Synthetic regulators of the 2-oxoglutarate oxidative decarboxylation alleviate the glutamate excitotoxicity in cerebellar granule neurons

Biochemical Pharmacology

Volumn 77, Issue 9, 2009, Pages 1531-1540

  Kabysheva, Maria S ^a   Storozhevykh, Tatiana P ^b   Pinelis, Vsevolod G ^b   Bunik, Victoria I ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

2 Oxoglutarate dehydrogenase; Calcium homeostasis; Glutamate excitotoxicity; Phosphono analog of 2 oxoglutarate; Tricarboxylic acid cycle

Indexed keywords

2 OXOGLUTARIC ACID; CALCIUM; ESTER DERIVATIVE; GLUTAMIC ACID; OXOGLUTARATE DEHYDROGENASE; PHOSPHONIC ACID DERIVATIVE; PHOSPHONO ETHYL ESTER; REACTIVE OXYGEN METABOLITE; SUCCINYL PHOSPHONATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CEREBELLUM; CONTROLLED STUDY; CORRELATION ANALYSIS; DECARBOXYLATION; DEREGULATION; ENCEPHALE ISOLE; ENZYME ACTIVITY; EXCITOTOXICITY; METABOLIC BALANCE; METABOLIC STRESS; MITOCHONDRION; NERVE CELL; NERVE CELL CULTURE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

ANIMALS; CALCIUM; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; KETOGLUTARATE DEHYDROGENASE COMPLEX; KETOGLUTARIC ACIDS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATION-REDUCTION; PHOSPHONIC ACIDS; RATS; RATS, WISTAR; TIME FACTORS;

EID: 63149092201     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.02.001     Document Type: Article

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