A case of Takotsubo cardiomyopathy during 5-fluorouracil treatment for rectal adenocarcinoma

Journal of Nippon Medical School

Volumn 76, Issue 1, 2009, Pages 27-33

  Kobayashi, Nobuaki ^a,b   Hata, Noritake ^a,b   Yokoyama, Shinya ^a,b   Shinada, Takuro ^a,b   Shirakabe, Akihiro ^a,b   Mizuno, Kyoichi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b NIPPON MEDICAL SCHOOL CHIBA HOKUSOH HOSPITAL   (Japan)

Author keywords

5 fluorouracil; Acute heart failure; Coronary vasospasm; Microcirculation disorders; Takotsubo cardiomyopathy

Indexed keywords

ACETYLCHOLINE; ANTINEOPLASTIC AGENT; FLUOROURACIL; FOLINIC ACID; FUROSEMIDE; GLYCERYL TRINITRATE; LEVOFOLINATE CALCIUM; NIFEDIPINE; UNCLASSIFIED DRUG;

ACUTE HEART FAILURE; ADULT; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD PRESSURE; BREATHING RATE; CANCER CHEMOTHERAPY; CASE REPORT; CONVALESCENCE; CORONARY ARTERY; CORONARY ARTERY SPASM; DRUG INFUSION; DYSPNEA; ELECTROCARDIOGRAM; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW UP; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART RATE; HEART SCINTISCANNING; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; QT PROLONGATION; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM CARCINOMA; SMOKING; ST SEGMENT ELEVATION; T WAVE; TAKOTSUBO CARDIOMYOPATHY; THORAX PAIN;

ADENOCARCINOMA; ANTIMETABOLITES, ANTINEOPLASTIC; FEMALE; FLUOROURACIL; HEART FAILURE; HUMANS; MIDDLE AGED; RECTAL NEOPLASMS; TAKOTSUBO CARDIOMYOPATHY;

EID: 63149183887     PISSN: 13454676     EISSN: 13473409     Source Type: Journal    
DOI: 10.1272/jnms.76.27     Document Type: Article

References (22)

1. Carpenter ME: 5-fluorouracil intravenously and tachycardia. Br Med J 1972; 4: 192.
2. Dent RG, McColl I: Letter: 5-Fluorouracil and angina. Lancet 1975; 1: 347-348.
3. Burger AJ, Mannino S: 5-Fluorouracil-induced coronary vasospasm. Am Heart J 1987; 114: 433-436.
4. Maseri A, Lanza G: Fluorouracil-induced coronary artery spasm. Am J Med 2001; 111: 326-327.
5. Tutkun A, Inanli S, Caymaz O, Ayanoglu E, Duman D: Cardiotoxicity of 5-flourouracil: two case reports. Auris Nasus Larynx 2001; 28: 193-196.
6. Lestuzzi C, Viel E, Picano E, Meneguzzo N: Coronary vasospasm as a cause of effort-related myocardial ischemia during low-dose chronic continuous infusion of 5-fluorouracil. Am J Med 2001; 111: 316-318.
7. Luwaert RJ, Descamps O, Majois F, Chaudron JM, Beauduin M: Coronary artery spasm induced by 5-fluorouracil. Eur Heart J 1991; 12: 468-470.
8. Labianca R, Beretta G, Clerici M, Fraschini P, Luporini G: Cardiac toxicity of 5-fluorouracil: a study on 1083 patients. Tumori 1982; 68: 505-510.
9. Gibson CM, Cannon CP, Daley WL, et al.: TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 1996; 93: 879-888.
10. Mosseri M, Fingert HJ, Varticovski L, Chokshi S, Isner JM: In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle. Cancer Res 1993; 53: 3028-3033.
11. Sudhoff T, Enderle MD, Pahlke M, et al.: 5-Fluorouracil induces arterial vasocontractions. Ann Oncol 2004; 15: 661-664.
12. Chaudary S, Song SY, Jaski BE: Profound, yet reversible, heart failure secondary to 5-fluorouracil. Am J Med 1988; 85: 454-456.
13. David JS, Gueugniaud PY, Hepp A, Gaussorgues P, Petit P: Severe heart failure secondary to 5-fluorouracil and low-doses of folinic acid: usefulness of an intra-aortic balloon pump. Crit Care Med 2000; 28: 3558-3560.
14. Sato M, Fujita S, Saito A, et al.: Increased incidence of transient left ventricular apical ballooning (so-called 'Takotsubo' cardiomyopathy) after the mid-Niigata Prefecture earthquake. Circ J 2006; 70: 947-953.
15. Tsuchihashi K, Ueshima K, Uchida T, et al.: Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. Angina Pectoris-Myocardial Infarction Investigations in Japan. J Am Coll Cardiol 2001; 38: 11-18.
16. Tsibiribi P, Bui-Xuan C, Bui-Xuan B, et al.: Cardiac lesions induced by 5-fluorouracil in the rabbit. Hum Exp Toxicol 2006; 25: 305-309.
17. Bybee KA, Prasad A, Barsness GW, et al.: Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome. Am J Cardiol 2004; 94: 343-346.
18. Nishikawa S, Ito K, Adachi Y, Katoh S, Azuma A, Matsubara H: Ampulla ('takotsubo') cardiomyopathy of both ventricles: evaluation of microcirculation disturbance using 99mTc-tetrofosmin myocardial single photon emission computed tomography and doppler guide wire. Circ J 2004; 68: 1076-1080.
19. Kume T, Akasaka T, Kawamoto T, et al.: Assessment of coronary microcirculation in patients with takotsubo-like left ventricular dysfunction. Circ J 2005; 69: 934-939.
20. Kawai S, Kitabatake A, Tomoike H: Guidelines for diagnosis of takotsubo (ampulla) cardiomyopathy. Circ J 2007; 71: 990-992.
21. Kurisu S, Sato H, Kawagoe T, et al.: Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction. Am Heart J 2002; 143: 448-455.
22. Abe Y, Kondo M, Matsuoka R, Araki M, Dohyama K, Tanio H: Assessment of clinical features in transient left ventricular apical ballooning. J Am Coll Cardiol 2003; 41: 737-742.