The origin of the "one cell-one antibody" rule

Journal of Immunology

Volumn 182, Issue 3, 2009, Pages 1229-1230

  Viret, Christophe ^a   Gurr, Werner ^b  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; B LYMPHOCYTE; CLONE; HUMAN; IMMUNOGLOBULIN PRODUCTION; IMMUNOREACTIVITY; MEDICAL RESEARCH; NONHUMAN; PRIORITY JOURNAL; REVIEW; THEORY; ANIMAL; BIOSYNTHESIS; CELL CLONE; CULTURE TECHNIQUE; HISTORY; IMMUNOLOGY; NOTE; SECRETION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; B-LYMPHOCYTES; CELL CULTURE TECHNIQUES; CLONE CELLS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; RECEPTORS, ANTIGEN, B-CELL;

EID: 63149128192     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.182.3.1229     Document Type: Review

References (18)

1. Silverstein, A. M. 1991. History of immunology: the dynamics of conceptual change in twentieth century immunology. Cell. Immunol. 132: 515-531.
2. Jerne, N. K. 1955. The natural-selection theory of antibody formation. Proc. Natl. Acad. Sci. USA 41: 849-857.
3. Silverstein, A. M. 1999. Paul Ehrlich's passion: the origins of his receptor immunology. Cell. Immunol. 194: 213-221.
4. Burnet, F. M. 1957. A modification of Jerne's theory of antibody production using the concept of clonal selection. Aust. J. Sci. 20: 67-68.
5. Talmage, D. W. 1957. Allergy and immunology. Annu. Rev. Med. 8: 239-257.
6. Hodgkin, P. D., W. R. Heath, and A. G. Baxter. 2007. The clonal selection theory: 50 years since the revolution. Nat. Immunol. 8: 1019-1023.
7. Ada, G. 2008. The enunciation and impact of Macfarlane Burnet's clonal selection theory of acquired immunity. Immunol. Cell Biol. 86: 116-118.
8. Nossal, G. J. V., and J. Lederberg. 1958. Antibody production by single cells. Nature 181: 1419-1420.
9. White, R. G. 1958. Antibody production by single cells. Nature 182: 1383-1384.
10. Nossal, G. J. V., and O. Makela. 1958. Kinetic studies on the incidence of cells appearing to form two antibodies. J. Immunol. 88: 604-612.
11. Nossal, G. J. V. 2002. One cell, one antibody: prelude and aftermath. Immunol. Rev. 185: 15-23.
12. Green, I., P. Vassalli, V. Nussenzweig, and B. Benacerraf. 1967. Specificity of the antibodies produced by single cells following immunisation with antigens bearing two types of antigen determinants. J. Exp. Med. 125: 511-526.
13. Attardi, G., M. Cohn, K. Horibata, and E. S. Lennox. 1959. On the analysis of antibody synthesis at the cellular level. Bacteriol. Rev. 23: 213-223.
14. Lederberg, J. 1959. Genes and antibodies. Science 129: 1649-1653.
15. Raff, M. C., M. Feldman, and S. de Petris. 1973. Monospecificity of bone marrowderived lymphocytes. J. Exp. Med. 126: 443-454.
16. Nossal, G. J. V., and B. L. Pike. 1976. Single cell studies on the antibody-forming potential of fractionated, hapten-specific B lymphocytes. Immunology 30: 189-202.
17. Köhler, G., and C. Milstein. 1975. Continuous culture of fused cells secreting antibody of predefined specificity. Nature 256: 495-496.
18. Margulies, D. H. 2005. Monoclonal antibodies: producing magic bullets by somatic cell hybridization. J. Immunol. 174: 2451-2452.