An in vitro investigation of herbs traditionally used for kidney and urinary system disorders: Potential therapeutic and toxic effects

Nephrology

Volumn 14, Issue 1, 2009, Pages 70-79

  Wojcikowski, Ken ^a,b   Wohlmuth, Hans ^b   Johnson, David W ^a   Rolfe, Margaret ^b   Gobe, Glenda ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b SOUTHERN CROSS UNIVERSITY   (Australia)

Author keywords

Apoptosis; Fibroblasts; Herbal; Medicinal plant; Renal pathology; Sequential extraction

Indexed keywords

ACETIC ACID ETHYL ESTER; ACHILLEA MILLEFOLIUM EXTRACT; AGRIMONIA EUPATORIA EXTRACT; ALPHA SMOOTH MUSCLE ACTIN; ANGELICA ARCHANGELICA EXTRACT; ANGELICA EXTRACT; ANGELICA SINENSIS EXTRACT; APIUM GRAVEOLENS EXTRACT; ARCTOSTAPHYLOS UVA URSI EXTRACT; ARTEMISIA ARBORESCENS EXTRACT; ASTRAGALUS MEMBRANACEUS EXTRACT; BUPLEURUM FALCATUM EXTRACT; CENTELLA ASIATICA EXTRACT; CIMICIFUGA RACEMOSA EXTRACT; CINNAMOMUM VERNUM EXTRACT; CURCUMA LONGA EXTRACT; DIOSCOREA VILLOSA EXTRACT; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; GLYCYRRHIZA GLABRA EXTRACT; GREEN TEA EXTRACT; HERBACEOUS AGENT; HYDROGEN PEROXIDE; INULA HELENIUM EXTRACT; JUNIPERUS COMMUNIS EXTRACT; LEVISTICUM OFFICINALE EXTRACT; METHANOL; SCUTELLARIA LATERIFLORA EXTRACT; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UNINDEXED DRUG; URINARY TRACT AGENT;

ACHILLEA; AGRIMONIA; AGRIMONIA EUPATORIA; ANGELICA ARCHANGELICA; ANGELICA SINENSIS; ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARCTOSTAPHYLOS UVA URSI; ARTEMISIA; ARTEMISIA ARBORESCENS; ARTICLE; ASTRAGALUS MEMBRANACEUS; BUPLEURUM; BUPLEURUM FALCATUM; CELERY; CELL CULTURE; CELL DEATH; CELL TRANSDIFFERENTIATION; CENTELLA ASIATICA; CIMICIFUGA RACEMOSA; CINNAMOMUM; CINNAMOMUM VERNUM; CURCUMA LONGA; CYTOTOXICITY; DIOSCOREA VILLOSA; DRUG EFFECT; ELECAMPANE; ELEUTHEROCOCCUS SENTICOSUS; GLYCYRRHIZA GLABRA; HERB; IMMUNOHISTOCHEMISTRY; INULA; JUNIPERUS; KIDNEY DISEASE; KIDNEY FIBROSIS; LEVISTICUM; LEVISTICUM OFFICINALE; MITOSIS; NECROSIS; NONHUMAN; OLIVE TREE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SCUTELLARIA; SCUTELLARIA LATERIFLORA; SOLVENT EXTRACTION; TEA; URINARY TRACT DISEASE; YAM;

ACTINS; ANIMALS; APOPTOSIS; CELLS, CULTURED; KIDNEY DISEASES; PHYTOTHERAPY; PLANT EXTRACTS; RATS; TRANSFORMING GROWTH FACTOR BETA1; UROLOGIC DISEASES;

EID: 63149168047     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2008.01017.x     Document Type: Article

References (29)

