Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2315-2319

  Evindar, Ghotas ^a   Satz, Alexander L ^a   Bernier, Sylvie G ^a   Kavarana, Malcolm J ^a   Doyle, Elisabeth ^a   Lorusso, Jeanine ^a   Taghizadeh, Nazbeh ^a   Halley, Keith ^a   Hutchings, Amy ^a   Kelley, Michael S ^a   Wright, Albion D ^a   Saha, Ashis K ^a   Hannig, Gerhard ^a   Morgan, Barry A ^a   Westlin, William F ^a  

^a Praecis Pharmaceuticals Incorporated   (United States)

Author keywords

Arylalkoxy phenylamide; Arylalkoxy phenylimidazoles; Biarylalkoxy phenylamide; Biarylalkoxyphenylimidazoles; EDG1; FTY 720; Lymphopenia; S1P; S1P1 agonist; Sphingosine 1 phosphate

Indexed keywords

ANILIDE; FINGOLIMOD; IMIDAZOLE DERIVATIVE; PHENYLIMIDAZOLE DERIVATIVE; PPI 4667; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR SUBTYPE 1 AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTOPENIA; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; RAT;

AMIDES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; IMIDAZOLES; MICE; PROPYLENE GLYCOLS; PROTEIN SUBUNITS; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE;

RATTUS;

EID: 63149102747     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.073     Document Type: Article

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