A lesson in tolerance - maternal instruction to fetal cells

New England Journal of Medicine

Volumn 360, Issue 13, 2009, Pages 1355-

  Burlingham, William J ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; ALLOANTIGEN;

ARTICLE; AUTOIMMUNITY; CD4 LYMPHOCYTE COUNT; HUMAN; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; LYMPH NODE; MICROCHIMERISM; NATURAL KILLER CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; STEM CELL; CHIMERA; FEMALE; FETOMATERNAL TRANSFUSION; FETUS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PREGNANCY; THYMUS;

CHIMERISM; FEMALE; FETUS; HUMANS; IMMUNE TOLERANCE; ISOANTIGENS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MATERNAL-FETAL EXCHANGE; PREGNANCY; SELF TOLERANCE; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND;

EID: 63249089059     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr0810752     Document Type: Article

References (5)

1. Mold JE, Michaelsson J, Burt TD, et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 2008;322:1562-5.
2. Streilein JW. Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat Rev Immunol 2003;3: 879-89.
3. Burlingham WJ, Grailer AP, Heisey DM, et al. The effect of tolerance to noninherited maternal HLA antigens on the survival of renal transplants from sibling donors. N Engl J Med 1998; 339:1657-64.
4. van Rood JJ, Loberiza FR Jr, Zhang MJ, et al. Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling. Blood 2002;99: 1572-7.
5. Molitor-Dart ML, Andrassy J, Kwun J, et al. Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance. J Immunol 2007;179:6749-61.