Immunotherapy of 347 volunteer outpatient morphine addicts by human therapeutic morphine vaccine in Kermanshah province of Iran

Journal of Pharmacology and Toxicology

Volumn 4, Issue 1, 2009, Pages 30-35

  Akbarzadeh, Azim ^a   Norouzian, D ^a   Farhangi, A ^a   Mehrabi, M ^a   Chiani, M ^a   Zare, D ^a   Saffari, Z ^a   Mortazavi, M ^a   Nikdel, A ^a  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Clinical trial; Morphine vaccine; Vaccination; Volunteer addicts

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALUMINUM HYDROXIDE; AMPHETAMINE; CANNABIS; COCAINE; DIAMORPHINE; DISODIUM HYDROGEN PHOSPHATE; IMMUNOGLOBULIN; MORPHINE 6 SUCCINATE; MORPHINE VACCINE; OPIATE; PROTEIN; SODIUM CHLORIDE; SODIUM DIHYDROGEN PHOSPHATE; SUCCINIC ACID; UNCLASSIFIED DRUG; VACCINE; WATER TRANSPORT AGENT;

ADOLESCENT; ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DRUG HYPERSENSITIVITY; DRUG METABOLISM; DRUG TOLERABILITY; EDEMA; ELECTROPHORESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHEMA; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOTHERAPY; IRAN; MAJOR CLINICAL STUDY; MALE; MORPHINE ADDICTION; PATIENT MONITORING; PROTEIN BLOOD LEVEL; TREATMENT DURATION; VACCINATION;

EID: 63249130019     PISSN: 1816496X     EISSN: None     Source Type: Journal    
DOI: 10.3923/jpt.2009.30.35     Document Type: Article

References (11)

1. Akbarzadeh, A., M. Mehraby, M. Zarbakhsh and H. Farzaneh, 1999. Design and synthesis of a morphine-6-succinyl-bovine serum albumin hapten for vaccine development. Biotechnol. Applied Biochem., 30: 139-145.
2. Akbarzadeh, A., D. Norouzian and B. Farahmand, 2001. Rapid latex Agglutination inhibition reaction test for morphine in biological fluid. J. Sabzevar School Med. Sci., 9: 10-19.
3. Akbarzadeh, A., D. Norouzian, B. Farahmand and D. Nouri Inanlou, 2002. Rapid Latex agglutination inhibition reaction test for morphine in urine. Curr. Sci., 83: 57-60.
4. Akbarzadeh, A., D. Norouzian, B. Farahmand, P. Afshar, S.J. Vaez and A. Farhangi, 2003. Immunotherapy of 1200 addicts to morphine by morphine vaccine. J. Sabzevar School Med. Sci., 10: 6-22.
5. Akbarzadeh, A., D. Norouzian, M.R. Mehrabi, A. Farhangi, S.M. Atyabi and D. Zare, 2007a. Safety and Immunogenicity of human therapeutic morphine vaccine in morphine addicts. J. Sabzevar School Med. Sci., 10: 23-31.
6. Akbarzadeh, A., D. Norouzian, A. Farhangi, M.R. Mehrabi, M. Bakhtiari and P. Afshar et al., 2007b. Study of human therapeutic morphine vaccine: Safety and immunogenicity. Asain J. Biochem., 2: 58-65.
7. Berrettini, W.H. and C.E. Lerman, 2005. Pharmacotherapy and pharmacokinetics of nicotine dependence. Am. J. Psychiatry, 162: 1441-1451.
8. Keyler, D.E., M.B. Dufek, A.D. Calvin, T.J. Bramwell and M.G. Lesage et al., 2005. Reduced nicotine distribution from mother to fetal brain in rats vaccinated against nicotine: Time course and influence of nicotine dosing regimen. Biochem. Pharmacol., 69: 1385-1395.
9. Mihãltan, F., 2007. The vaccine against nicotine-the future for smoking cessation? Pneumologia, 56: 101-103.
10. Tobin, J., Dickerson, K.D. and Janda, 2005. Recent advances for the treatment of cocaine abuse: Central nervous system immunopharmacotherapy. The AAPS J., 7: 579-587.
11. Vocci, F.J. and C.N. Chiang, 2001. Vaccines against nicotine: how effective are they likely to be in preventing smoking? CNS Drugs, 15: 505-514.