Direct interaction of Dysbindin with the AP-3 complex via its μ subunit

Neurochemistry International

Volumn 54, Issue 7, 2009, Pages 431-438

  Taneichi Kuroda, Setsuko ^a   Taya, Shinichiro ^a,b   Hikita, Takao ^a,b   Fujino, Yasutaka ^a,b   Kaibuchi, Kozo ^a,b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

AP 3 complex; Dysbindin; Schizophrenia

Indexed keywords

ADAPTOR PROTEIN; DYSBINDIN; MU ADAPTIN;

ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HIPPOCAMPUS; MOUSE; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ADAPTOR PROTEIN COMPLEX 3; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; DNA, COMPLEMENTARY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GLUTATHIONE TRANSFERASE; HIPPOCAMPUS; HISTIDINE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICE; MICE, INBRED DBA; NEUROTRANSMITTER AGENTS; PREGNANCY; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SYNAPTIC VESICLES; TUBULIN;

EID: 63149138208     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.01.014     Document Type: Article

References (35)

1. Bellon A. New genes associated with schizophrenia in neurite formation: a review of cell culture experiments. Mol. Psychiatry 12 (2007) 620-629
2. Benson M.A., Newey S.E., Martin-Rendon E., Hawkes R., and Blake D.J. Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. J. Biol. Chem. 276 (2001) 24232-24241
3. Bonifacino J.S., and Dell'Angelica E.C. Molecular bases for the recognition of tyrosine-based sorting signals. J. Cell Biol. 145 (1999) 923-926
4. Chen X.W., Feng Y.Q., Hao C.J., Guo X.L., He X., Zhou Z.Y., Guo N., Huang H.P., Xiong W., Zheng H., Zuo P.L., Zhang C.X., Li W., and Zhou Z. DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release. J. Cell Biol. 181 (2008) 791-801
5. Chiba S., Hashimoto R., Hattori S., Yohda M., Lipska B., Weinberger D.R., and Kunugi H. Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus. J Neural Transm. 113 (2006) 1337-1346
6. Craddock N., O'Donovan M.C., and Owen M.J. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J. Med. Genet. 42 (2005) 193-204
7. Craig A.M., and Banker G. Neuronal polarity. Annu. Rev. Neurosci. 17 (1994) 267-310
8. Danglot L., and Galli T. What is the function of neuronal AP-3?. Biol. Cell 99 (2007) 349-361
9. Di Pietro S.M., Falcon-Perez J.M., Tenza D., Setty S.R., Marks M.S., Raposo G., and Dell'Angelica E.C. BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Mol. Biol. Cell 17 (2006) 4027-4038
10. Feng Y.Q., Zhou Z.Y., He X., Wang H., Guo X.L., Hao C.J., Guo Y., Zhen X.C., and Li W. Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia. Schizophr. Res. 106 (2008) 218-228
11. Funke B., Finn C.T., Plocik A.M., Lake S., DeRosse P., Kane J.M., Kucherlapati R., and Malhotra A.K. Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am. J. Hum. Genet. 75 (2004) 891-898
12. Harrison P.J., and Weinberger D.R. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol. Psychiatry 10 (2005) 40-68
13. Hattori S., Murotani T., Matsuzaki S., Ishizuka T., Kumamoto N., Takeda M., Tohyama M., Yamatodani A., Kunugi H., and Hashimoto R. Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Biochem. Biophys. Res. Commun. 373 (2008) 298-302
14. Igarashi M., Tagaya M., and Komiya Y. The soluble N-ethylmaleimide-sensitive factor attached protein receptor complex in growth cones: molecular aspects of the axon terminal development. J. Neurosci. 17 (1997) 1460-1470
15. Kubota K., Kumamoto N., Matsuzaki S., Hashimoto R., Hattori T., Okuda H., Takamura H., Takeda M., Katayama T., and Tohyama M. Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization. Biochem. Biophys. Res. Commun. 379 (2009) 191-195
16. Kumamoto N., Matsuzaki S., Inoue K., Hattori T., Shimizu S., Hashimoto R., Yamatodani A., Katayama T., and Tohyama M. Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin. Biochem. Biophys. Res. Commun. 345 (2006) 904-909
