Synthesis of novel 1,3-diacetoxy-acridones as cytotoxic agents and their DNA-binding studies

Scientia Pharmaceutica

Volumn 77, Issue 1, 2009, Pages 19-32

  Sathish, N K ^a   Prasad, V V S Rajendra ^a   Raghavendra, N M ^b   Kumar, S M Shanta ^a   Mayur, Y C ^a  

^a V L COLLEGE OF PHARMACY   (India)

^b ACHARYA AND B M REDDY COLLEGE OF PHARMACY   (India)

Author keywords

1,3 diacetoxyacridone; Calf thymus DNA; Cytotoxicity; Dna binding; HL 60; MCF 7

Indexed keywords

10 (3 MORPHOLIN 4 YLBUTYL) 9 OXO 9,10 DIHYDROACRIDINE 1,3 DIYL DIACETATE; 10 [3 (4 METHYLPIPERAZIN 1 YL)BUTYL] 9 OXO 9,10 DIHYDROACRIDINE 1,3 DIYL DIACETATE; 10 [3 (DIETHYLAMINO)BUTYL] 9 OXO 9,10 DIHYDROACRIDINE 1,3 DIYL DIACETATE; 10 [3 (DIETHYLAMINO)PROPYL] 9 OXO 9,10 DIHYDROACRIDINE 1,3 DIYL DIACETATE; 10 [4 [4 (2 HYDROXYETHYL)PIPERAZIN 1 YL]BUTYL] 9 OXO 9,10 DIHYDROACRIDINE 1,3 DIYL DIACETATE; 9 OXO 10 (3 PIPERIDIN 1 YLBUTYL) 9,10 DIHYDROACRIDINE 1,3 DIYL DIACETATE; ACRIDONE DERIVATIVE; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DOXORUBICIN; PIPERIDINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CELL STRAIN HL 60; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INTERCALATION COMPLEX; LIPOPHILICITY; STRUCTURE ACTIVITY RELATION;

EID: 63149166733     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.0811-03     Document Type: Article

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