Effect of methylenetetrahydrofolate reductase and thymidylate synthase enhancer region polymorphisms on the risk of idiopathic recurrent spontaneous abortion in a Korean population

Fertility and Sterility

Volumn 91, Issue 4 SUPPL., 2009, Pages 1560-1562

  Bae, Jeehyeon ^a,b   Choi, Dong Hee ^a   Kang, Myung Seo ^a   Cha, Sun Hee ^a   Oh, Doyeun ^a   Kim, Nam Keun ^a  

^a Bundang CHA Hospital   (South Korea)

^b CHA University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); THYMIDYLATE SYNTHASE;

ADULT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE MUTATION; GENOTYPE; HAPLOTYPE; HUMAN; IDIOPATHIC DISEASE; KOREA; MAJOR CLINICAL STUDY; POPULATION RESEARCH; PRIORITY JOURNAL; RECURRENT DISEASE; RISK ASSESSMENT; SPONTANEOUS ABORTION;

ABORTION, SPONTANEOUS; ADULT; CASE-CONTROL STUDIES; ENHANCER ELEMENTS, GENETIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; KOREA; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; RECURRENCE; RISK FACTORS; THYMIDYLATE SYNTHASE;

EID: 63249134703     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.09.060     Document Type: Article

References (7)

1. Stirrat G.M. Recurrent miscarriage. Lancet 336 (1990) 673-675
2. Nelen W.L., Blom H.J., Steegers E.A., den Heijer M., and Eskes T.K. Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis. Fertil Steril 74 (2000) 1196-1199
3. Kim N.K., Choi Y.K., Kang M.S., Choi D.H., Cha S.H., An M.O., et al. Influence of combined methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase enhancer region (TSER) polymorphisms to plasma homocysteine levels in Korean patients with recurrent spontaneous abortion. Thromb Res 117 (2006) 653-658
4. Ren A., and Wang J. Methylenetetrahydrofolate reductase C677T polymorphism and the risk of unexplained recurrent pregnancy loss: a meta-analysis. Fertil Steril 86 (2006) 1716-1722
5. Selhub J. Homocysteine metabolism. Annu Rev Nutr 19 (1999) 217-246
6. Horie N., Aiba H., Oguro K., Hojo H., and Takeishi K. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct 20 (1995) 191-197
7. INK4Aand hMLH1 genes in spontaneously aborted embryos with normal chromosomal integrity. Fertil Steril 90 (2008) 1605-1610