17. Li W., Zhang Q., Oiso N., Novak E.K., Gautam R., O'Brien E.P., Tinsley C.L., Blake D.J., Spritz R.A., Copeland N.G., Jenkins N.A., Amato D., Roe B.A., Starcevic M., Dell'Angelica E.C., Elliott R.W., Mishra V., Kingsmore S.F., Paylor R.E., and Swank R.T. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat. Genet. 35 (2003) 84-89
18. Matsuzaki S., and Tohyama M. Molecular mechanism of schizophrenia with reference to disrupted-in-schizophrenia 1 (DISC1). Neurochem. Int. 51 (2007) 165-172
19. Mouri A., Noda Y., Enomoto T., and Nabeshima T. Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment. Neurochem. Int. 51 (2007) 173-184
20. Murotani T., Ishizuka T., Hattori S., Hashimoto R., Matsuzaki S., and Yamatodani A. High dopamine turnover in the brains of sandy mice. Neurosci. Lett. 421 (2007) 47-51
21. Nakatsu F., and Ohno H. Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network. Cell Struct. Funct. 28 (2003) 419-429
22. Newell-Litwa K., Seong E., Burmeister M., and Faundez V. Neuronal and non-neuronal functions of the AP-3 sorting machinery. J. Cell Sci. 120 (2007) 531-541
23. Numakawa T., Yagasaki Y., Ishimoto T., Okada T., Suzuki T., Iwata N., Ozaki N., Taguchi T., Tatsumi M., Kamijima K., Straub R.E., Weinberger D.R., Kunugi H., and Hashimoto R. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum. Mol. Genet. 13 (2004) 2699-2708
24. Robinson M.S., and Bonifacino J.S. Adaptor-related proteins. Curr. Opin. Cell Biol. 13 (2001) 444-453
25. Salazar G., Craige B., Styers M.L., Newell-Litwa K.A., Doucette M.M., Wainer B.H., Falcon-Perez J.M., Dell'Angelica E.C., Peden A.A., Werner E., and Faundez V. BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes. Mol. Biol. Cell 17 (2006) 4014-4026
26. Scheuber A., Rudge R., Danglot L., Raposo G., Binz T., Poncer J.C., and Galli T. Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 16562-16567
27. Schwab S.G., Knapp M., Mondabon S., Hallmayer J., Borrmann-Hassenbach M., Albus M., Lerer B., Rietschel M., Trixler M., Maier W., and Wildenauer D.B. Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am. J. Hum. Genet. 72 (2003) 185-190
28. Starcevic M., and Dell'Angelica E.C. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J. Biol. Chem. 279 (2004) 28393-28401
29. Straub R.E., Jiang Y., MacLean C.J., Ma Y., Webb B.T., Myakishev M.V., Harris-Kerr C., Wormley B., Sadek H., Kadambi B., Cesare A.J., Gibberman A., Wang X., O'Neill F.A., Walsh D., and Kendler K.S. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am. J. Hum. Genet. 71 (2002) 337-348
30. Takao K., Toyama K., Nakanishi K., Hattori S., Takamura H., Takeda M., Miyakawa T., and Hashimoto R. Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol. Brain 1 (2008) 11
31. Talbot K., Eidem W.L., Tinsley C.L., Benson M.A., Thompson E.W., Smith R.J., Hahn C.G., Siegel S.J., Trojanowski J.Q., Gur R.E., Blake D.J., and Arnold S.E. Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. J. Clin. Invest. 113 (2004) 1353-1363
32. Talbot K., Cho D.S., Ong W.Y., Benson M.A., Han L.Y., Kazi H.A., Kamins J., Hahn C.G., Blake D.J., and Arnold S.E. Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin. Hum. Mol. Genet. 15 (2006) 3041-3054
33. Tang J.X., Zhou J., Fan J.B., Li X.W., Shi Y.Y., Gu N.F., Feng G.Y., Xing Y.L., Shi J.G., and He L. Family-based association study of DTNBP1 in 6p22.3 and schizophrenia. Mol. Psychiatry 8 (2003) 717-718
34. Van Den Bogaert A., Schumacher J., Schulze T.G., Otte A.C., Ohlraun S., Kovalenko S., Becker T., Freudenberg J., Jonsson E.G., Mattila-Evenden M., Sedvall G.C., Czerski P.M., Kapelski P., Hauser J., Maier W., Rietschel M., Propping P., Nothen M.M., and Cichon S. The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease. Am. J. Hum. Genet. 73 (2003) 1438-1443
35. Weickert C.S., Straub R.E., McClintock B.W., Matsumoto M., Hashimoto R., Hyde T.M., Herman M.M., Weinberger D.R., and Kleinman J.E. Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch. Gen. Psychiatry 61 (2004) 544-555