Alkaloids from roots of Stemona sessilifolia and their antitussive activities

Planta Medica

Volumn 75, Issue 2, 2009, Pages 174-177

  Yang, Xin Zhou ^a   Zhu, Jian Yu ^b   Tang, Chun Ping ^a   Ke, Chang Qiang ^a   Lin, Ge ^c   Cheng, Tin Yan ^c   Rudd, John A ^c   Ye, Yang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHANGHAI INSTITUTE OF TECHNOLOGY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Antitussive activity; Maistemonine; Protostemonamide; Protostemonine; Stemonaceae (Stemona sessilifolia); Stemospironine

Indexed keywords

ALKALOID; ANTITUSSIVE AGENT; CITRIC ACID; MAISTEMONINE; PLANT EXTRACT; PROTOSTEMONAMIDE; PROTOSTEMONINE; STEMONA SESSILIFOLIA EXTRACT; STEMONAMINE; STEMOSPIRONINE; UNCLASSIFIED DRUG; AZEPINE DERIVATIVE; DRUG DERIVATIVE; GAMMA BUTYROLACTONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COUGHING; DRUG ISOLATION; DRUG STRUCTURE; GUINEA PIG; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT ROOT; SINGLE DRUG DOSE; STEMONA SESSILIFOLIA; STEMONACEAE; ANIMAL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DISEASE MODEL; ISOLATION AND PURIFICATION; PHYTOTHERAPY;

CAVIA; STEMONA SESSILIFOLIA; STEMONACEAE;

4-BUTYROLACTONE; ALKALOIDS; ANIMALS; ANTITUSSIVE AGENTS; AZEPINES; CITRIC ACID; COUGH; DISEASE MODELS, ANIMAL; GUINEA PIGS; MOLECULAR STRUCTURE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; STEMONACEAE;

EID: 63149109198     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0028-1088345     Document Type: Article

References (26)

1. Duyfjes BEE. Stemonaceae. In: Kalkman C, editor. Flora Malesiana Ser 1; Vol.11 Leiden: Rijksherbarium/Hortus Botanicus; 1993: 399-409
2. Tsi ZH, Duyfjes BEE. Stemonaceae. In: Wu ZY, Raven P, editors. Flora of China; Vol.24 Beijing: Science Press; 2000: 70-72
3. Greger H. Structural relationships,distribution and biological activities of Stemona alkaloids. Planta Med 2006; 72: 99-113
4. Götz M, Strunz GM. MTP international review of science. In: Wiesner K, editor. Alkaloids; Vol.9 London: Butterworth; 1973: 143-160
5. Sakata K, Aoki K, Chang CF, Sakurai A, Tamura S, Murakoshi S. Stemospironine, a new insecticidal alkaloid of Stemona japonica Miq. isolation, structural determination and activity. Agric Biol Chem 1978; 42: 457-463
6. Chung HS, Hon PM, Lin G, But PPH, Dong H. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med 2003; 69: 914-920
7. Lin LG, Zhong QX, Cheng TY, Tang CP, Ke CQ, Lin G et al. Stemoninines from the roots of Stemona tuberosa. J Nat Prod 2006; 69: 1051-1054
8. Lin LG, Li KM, Tang CP, Ke CQ, Rudd JA, Lin G et al. Antitussive stemoninine alkaloids from the roots of Stemona tuberosa. J Nat Prod 2008; 71: 1107-1110
9. Schinnerl J, Brem B, But PPH, Vajrodaya S, Hofer O, Greger H. Pyrrolo- and pyridoazepine alkaloids as chemical markers in Stemona species. Phytochemistry 2007; 68: 1417-1427
10. Irie H, Masaki N, Ohno K, Osaki K, Taga T, Uyeo S. Crystal structure of a new alkaloid, stemofoline, from Stemona japonica. J Chem Soc Chem Comm 1970; 17: 1066
11. Irie H, Ohno K, Osaki K, Taga T, Uyeo S. X-ray crystallographic determination of the structure of the alkaloid protostemonine. Chem Pharm Bull 1973; 21: 451-452
12. Ye Y, Xu RS. Studies on new alkaloids of Stemona japonica. Chin Chem Lett 1992; 3: 511-514
13. Tan GY, Zhang CF, Zhang M. Chemical constituents of the roots of wild Stemona sessilifolia. J Chin Pharm Univ 2007; 38: 499-501
14. Suzuki K. Alkaloid of Stemona japonica. J Pharm Soc Japan 1931; 51: 419-434
15. Koyama H, Oda K. Crystal and molecular structure of stemonine hydrobromide hemihydrate. J Chem Soc (B);1970: 1330-1333
16. 1H NMR line-broadening effect. Tetrahedron 1982; 38: 2667-2670
17. Kakuta D, Hitotsuyanagi Y, Matsaara N, Fukaya H, Takeya K. Structures of new alkaloids sessilifoliamides A-D from Stemona sessilifolia. Tetrahedron 2003; 59: 7779-7786
18. Hitotsuyanagi Y, Hikita M, Oda T, Kakuta D, Fukaya H, Takeya K. Structures of four new alkaloids from Stemona sessilifolia. Tetrahedron 2007; 63: 1008-1013
19. Ye Y, Qin GW, Xu RS. Alkaloids of Stemona japonica. Phytochemistry 1994; 37: 1205-1208
20. Lin WH, Zhong QX, Xu RS. Studies on new alkaloids of Stemona mairei. Chin Chem Lett 1991; 2: 369-370
21. Zou CY, Fu HZ, Lei HM, Li J, Lin WH. New alkaloids from the roots of Stemona japonica Miq. J Chin Pharm Sci 1999; 8: 185-190
22. Ye Y, Qin GW, Xu RS. Alkaloids of Stemona japonica. J Nat Prod 1994; 57: 665-669
23. Iizuka H, Irie H, Masaki N, Osaki K, Uyeo S. X-ray crystallographic determination of the structure of stemonamine, a new alkaloid from Stemona japonica Miq.: Isolation of isostemonamine. J Chem Soc (D);1973: 125-126
24. Karlsson JA, Fuller RW. Pharmacological regulation of the cough reflex - from experimental models to antitussive effects in man. Pulm Pharmacol Ther 1999; 12: 215-228
25. Belvisi MG, Bolser DC. Summary: animal models for cough. Pulm Pharmacol Ther 2002; 15: 249-250
26. 3 receptors in conscious guinea pigs. Eur J Pharmacol 1991; 209: 141-142