Development and validation of a HPLC method for simultaneous quantitation of gatifloxacin, sparfloxacin and moxifloxacin using levofloxacin as internal standard in human plasma: Application to a clinical pharmacokinetic study

Biomedical Chromatography

Volumn 22, Issue 11, 2008, Pages 1288-1295

  Srinivas, Nimmagadda ^a,b   Narasu, Lakshmi ^b   Shankar, B Prabha ^c   Mullangi, Ramesh ^d  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^b Exhibition Grounds   (India)

^c Eurodrug Laboratories India   (India)

^d DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Fluoroquinolones; Gatifloxacin; HPLC; Human plasma; Levofloxacin; Moxifloxacin; Pharmacokinetics; Sparfloxacin; Validation

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PLASMA (HUMAN);

FLUOROQUINOLONES; GATIFLOXACIN; HPLC; HPLC METHOD; HUMAN PLASMAS; INTERNAL STANDARDS; LEVOFLOXACIN; MOXIFLOXACIN; SPARFLOXACIN; VALIDATION;

PHARMACOKINETICS;

ACETIC ACID ETHYL ESTER; ACETONITRILE; GATIFLOXACIN; LEVOFLOXACIN; MOXIFLOXACIN; PHOSPHATE; SPARFLOXACIN;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELUTION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; SENSITIVITY AND SPECIFICITY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

EID: 63249130988     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1060     Document Type: Article

References (7)

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