Thoracic spine compression fracture during isoniazid-induced seizures: Case report

Pediatric Emergency Care

Volumn 24, Issue 12, 2008, Pages 842-844

  Kalac, Aydner ^a   Duru, Mehmet ^a   Karazincir, Sinem ^a   Sevinç, Teoman Toni ^a   Kuvandk, Güven ^a   Balc, Ali ^a  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

Author keywords

Isoniazid; Seizures; Spine compression fracture

Indexed keywords

ACTIVATED CARBON; ISONIAZID; PYRIDOXINE; 4 AMINOBUTYRIC ACID; ANTIDOTE; CHARCOAL;

ARTICLE; BACKACHE; BRACE; CASE REPORT; CHILD; COMPRESSION FRACTURE; CONFUSION; EMERGENCY CARE; FEMALE; GRAND MAL SEIZURE; HUMAN; METABOLIC ACIDOSIS; PHYSIOTHERAPY; SCHOOL CHILD; SPINE RADIOGRAPHY; STOMACH LAVAGE; THORACIC SPINE; TONIC CLONIC SEIZURE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; GRAND MAL EPILEPSY; INJURY; INTOXICATION; MUSCLE SPASM; RADIOGRAPHY; SPINE FRACTURE; VERTEBRA;

ANTIDOTES; BACK PAIN; CHARCOAL; CHILD; EPILEPSY, TONIC-CLONIC; FEMALE; FRACTURES, COMPRESSION; GAMMA-AMINOBUTYRIC ACID; HUMANS; ISONIAZID; OVERDOSE; PYRIDOXINE; SPASM; SPINAL FRACTURES; THORACIC VERTEBRAE;

EID: 63149167476     PISSN: 07495161     EISSN: None     Source Type: Journal    
DOI: 10.1097/PEC.0b013e31818ea0a5     Document Type: Article

References (24)

1. Buck D, Baker GA, Jacoby A, et al. Patients' experiences of injury as a result of epilepsy. Epilepsia. 1997;38:439-444.
2. Finelli PF, Cardi JK. Seizure as a cause of fracture. Neurology. 1989;39:858-860.
3. Kumar SK, Freeman BJ. Quadriplegia following grand mal seizures. Injury. 1999;30:626-629.
4. Vernay D, Dubost JJ, Dordain G, et al. Seizures and compression fracture. Neurology. 1990;40:725-726.
5. McCullen GM, Brown CC. Seizure-induced thoracic burst fractures. A case report. Spine. 1994;19:77-79.
6. Youssef JA, McCullen GM, Brown CC. Seizure-induced lumbar burst fracture. Spine. 1995;20:1301-1303.
7. Roohi F, Fox A. Burst fracture of the first lumbar vertebra and conus-cauda syndrome complicating a single convulsive seizure: a challenge of diagnosis in the emergency department. J Emerg Med. 2006;31:381-385.
8. Takahashi T, Tominaga T, Shamoto H, et al. Seizure-induced thoracic spine compression fracture: case report. Surg Neurol. 2002;58:214-216.
9. Alvarez FG, Guntupalli KK. Isoniazid overdose: four case reports and review of the literature. Intensive Care Med. 1995;21:641-644.
10. Watkins RC, Hambrick EL, Benjamin G, et al. Isoniazid toxicity presenting as seizures and metabolic acidosis. J Natl Med Assoc. 1990;82:57-64.
11. Shannon MW. Isoniazid. In: Haddad LM, Shannon MW, Winchester JF, eds. Clinical Management of Poisoning and Drug Overdose. 3rd ed. Philadelphia, PA: WB Saunders Co;1998:721-726.
12. Shah BR, Santucci K, Sinert R, et al. Acute isoniazid neurotoxicity in an urban hospital. Pediatrics. 1995;95:700-704.
13. Romero JA, Kuczler FJ Jr. Isoniazid overdose: recognition and management. Am Fam Physician. 1998;57:749-752.
14. Temmerman W, Dhondt A, Vandewoude K. Acute isoniazid intoxication: seizures, acidosis and coma. Acta Clin Belg. 1999;54:211-216.
15. Lheureux P, Penaloza A, Gris M. Pyridoxine in clinical toxicology: a review. Eur J Emerg Med. 2005;12:78-85.
16. Longmore M, Wilkinson B, Rajagopalan S. Emergencies. In: Oxford Handbook of Clinical Medicine. 6th ed. Oxford, United Kingdom: Oxford University Press; 2004:826-828.
17. Vale JA. Position statement: gastric lavage. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. J Toxicol Clin Toxicol. 1997;35:711-719.
18. Chyka PA, Seger D. Position statement: single-dose activated charcoal. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. J Toxicol Clin Toxicol. 1997;35:721-741.
19. Siefkin AD, Albertson TE, Corbett MG. Isoniazid overdose: pharmacokinetics and effects of oral charcoal in treatment. Hum Toxicol. 1987;6:497-501.
20. Orlowski JP, Paganini EP, Pippenger CE. Treatment of a potentially lethal dose isoniazid ingestion. Ann Emerg Med. 1988;17:73-76.
21. Cash JM, Zawada ET Jr. Isoniazid overdose. Successful treatment with pyridoxine and hemodialysis. West J Med. 1991;155:644-646.
22. Gospe SM Jr, Bell RM. Hospital pharmacy and emergency department availability of parenteral pyridoxine. Pediatr Emerg Care. 2005;21:586-588.
23. Pedersen KK, Christiansen C, Ahlgren P, et al. Incidence of fractures of the vertebral spine in epileptic patients. Acta Neurol Scand. 1976;54:200-203.
24. Vasconcelos D. Compression fractures of the vertebrae during major epileptic seizures. Epilepsia. 1973;14:323-328.