Histopathological and Immunohistochemical Findings in the Lungs of Pigs Infected Experimentally with Mycoplasma hyopneumoniae

Journal of Comparative Pathology

Volumn 140, Issue 4, 2009, Pages 260-270

  Redondo, E ^a   Masot, A J ^a   Fernandez A ^b   Gazquez A ^a  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

Author keywords

Mycoplasma hyopneumoniae; pig; porcine enzootic pneumonia

Indexed keywords

BIOLOGICAL MARKER; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 8; LYSOZYME; TUMOR NECROSIS FACTOR ALPHA;

AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS; CONTROLLED STUDY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS; LUNG ALVEOLUS WALL; LUNG EXTRAVASCULAR FLUID; LUNG INFECTION; LYMPHOID HYPERPLASIA; MYCOPLASMA PNEUMONIAE; MYCOPLASMAL PNEUMONIA OF SWINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BRONCHI; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; LUNG; LYMPHOID TISSUE; MYCOPLASMA HYOPNEUMONIAE; PNEUMONIA OF SWINE, MYCOPLASMAL; SUS SCROFA; SWINE DISEASES;

MYCOPLASMA HYOPNEUMONIAE; SUIDAE; SUS;

EID: 63349106344     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcpa.2008.12.008     Document Type: Article

References (38)

