The effect of selective estrogen receptor modulator administration on the hypothalamic-pituitary-testicular axis in men with idiopathic oligozoospermia

Fertility and Sterility

Volumn 91, Issue 4 SUPPL., 2009, Pages 1427-1430

  Tsourdi, Elena ^a   Kourtis, Anargyros ^a   Farmakiotis, Dimitrios ^a   Katsikis, Ilias ^a   Salmas, Marios ^a   Panidis, Dimitrios ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; RALOXIFENE; TAMOXIFEN; TESTOSTERONE; TOREMIFENE;

ADULT; ARTICLE; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; GONADOTROPIN RELEASE; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IDIOPATHIC DISEASE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OLIGOSPERMIA; PRIORITY JOURNAL; SUBFERTILITY; TESTIS; TESTOSTERONE BLOOD LEVEL;

ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; FOLLICLE STIMULATING HORMONE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LUTEINIZING HORMONE; MALE; MIDDLE AGED; OLIGOSPERMIA; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SPERM COUNT; SPERM MOTILITY; TAMOXIFEN; TESTIS; TESTOSTERONE; TOREMIFENE;

EID: 63249102877     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.06.002     Document Type: Article

References (18)

1. Plouffe Jr. L., and Siddhanti S. The effect of selective estrogen receptor modulators on parameters of the hypothalamic-pituitary-gonadal axis. Ann NY Acad Sci 949 (2001) 251-258
2. Plouffe Jr. L. Selective estrogen receptor modulators (SERMs) in clinical practice. J Soc Gynecol Investig 7 (2000) S38-S46
3. Riggs B.L., and Hartmann L.C. Selective estrogen receptor modulators. Mechanisms of action and application to clinical practice. N Engl J Med 348 (2003) 618-629
4. Adashi E.Y. Ovulation induction: clomiphene citrate. In: Adashi E.Y., and Rosenwaks J.A. (Eds). Reproductive endocrinology, surgery, and technology (1996), Lippincott-Raven, Philadelphia 1181-1206
5. Comhaire F. Treatment of oligozoospermia with tamoxifen. Int J Fertil 21 (1976) 232-238
6. Buvat J., Ardaens K., Lemaire A., Gauthier A., Gasnault J.P., and Buvat-Herbaut M. Increased sperm count in 25 cases of idiopathic normozoospermic oligospermia following treatment with tamoxifen. Fertil Steril 39 (1983) 700-703
7. Kotoulas I.G., Cardamakis E., Michopoulos J., Mitropoulos D., and Dounis A. Tamoxifen treatment in male infertility. I. Effect on spermatozoa. Fertil Steril 61 (1994) 911-914
8. Comhaire F., Milingos S., Liapi A., Gordts S., Campo R., Depypere H., et al. The effective cumulative pregnancy rate of different modes of treatment of male infertility. Andrologia 27 (1995) 217-221
9. Comhaire F., Zalata A., and Mahmoud A. Critical evaluation of the effectiveness of different modes of treatment of male infertility. Andrologia 28 (1996) 31-35
10. Adamopoulos D.A., Nicopoulou S., Kapolla N., Karamertzanis M., and Andreou E. The combination of testosterone undecanoate with tamoxifen citrate enhances the effect of each agent given independently on seminal parameters in men with idiopathic oligozoospermia. Fertil Steril 67 (1997) 756-762
11. Adamopoulos D., Pappa A., Billa E., Nicopoulou S., Koukkou E., and Michopoulos J. Effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in men with idiopathic oligozoospermia. Fertil Steril 80 (2003) 914-920
12. Rowe P., Comhaire F., Hargreave T., and Mahmoud A. World Health Organisation manual for the standardized investigation, diagnosis and management of the infertile male (2000), Cambridge University Press, Cambridge 37-60
13. Farmakiotis D., Farmakis C., Rousso D., Kourtis A., Katsikis I., and Panidis D. The beneficial effects of toremifenee administration on the hypothalamic-pituitary-testicular axis and sperm parameters in men with idiopathic oligozoospermia. Fertil Steril 88 (2007) 847-853
14. Kangas L. Review of the pharmacological properties of toremifene. J Steroid Biochem 36 (1990) 191-195
15. Labrie F., Labrie C., Belanger A., Simard J., Gauthier S., Luu-The V., et al. EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium. J Steroid Biochem Mol Biol 69 (1999) 51-84
16. Duschek E.J., Neele S.J., Thomassen M.C., Rosing J., and Netelenbos C. Effect of raloxifene on activated protein C (APC) resistance in postmenopausal women and homocysteine levels in elderly men: two randomized placebo-controlled studies. Blood Coag Fibrinolysis 15 (2004) 649-655
17. Zalaka A., Hafez T., Verdonck L., Vermoulen L., and Comhaire F. Androgens in seminal plasma: markers of the surface epithelium on the male genital tract. Int J Androl 18 (1995) 271-277
18. Smals A.G.H., Pieters G.F.M., and Drayer J.I.M. Tamoxifen suppresses gonadotropin-induced 16-alpha-hydroxy-progesterone accumulation in normal men. J Clin Endocrinol Metab 51 (1980) 1026-1029