Connexin32 is expressed in vascular endothelial cells and participates in gap-junction intercellular communication

Biochemical and Biophysical Research Communications

Volumn 382, Issue 2, 2009, Pages 264-268

  Okamoto, Takayuki ^a   Akiyama, Mari ^a   Takeda, Mariko ^a   Gabazza, Esteban C ^a   Hayashi, Tatsuya ^a   Suzuki, Koji ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Blood coagulation; Cell cell interaction; Connexin32; Cx32 knock out mice; Endothelial cells; Endothelial functions; Gap junctions; Vascular inflammation

Indexed keywords

CONNEXIN 32; DYE; MESSENGER RNA; MONOCLONAL ANTIBODY;

ARTICLE; BLOOD VESSEL; CELL COMMUNICATION; CELL CULTURE; CELL JUNCTION; CONTROLLED STUDY; ENDOTHELIUM CELL; GAP JUNCTION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM; WILD TYPE;

ANIMALS; CELL COMMUNICATION; CELLS, CULTURED; CONNEXINS; ENDOTHELIUM, VASCULAR; GAP JUNCTIONS; HUMANS; MICE;

MUS;

EID: 63349107500     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.02.148     Document Type: Article

References (34)

1. Pearson J.D. Endothelial cell function and thrombosis. Baillieres Best Pract. Res. Clin. Haematol. 12 3 (1999) 329-341
2. Michiels C. Endothelial cell functions. J. Cell. Physiol. 196 3 (2003) 430-443
3. Steffens S., and Mach F. Inflammation and atherosclerosis. Herz 29 8 (2004) 741-748
4. Blanco M., Rodriguez-Yanez M., Sobrino T., Leira R., and Castillo J. Platelets, inflammation, and atherothrombotic neurovascular disease: the role of endothelial dysfunction. Cerebrovasc. Dis. 20 Suppl. 2 (2005) 32-39
5. Steffel J., Luscher T.F., and Tanner F.C. Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications. Circulation 113 5 (2006) 722-731
6. Kumar N.M., and Gilula N.B. The gap junction communication channel. Cell 84 3 (1996) 381-388
7. Saez J.C., Berthoud V.M., Branes M.C., Martinez A.D., and Beyer E.C. Plasma membrane channels formed by connexins: their regulation and functions. Physiol. Rev. 83 4 (2003) 1359-1400
8. Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., et al. Structural and functional diversity of connexin genes in the mouse and human genome. Biol. Chem. 383 5 (2002) 725-737
9. Sohl G., and Willecke K. Gap junctions and the connexin protein family. Cardiovasc. Res. 62 2 (2004) 228-232
10. Oyamada M., Oyamada Y., and Takamatsu T. Regulation of connexin expression. Biochim. Biophys. Acta 1719 1-2 (2005) 6-23
11. Hill C.E., Rummery N., Hickey H., and Sandow S.L. Heterogeneity in the distribution of vascular gap junctions and connexins: implications for function. Clin. Exp. Pharmacol. Physiol. 29 7 (2002) 620-625
12. van Rijen H.V., van Kempen M.J., Postma S., and Jongsma H.J. Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells. Cytokine 10 4 (1998) 258-264
13. Wong C.W., Burger F., Pelli G., Mach F., and Kwak B.R. Dual benefit of reduced Cx43 on atherosclerosis in LDL receptor-deficient mice. Cell Commun. Adhes. 10 4-6 (2003) 395-400
14. Wong C.W., Christen T., Roth I., Chadjichristos C.E., Derouette J.P., Foglia B.F., et al. Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nat. Med. 12 8 (2006) 950-954
15. Kostin S., Rieger M., Dammer S., Hein S., Richter M., Klovekorn W.P., et al. Gap junction remodeling and altered connexin43 expression in the failing human heart. Mol. Cell. Biochem. 242 1-2 (2003) 135-144
