Recommended dosage adaptation based on renal function is not always sufficient to avoid betalactam antibiotics side effects;Les recommandations d'adaptation posologique à la fonction rénale ne sont pas toujours suffisantes pour éviter la neurotoxicité des bêtalactamines

Nephrologie et Therapeutique

Volumn 5, Issue 2, 2009, Pages 144-148

  Lemaire Hurtel, Anne Sophie ^a,b   Gras Champel, Valérie ^a,b   Hary, Lionel ^a   Masmoudi, Kamel ^a   Massy, Ziad ^a,b   Andréjak, Michel ^a,b  

^a AMIENS UNIVERSITY HOSPITAL   (France)

^b INSERM   (France)

Author keywords

Betalactams antibiotics; Neurotoxicity; Renal impairment

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; BETA LACTAM ANTIBIOTIC; CEFEPIME; CEFOTAXIME; CEFTRIAXONE; CILASTATIN PLUS IMIPENEM; CLOXACILLIN; CREATININE; PIPERACILLIN;

ADULT; AGED; AGITATION; ARTICLE; BRAIN DISEASE; CLINICAL ARTICLE; CONFUSION; CONVULSION; CREATININE CLEARANCE; DISORIENTATION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG SURVEILLANCE PROGRAM; EPILEPSY; FEMALE; GRAND MAL EPILEPSY; HALLUCINATION; HUMAN; HYPOTHESIS; KIDNEY FUNCTION; MALE; MYOCLONUS; NEUROTOXICITY; SIDE EFFECT; TONIC CLONIC SEIZURE;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CREATININE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; FEMALE; FRANCE; GABA ANTAGONISTS; HUMANS; KIDNEY DISEASES; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PRACTICE GUIDELINES AS TOPIC; RETROSPECTIVE STUDIES;

EID: 63349107114     PISSN: 17697255     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nephro.2008.10.004     Document Type: Article

References (12)

1. Bergan T. Pharmakokinetics of betalactam antibiotics. Scand J Infect Dis Suppl 42 (1984) 83-98
2. Petri Jr. W.A. Chapter 45. In: Hardman J.G., Limbird L.E., and Gilman A.G. (Eds). Goodman & Gilman's The pharmacological basis of therapeutics (2001), McGraw Hill, NY
3. Grondahl T.O., and Langmoen I.A. Epileptogenic effect of antibiotics drugs. J Neurosurg (1993) 78-938
4. De Sarro A., Ammendola D., Zappala M., et al. Relationship between structure and convulsant properties of some betalactam antibiotics following intracerebroventricular microinjection in rats. Antimicrob Agents Chemother (1995) 39-232
5. Macdonald R.L., and Barker J.L. Pentylenetetrazole and penicillin are selective agonists of GABA-mediated post synaptic inhibition in cultured mammalian neurons. Nature (1977) 267-720
6. Chow P., and Mathers D. Convulsant doses of penicillin shorten the lifetime of GABA-induced channels in cultured central neurons. Br J Pharmacol (1986) 88-541
7. Rivera M., Crespo M., Teruel J.L., Marcén R., and Ortuño J. Neurotoxicity due to imipenem/cilastatin in patients on continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant 14 (1999) 258-259
8. Mandell G.L., and Petri Jr. W.A. Antimicrobial agents (cont.) penicillins, cephalosporins, and other betalactam antibiotics, Chapter 45. In: Hardman J.G., and Lee E. (Eds). Godman & Gilman's The pharmacological basis of therapeutics. 9th ed. (1996), Limbird, McGraw Hill, New York 1073-1101
9. Schwartz M.T., and Calvert J.F. Potential neurologic toxicity related to ciprofloxacin. DICP 24 (1990) 138-140
10. Bennett W.M., et al. Drug prescribing in renal failure: dosing guidelines for adults. Am J Kidney Dis 3 (1983) 155-193
11. Service ICAR, service de néphrologie de l'hôpital Pitié-Salpêtrière http://www.soc-nephrologie.org/ICAR/index.htm.
12. e Édition. Guide de prescription des médicaments chez le patient insuffisant rénal. Méditions International, 2005, Paris.