1. Xue JL, Ma JZ, Louis TA, Collins AJ. Forecast of the number of patients with end-stage renal disease in the United States to the year 2010. J. Am. Soc. Nephrol. 2001 12 : 2753 8.
2. Yu L, Noble NA, Border WA. Therapeutic strategies to halt renal fibrosis. Curr. Opin. Pharmacol. 2002 2 : 177 81.
3. Meguid El Nahas A, Bello AK. Chronic kidney disease: The global challenge. Lancet 2005 365 : 331 40.
4. Laplante P, Raymond MA, Gagnon G et al. Novel fibrogenic pathways are activated in response to endothelial apoptosis: Implications in the pathophysiology of systemic sclerosis. J. Immunol. 2005 174 : 5740 49.
5. Jaber BL, Madias NE. Progression of chronic kidney disease: Can it be prevented or arrested? Am. J. Med. 2005 118 : 1323 30.
6. Yang T, Vesey DA, Johnson DW, Wei MQ, Gobe GC. Apoptosis of tubulointerstitial chronic inflammatory cells in progressive renal fibrosis after cancer therapies. Transl. Res. 2007 150 : 40 50.
7. Lane A, Johnson DW, Pat B et al. Interacting roles of myofibroblasts, apoptosis and fibrogenic growth factors in the pathogenesis of renal tubulo-interstitial fibrosis. Growth Factors 2002 20 : 109 19.
8. Balachandran P, Wei F, Lin R-C, Khan IA, Pasco DS. Structure activity relationships of aristolochic acid analogues: Toxicity in cultured renal epithelial cells. Kidney Int. 2005 67 : 1797 805.
9. Pozdzik AA, Salmon IJ, Debelle FD et al. Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation. Kidney Int. 2008 73 : 595 607.
10. Wojcikowski K, Johnson DW, Gobe G. Herbs or natural substances as complementary therapies for chronic kidney disease: Ideas for future studies. J. Lab. Clin. Med. 2006 147 : 160 66.
11. Raskin I, Ribnicky DM, Komarnytsky S, Ilic N et al. Plants and human health in the twenty-first century. Trends Biotechnol. 2002 20 : 522 31.
12. Huang X, Kong L, Li X, Chen X, Guo M, Zou H. Strategy for analysis and screening of bioactive compounds in traditional Chinese medicines. J. Chromat. 2004 812 : 71 84.
13. Walker NI, Harmon BV, Gobe GC, Kerr JF. Patterns of cell death. Methods Achiev. Exp. Pathol. 1988 13 : 18 54.
14. Kerr JF, Gobe GC, Winterford CM, Harmon BV. Anatomical methods in cell death. Methods Cell Biol. 1995 46 : 1 27.
15. Pat B, Hughson MB, Nicol J, Hoy WE, Gobe GC. A comparison of pathomolecular markers of fibrosis and morphology in kidney from autopsies of African Americans and whites. Virchows Arch. 2007 450 : 41 50.
16. Wojcikowski K, Stevenson L, Leach D, Wohlmuth H, Gobe G. Antioxidant capacity of 55 medicinal herbs traditionally used to treat the urinary system: A comparison using a sequential three-solvent extraction process. J. Altern. Complement. Med. 2007 13 : 103 9.
17. Bhandari MR, Kawabata J. Bitterness and toxicity in wild yam (Dioscorea spp.) tubers of Nepal. Plant Foods Hum. Nutr. 2005 60 : 129 35.
18. Tan X-q, Ruan J-l, Chen H-s, Wang J-y. Studies on liver-toxicity in rhigoma of Dioscorea bulbifera. Zhongguo Zhong Yao Za Zhi/Zhongguo Zhongyao Zazhi/China J. Chin. Mater. Med. 2003 28 : 661 3.
19. Prud'homme GJ. Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations. Lab. Invest. 2007 87 : 1077 91.
20. Groma V Demonstration of collagen type VI and alpha-smooth muscle actin in renal fibrotic injury in man. Nephrol. Dial. Transplant. 1998 13 : 305 12.
21. Webster J, Beck W, Ternai B. Toxicity and bitterness in Australian Dioscorea bulbifera and Dioscorea hispida from Thailand. J. Agric. Food Chem. 1984 32 : 1087 90.
22. Anonymous. Final report of the amended safety assessment of Dioscorea Villosa (Wild Yam) root extract. Int. J. Toxicol. 2004 23 (Suppl 2 49 54.
23. Bonkovsky HL. Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis). Ann. Intern. Med. 2006 144 : 68 71.
24. Qureshi S, Shah AH, Ageel AM. Toxicity studies on Alpinia galanga and Curcuma longa. Planta Med. 1992 58 : 124 7.
25. Bille N, Larsen JC, Hansen EV, Wurtzen G. Subchronic oral toxicity of turmeric oleoresin in pigs. Food. Chem. Toxicol. 1984 23 : 967 73.
26. Kandarkar SV, Sawant SS, Ingle AD, Deshpande SS, Maru GB. Subchronic oral hepatotoxicity of turmeric in mice - histopathological and ultrastructural studies. Indian J. Exp. Biol. 1998 36 : 675 9.
27. Pak Y, Patek R, Mayersohn M. Sensitive and rapid isocratic liquid chromatography method for the quantitation of curcumin in plasma. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2003 796 : 339 46.
28. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: A short review. Life Sci. 2006 78 : 2081 7.
29. Gou YL, Ho ALS, Rowlands DK, Chung YW, Chan HC. Effects of Bak Foong Pill on blood coagulation and platelet aggregation. Biol. Pharm. Bull. 2003 26 : 241 6.