Evaluate of the efficacy and safety of tacrolimus ointment 0, 03% to treat atopic dermatitis in pediatric patients;Avaliação da eficácia e segurança do tacrolimo pomada 0, 03% no tratamento da dermatite atópica em pacientes pediátricos

Anais Brasileiros de Dermatologia

Volumn 83, Issue 6, 2008, Pages 511-519

  Gontijo, Bernardo ^a   Pires, Mario Cezar ^c   Cestari, Tania Ferreira ^e   La Scala, Cintia S Kurokawa ^f,g   Duarte, Ida A Gomes ^b   Takaoka, Roberto ^b   Aun, Wilson Tartuce ^c   De Souza, José Alexandre ^c   Cestari, Sittart Silmara Da Costa P ^d   De Oliveira, Zilda Najjar P ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c HOSPITAL DO SERVIDOR PÚBLICO ESTADUAL DE SÃO PAULO   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^e HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^f Departamento de Pediatria   (Brazil)

^g Orientadora do Curso de Pós graduação em Pediatria ^*  (United Kingdom)

Author keywords

Child; Dermatitis; Dermatitis, atopic; Eczema; Tacrolimus

Indexed keywords

TACROLIMUS;

ARTICLE; ATOPIC DERMATITIS; BODY SURFACE; BRAZIL; BURN; CHILD; CHILD CARE; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; ECZEMA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OINTMENT; PHYSICIAN; PRESCHOOL CHILD; PRURITUS; SCHOOL CHILD; TREATMENT RESPONSE; VISUAL ANALOG SCALE;

EID: 63149132043     PISSN: 03650596     EISSN: 18064841     Source Type: Journal    
DOI: 10.1590/S0365-05962008000600003     Document Type: Article

References (17)

1. Leung DY, Soter NA. Cellular and immulologic mechanisms in atopic dermatitis. J Am Acad Dermatol. 2001;44 (1 Suppl):S1-12.
2. Hanifin JM. Atopic dermatitis in infants and children. Pediatr Clin North Am. 1991;38:763-9.
3. Solé D, Camelo-Nunes IC, Waldalsen GF, Mallozi MC, Naspitz CK, Brazilian ISAAC Group. Prevalence of atopic eczema and related symptoms in Brazilian schoolchildren: results from the International Study of Asthma and Allergies in Childhood (ISAAC) phase 3. J Investig Allergol Immunol. 2006;16:367-76.
4. Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest. 2004;113:651-7.
5. Alomar A, Berth-Jones J, Bos JD, Giannetti A, Reitamo S, Ruzicka T, et al. The role of topical calcineurin inhibitors in atopic dermatitis. Br J Dermatol. 2004;151:3-27.
6. Paller A, Eichenfield LF, Leung DY, Stewart D, Appell M. A 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric patients. J Am Acad Dermatol. 2001;44(1 Suppl):S47-57.
7. Fisher DA. Adverse effects of topical corticosteroid use. West J Med. 1995;162:123-6.
8. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Dermatol Vener. 1980;92:44-7.
9. Schachner LA, Lamerson C, Sheehan MP, Boguniewicz M, Mosser J, Raimer S, et al. Tacrolimus ointment 0.03% is safe and effective for the treatment of mild to moderate atopic dermatitis in pediatric patients: results from a randomized, double-blind, vehicle-controlled study. Pediatrics. 2005;116:334-42.
10. Charman C, Williams H. Outcome measures of disease severity in atopic eczema. Arch Dermatol. 2000;136:763-9.
11. Kapp A, Allen BR, Reitamo S. Atopic dermatitis management with tacrolimus ointment (Protopic) . J Dermatol Treat. 2003;14(Suppl 1):5-16.
12. Bonifazi E, Garofalo L, Pisani V, Meneghini CL. Role of some infectious agents in atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1985;114:98-100.
13. Rystedt I, Strannegard IL, Strannegard O. Recurrent viral infections in patients with past or present atopic dermatitis. Br J Dermatol. 1986;114:575-82.
14. Fleischer AB, Ling M, Eichenfield L, Satoi Y, Jaracz E, Rico J, Maher RM. Tacrolimus ointment for the treatment of atopic dermatitis is not associated with increase in cutaneous infections. J Am Acad Dermatol. 2002;47:562-70.
15. Pournaras CC, Lubbe J, Saurat JH. Staphylococcal colonization in atopic dermatitis treatment with topical tacrolimus (Fk506). J Invest Dermatol. 2001;116:480-1.
16. Rustin MH. The safety of tacrolimus ointment for the treatment of atopic dermatitis: a review. Br J Dermatol. 2007;157:861-73.
17. Grimalt R, Mengeaud V, Cambazard F, Study Investigators' Group. The steroid-sparing effect of an emollient therapy in infants with atopic dermatitis: a randomized controlled study. Dermatology. 2007;214:61-7.