An improved method to validate the relative humidity generation in sorption balances

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 72, Issue 1, 2009, Pages 99-104

  Wadsö, Lars ^a   Anderberg, Anders ^a   Åslund, Ingrid ^a   Söderman, Olle ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Relative humidity validation; Saturated salt solutions; Sorption balance

Indexed keywords

LITHIUM CHLORIDE; MAGNESIUM CHLORIDE; MAGNESIUM NITRATE; NITRIC ACID DERIVATIVE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; WATER;

ARTICLE; DIFFUSION COEFFICIENT; HUMIDITY; ISOTHERM; MICROCALORIMETRY; MONTE CARLO METHOD; NUCLEAR MAGNETIC RESONANCE; VALIDATION PROCESS; VAPOR;

ADSORPTION; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DIFFUSION; GASES; HUMIDITY; REPRODUCIBILITY OF RESULTS; SALTS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; VOLATILIZATION;

EID: 63149122292     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.10.013     Document Type: Article

References (22)

1. Arlabosse P., Rodier E., Ferrasse J.H., Chavez S., and Lecomte D. Comparison between static and dynamic methods for sorption isotherm measurements. Drying Technnol. 21 (2003) 479-497
2. Caro Y., Pina M., Turon F., Guilbert S., Mougeot E., Fetsch D.V., Attwool P., and Graille J. Plant lipases: biocatalyst aqueous environment in relation to optimal catalytic activity in lipase-catalyzed synthesis reactions. Biotechnol. Bioeng. 77 (2002) 693-703
3. Hébrard A., Oulahna D., Galet L., Cuq B., Abecassis J., and Fages J. Hydration properties of durum wheat semolina: influence of particle size and temperature. Powder Technol. 130 (2003) 211-218
4. Robens E., Benzler B., Büchel G., Reichert H., and Schumacher K. Investigation of characterizing methods for the microstructure of cement. Cement Concrete Res. 32 (2002) 87-90
5. Williams D.R. The characterisation of powders by gravimetric water vapour sorption. Int. LABMATE 20 (1995) 40-42
6. Anderberg A., and Wadsö L. Method for simultaneous determination of the sorption isotherm and the diffusivity of cement-based materials. Cement Concrete Res. 38 (2007) 89-94
7. Levoguer C.L., and Williams D.R. The determination of permeability and diffusion rates in polymer films and packaging materials. Pharm. Technol. Europe (1997) 25-30
8. Erkselius S., Wadsö L., and Karlsson O. A sorption balance-based method to study the initial drying of dispersion droplets. Colloid Polym. Sci. 285 (2007) 1707-1712
9. Erkselius S., Wadsö L., and Karlsson O. Drying rate variations of latex dispersions due to salt induced skin formation. J. Colloid Interface Sci. 317 (2008) 83-95
10. Surface Measurement Systems Ltd., London, UK. Available from: .
11. VTI Corp., Hialeah FL, USA. Available from: .
12. Hiden Isochema Ltd., Warrington, UK. Available from: .
13. TA Instruments, New Castle DE, USA. Available from: .
14. Greenspan L. Humidity fixed points of binary saturation aqueous solutions. J. Res. NBS A 81 (1977) 89-96
15. Stilbs P. Fourier transform pulsed gradient spin echo studies of molecular diffusion. Prog. Nucl. Mag. Reson. Spectrosc. 19 (1987) 1-45
16. McNaught A.D., and Wilkinson A. Compendium of chemical terminology IUPAC recommendations. second ed. (1997), Blackwell Science, Oxford
17. Gal S. Uber die Ausdrucksweien der Konzentration des Wasserdampfes bei Wasserdampf-Sorptionsmessungen. Helvetica Chim. Acta 55 (1972) 1752-1757
18. Wadsö L., and Markova N. A method to simultaneously measure sorption isotherms and sorption enthalpies with a double twin microcalorimeter. Rev. Sci. Inst. 73 (2002) 2743-2754
19. Markova N., Sparr E., and Wadsö L. On application of an isothermal sorption microcalorimeter. Thermochim. Acta 374 (2001) 93-104
20. Wadsö L., and Markova N. Comparison of three methods to find the vapor activity of a hydration step. Eur. J. Pharm. Biopharm. 51 (2001) 81-88
21. Alper J., and Gelb R. Standard errors and confidence intervals in nonlinear regression: comparison of Monte Carlo and parametric statistics. J. Phys. Chem. 94 (1990) 4747-4751
22. 1H and less-common nuclei. J. Magn. Reson. 92 (1991) 115-125