1. Amanfu W., Weng C.N., Ross R.F., and Barnes H.J. Diagnosis of mycoplasmal pneumonia of swine: sequential study by direct immunofluorescence. American Journal of Veterinary Research 45 (1984) 1349-1352
2. Amass S.F., Clark L.K., Van Alstine W.G., Bowersock T.L., Murphy D.A., Knox K.E., and Albregts S.R. Interaction of Mycoplasma hyopneumoniae and Pasteurella multocida infections in swine. American Journal of Veterinary Research 204 (1994) 102-107
3. Asai T., Okada M., Ono M., Irisawa T., Mori Y., Yokomizo Y., and Sato S. Increased levels of tumor necrosis factor and interleukin 1 in bronchoalveolar lavage fluids from pigs infected with Mycoplasma hyopneumoniae. Veterinary Immunology and Immunopathology 38 (1993) 253-260
4. Asai T., Okada M., Ono M., Mori Y., Yokomizo Y., and Sato S. Detection of interleukin-6 and prostaglandin E2 in bronchoalveolar lavage fluids of pigs experimentally infected with Mycoplasma hyopneumoniae. Veterinary Immunology and Immunopathology 44 (1994) 97-102
5. Bereiter M., Young T.F., Joo H.S., and Ross R.F. Evaluation of the ELISA and comparison to the complement fixation test and radial immunodiffusion enzyme assay for detection of antibodies against Mycoplasma hyopneumoniae in swine serum. Veterinary Microbiology 25 (1990) 177-192
6. Choi C., and Chae C. In-situ hybridization for the detection of porcine circovirus in pigs with postweaning multisystemic wasting syndrome. Journal of Comparative Pathology 121 (1999) 265-270
7. Choi C., Kwon D., Jung K., Ha Y., Lee Y.H., Kim O., et al. Expression of inflammatory cytokines in pigs experimentally infected with Mycoplasma hyopneumoniae. Journal of Comparative Pathology 134 (2006) 40-46
8. Friis N.F. Some recommendations concerning primary isolation of M. suipneumoniae and M. flocculare: a survey. Nordisk Veterinaermedicin 27 (1975) 337-339
9. Kwon D., and Chae C. Detection and localization of Mycoplasma hyopneumoniae DNA in lungs from naturally infected pigs by in situ hybridization using a digoxigenin-labeled probe. Veterinary Pathology 36 (1999) 308-313
10. Kwon D., Choi C., and Chae C. Chronologic localization of Mycoplasma hyopneumoniae in experimentally infected pigs. Veterinary Pathology 39 (2002) 584-587
11. Lorenzo H., Quesada O., Assuncao P., Castro A., and Rodríguez F. Cytokine expression in porcine lungs experimentally infected with Mycoplasma hyopneumoniae. Veterinary Immunology and Immunopathology 109 (2006) 199-207
12. Mare C.J., and Switzer W.P. Mycoplasma hyopneumoniae, a causative agent of virus pig pneumonia. Veterinary Medicine 60 (1965) 841-845
13. Mattsson J.G., Bergström K., Wallgren P., and Johansson K.E. Detection of Mycoplasma hyopneumoniae in nose swabs from pigs by in vitro amplification of the 16S rRNA gene. Journal of Clinical Microbiology 33 (1995) 893-897
14. Messier S., and Ross R.F. Interactions of Mycoplasma hyopneumoniae membranes with porcine lymphocytes. American Journal of Veterinary Research 52 (1991) 1497-1502
15. Messier S., Ross R.F., and Paul P.S. Humoral and cellular immune responses of pigs inoculated with Mycoplasma hyopneumoniae. American Journal of Veterinary Research 51 (1990) 52-58
16. Morrison D.F., Foss D.L., and Murtaugh M.P. Interleukin-10 gene therapy-mediated amelioration of bacterial pneumonia. Infection and Immunity 68 (2000) 4752-4758
17. Murtaugh M.P., and Foss D.L. Inflammatory cytokines and antigen presenting cell activation. Veterinary Immunology and Immunopathology 87 (2002) 109-121
18. Nicolet J., Paroz P., and Kristensen B. Growth medium constituents contaminating mycoplasma preparations and their role in the study of membrane glycoproteins in porcine mycoplasmas. Journal of General Microbiology 119 (1980) 17-26
19. Okada M., Asai T., Ono M., Sakano T., and Sato S. Cytological and immunological changes in bronchoalveolar lavage fluid and histological observation of lung lesions in pigs immunized with Mycoplasma hyopneumoniae inactivated vaccine prepared from broth culture supernate. Vaccine 18 (2000) 2825-2831
20. Opriessnig T., Thacker E.L., Yu S., Fenaux M., Meng X.J., and Halbur P.G. Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Veterinary Pathology 41 (2004) 624-640
21. Redondo E., Regodón S., Franco A., Masot J., Gázquez A., and Cardinali D.P. Day-night changes in plasma melatonin levels and ultrastructural properties of pinealocytes in developing female sheep under natural long and short photoperiods. Histology and Histopathology 18 (2003) 333-342
22. Rodríguez F., Quesada O., Poveda J.B., Fernández A.J., and Lorenzo H. Immunohistochemical detection of interleukin-12 and interferon-γ in pigs experimentally infected with Mycoplasma hyopneumoniae. Journal of Comparative Pathology 136 (2007) 79-82
23. Rodríguez F., Ramírez G.A., Sarradell J., Andrada M., and Lorenzo H. Immunohistochemical labelling of cytokines in lung lesions of pigs naturally infected with Mycoplasma hyopneumoniae. Journal of Comparative Pathology 130 (2004) 306-312
24. Sarradell J., Andrada M., Ramírez A.S., Fernández A., Gómez-Villamandos J.C., Jover A., et al. A morphologic and immunohistochemical study of the bronchus-associated lymphoid tissue of pigs naturally infected with Mycoplasma hyopneumoniae. Veterinary Pathology 40 (2003) 395-404
25. Sheldrake R.F., Romalis L.F., and Saunders M.M. Serum and mucosal antibody responses against Mycoplasma hyopneumoniae following intraperitoneal vaccination and challenge of pigs with M. hyopneumoniae. Research in Veterinary Science 55 (1993) 371-376
26. Showkat Rahim S.S., Kahn N., Boddupalli C.S., Hasnain S.E., and Mukhopadhyay S. Interleukin-10 (IL-10) mediated suppression of IL-12 production in AW 264.7 cells also involves c-rel transcription factor. Immunology 114 (2005) 313-321
27. Tajima M., Yagihashi T., Nunoya T., Takeuchi A., and Ohashi F. Mycoplasma hyopneumoniae infection in pigs immunosuppressed by thymectomy and treatment with antithymocyte serum. American Journal of Veterinary Research 45 (1984) 1928-1932
28. Ter Laak E.A., and Noordergraaf J.H. An improved method for the identification of Mycoplasma dispar. Veterinary Microbiology 14 (1987) 25-31
29. Thacker E.L., Thacker B.J., and Janke B.H. Interaction between Mycoplasma hyopneumoniae and swine influenza virus. Journal of Clinical Microbiology 39 (2001) 2525-2530
30. Thacker E.L., Thacker B.J., Young T.F., and Halbur P.G. Effect of vaccination on the potentiation of porcine reproductive and respiratory syndrome virus (PRRSV)-induced pneumonia by Mycoplasma hyopneumoniae. Vaccine 18 (2000) 1244-1252
31. Thanawongnuwech R., and Thacker E.L. Interleukin-10, interleukin-12 and interferon-gamma levels in the respiratory tract following Mycoplasma hyopneumoniae and PRRSV infection in pigs. Viral Immunology 16 (2003) 357-367
32. Thanawongnuwech R., Thacker B., Halbur P., and Thacker E.L. Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae. Clinical Diagnostic and Laboratory Immunology 11 (2004) 901-908
33. Thanawongnuwech R., Young T.F., Thacker B.J., and Thacker E.L. Differential production of proinflammatory cytokines: in vitro PRRSV and Mycoplasma hyopneumoniae co-infection model. Veterinary Immunology and Immunopathology 79 (2001) 115-127
34. Van Reeth K., Van Gucht S.V., and Pensaert M. In vivo studies on cytokine involvement during acute viral respiratory disease of swine: troublesome but rewarding. Veterinary Immunology and Immunopathology 87 (2002) 161-168
35. Vigre H., Dohoo I.R., Stryhn H., and Busch M.E. Intra-unit correlations in seroconversion to Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae at different levels in Danish multi-site pig production facilities. Preventive Veterinary Medicine 63 (2004) 9-28
36. Walker J., Lee R., Mathy N., Doughty S., and Conlon J. Restricted B-cell responses to microbial challenge of the respiratory tract. Veterinary Immunology and Immunopathology 54 (1996) 197-204
37. Wilkie B.N. Respiratory tract immunoresponse to microbial pathogens. American Journal of Veterinary Research 181 (1982) 1074-1079
38. Williams J., Torres-León M.A., and Sansor-Nah R. Prevalencia, extensión y caracterización de las lesiones en el pulmón de cerdos sacrificados en el rastro municipal de Mérida, Yucatán, México. Revista Biomédica 11 (2000) 25-32