16. Yamada Y., Izawa H., Ichihara S., Takatsu F., Ishihara H., Hirayama H., et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N. Engl. J. Med. 347 24 (2002) 1916-1923
17. Haefliger J.A., Krattinger N., Martin D., Pedrazzini T., Capponi A., Doring B., et al. Connexin43-dependent mechanism modulates renin secretion and hypertension. J. Clin. Invest. 116 2 (2006) 405-413
18. Spray D.C., Bai S., Burk R.D., and Saez J.C. Regulation and function of liver gap junctions and their genes. Prog. Liver Dis. 12 (1994) 1-18
19. Zhang J.T., and Nicholson B.J. Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA. J. Cell Biol. 109 6 Pt. 2 (1989) 3391-3401
20. Lee M.J., Nelson I., Houlden H., Sweeney M.G., Hilton-Jones D., Blake J., et al. Six novel connexin32 (GJB1) mutations in X-linked Charcot-Marie-Tooth disease. J. Neurol. Neurosurg. Psychiatry 73 3 (2002) 304-306
21. Goodenough D.A., and Paul D.L. Beyond the gap: functions of unpaired connexon channels. Nat. Rev. 4 4 (2003) 285-294
22. Yang J., Ichikawa A., and Tsuchiya T. A novel function of connexin 32: marked enhancement of liver function in a hepatoma cell line. Biochem. Biophys. Res. Commun. 307 1 (2003) 80-85
23. Luebeck E.G., Buchmann A., Schneider D., Moolgavkar S.H., and Schwarz M. Modulation of liver tumorigenesis in Connexin32-deficient mouse. Mutat. Res. 570 1 (2005) 33-47
24. Yamamoto T., Kojima T., Murata M., Takano K., Go M., Hatakeyama N., et al. p38 MAP-kinase regulates function of gap and tight junctions during regeneration of rat hepatocytes. J. Hepatol. 42 5 (2005) 707-718
25. Hirabayashi Y., Yoon B.I., Tsuboi I., Huo Y., Kodama Y., Kanno J., et al. Membrane channel connexin 32 maintains Lin(-)/c-kit(+) hematopoietic progenitor cell compartment: analysis of the cell cycle. J. Membr. Biol. 217 1-3 (2007) 105-113
26. Paul D.L. Molecular cloning of cDNA for rat liver gap junction protein. J. Cell. Biol. 103 1 (1986) 123-134
27. Manjunath C.K., Goings G.E., and Page E. Human cardiac gap junctions: isolation, ultrastructure, and protein composition. J. Mol. Cell. Cardiol. 19 2 (1987) 131-134
28. Brouland J.P., Gilbert M.A., Bonneau M., Pignaud G., Bal Dit Solier C., and Drouet L. Macro and microheterogeneity in normal endothelial cells: differential composition of luminal glycocalyx and functional implications. Endothelium 6 3 (1999) 251-262
29. Mitra S., Annamalai L., Chakraborty S., Johnson K., Song X.H., Batra S.K., et al. Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. Mol. Biol. Cell 17 12 (2006) 5400-5416
30. Duffy H.S., Iacobas I., Hotchkiss K., Hirst-Jensen B.J., Bosco A., Dandachi N., et al. The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1. J. Biol. Chem. 282 13 (2007) 9789-9796
31. Brisset A.C., Isakson B.E., and Kwak B.R. Connexins in vascular physiology and pathology. Antioxid. Redox Signal. 11 2 (2009) 267-282
32. Kwak B.R., Mulhaupt F., Veillard N., Gros D.B., and Mach F. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 22 2 (2002) 225-230
33. Kwak B.R., Veillard N., Pelli G., Mulhaupt F., James R.W., Chanson M., et al. Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. Circulation 107 7 (2003) 1033-1039
34. Rignault S., Haefliger J.A., Gasser D., Markert M., Nicod P., Liaudet L., et al. Sepsis up-regulates the expression of connexin 40 in rat aortic endothelium. Crit Care Med. 33 6 (2005) 1302-1310