus DNA levels in serum during EBV-associated disease. J Med Virol 2001: 64: 505.
27. Limaye AP, Huang ML, Atienza EE, Ferrenberg JM, Corey L. Detection of Epstein-Barr virus DNA in sera from transplant recipients with lymphoproliferative disorders. J Clin Microbiol 1999: 37: 1113.
28. Lei KI, Chan LY, Chan WY, Johnson PJ, Lo YM. Quantitative analysis of circulating cell-free Epstein-Barr virus (EBV) DNA levels in patients with EBV-associated lymphoid malignancies. Br J Haematol 2000: 111: 239.
29. Wagner H-J, Wessel M, Jabs W et al. Patients at risk for development of posttransplant lymphoproliferative disorder: Plasma versus peripheral blood mononuclear cells as material for quantification of Epstein-Barr viral load by using real-time quantitative polymerase chain reaction. Transplantation 2001: 72: 1012.
30. Stevens SJ, Pronk I, Middeldorp JM. Toward standardization of Epstein-Barr virus DNA load monitoring: Unfractionated whole blood as preferred clinical specimen. J Clin Microbiol 2001: 39: 1211.
31. Rose C, Green M, Webber S et al. Pediatric solid-organ transplant recipients carry chronic loads of Epstein-Barr virus exclusively in the immunoglobulin D-negative B-cell compartment. J Clin Microbiol 2001: 39: 1407.
32. Muti G, Cantoni S, Oreste P et al. Post-transplant lymphoproliferative disorders: Improved outcome after clinico-pathologically tailored treatment. Haematologica 2002: 87: 67.
33. Badley AD, Portela DF, Patel R et al. Development of monoclonal gammopathy precedes the development of Epstein-Barr virus-induced posttransplant lymphoproliferative disorder. Liver Transplant Surg 1996: 2: 375.
34. Pham H, Lemoine A, Sol O et al. Monoclonal and oligoclonal gammopathies in liver transplant recipients. Transplantation 1994: 58: 253.
35. Pageaux GP, Bonnardet A, Picot MC et al. Prevalence of monoclonal immunoglobulins after liver transplantation: Relationship with posttransplant lymphoproliferative disorders. Transplantation 1998: 65: 397.
36. Pham H, Lemoine A, Salvucci M et al. Occurrence of gammopathies and lymphoproliferative disorders in liver transplant recipients randomized to tacrolimus (FK506)- or cyclosporine-based immunosuppression. Liver Transplant Surg 1998: 4: 146.
37. Peest D, Schaper B, Nashan B et al. High incidence of monoclonal immunoglobulins in patients after liver or heart transplantation. Transplantation 1988: 46: 389.
38. Chakalarovski C, Lang P, Buisson C et al. Monoclonal immunoglobulins in patients with renal transplants: Characterization, evolution and risk factors. Transplant Int 1992: 5 (Suppl.): S23.
39. Bernardi M, La Rocca E, Castoldi R et al. Mono-oligoclonal immunoglobulin abnormalities in diabetic patients after kidney transplantation: Influence of simultaneous pancreas graft. Diabetologia 1998: 41: 1176.
40. Litwin CM, Anderson SK, Philipps G et al. Comparison of capillary zone and immunosubtraction with agarose gel and immunofixation electrophoresis for detecting and identifying monoclonal gammopathies. Am J Clin Pathol 1999: 112: 411.
41. Fischer AM, Simon F, Le Deist F et al. Prospective study of the occurrence of monoclonal gammapathies following bone marrow transplantation in young children. Transplantation 1990: 49: 731.
42. Rinaldi A, Kwee I, Poretti G et al. Comparative genome-wide profiling of post-transplant lymphoproliferative disorders and diffuse large B-cell lymphomas. Br J Haematol 2006: 134: 27.
43. Dossetor JB, Kovithavongs T, Salkie M, Preiksaitis J. Cyclosporine-associated lymphoproliferation, despite controlled cyclosporine blood concentrations, in a renal allograft recipient. Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985: 21: 1021.
44. Touchard G, Pasdeloup T, Parpeix J et al. High prevalence and usual persistence of serum monoclonal immunoglobulins evidenced by sensitive methods in renal transplant recipients. Nephrol Dial Transplant 1997: 12: 1199.
45. Drouet E, Chapuis -Cellier C, Bosshard S et al. Oligo-monoclonal immunoglobulins frequently develop during concurrent cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections in patients after renal transplantation. Clin Exp Immunol 1999: 118: 465.
46. Vodopick H, Chaskes SJ, Solomon A, Stewart JA. Transient monoclonal gammopathy associated with cytomegalovirus infection. Blood 1974: 44: 189.
47. Hutt -Fletcher LM, Balachandran N, Elkins MH. B cell activation by cytomegalovirus. J Exp Med 1983: 158: 2171.
48. Carney WP, Iacoviello V, Hirsch MS. Functional properties of T lymphocytes and their subsets in cytomegalovirus mononucleosis. J Immunol 1983: 130: 390.