Contact-Independent cell Death of human microglial cells due to pathogenic Naegleria fowleri trophozoites

Korean Journal of Parasitology

Volumn 46, Issue 4, 2008, Pages 217-221

  Kim, Jong Hyun ^a   Kim, Daesik ^b   Shin, Ho Joon ^a  

^a Ajou University School of Medicine   (South Korea)

^b Dongnam Health University   (South Korea)

Author keywords

Cell death; Cytotoxicity; Microglial cells; Naegleria fowleri

Indexed keywords

LACTATE DEHYDROGENASE;

APOPTOSIS; ARTICLE; CELL COUNT; CELL DESTRUCTION; CELL LYSATE; CELL STRUCTURE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOPATHOLOGY; CYTOTOXICITY; FLUORESCENCE ACTIVATED CELL SORTER; HOST CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROGLIA; NAEGLERIA FOWLERI; NAEGLERIA GRUBERI; NERVE CELL NECROSIS; NONHUMAN; PARASITE VIRULENCE; PHAGOCYTOSIS; TARGET CELL; TISSUE CULTURE TECHNIQUE; TROPHOZOITE; ANIMAL; CELL LINE; CYTOLOGY; PARASITOLOGY; PHYSIOLOGY;

NAEGLERIA FOWLERI; NAEGLERIA GRUBERI;

ANIMALS; APOPTOSIS; CELL LINE; HUMANS; MICROGLIA; NAEGLERIA FOWLERI; PHAGOCYTOSIS;

EID: 63149090600     PISSN: 00234001     EISSN: 17380006     Source Type: Journal    
DOI: 10.3347/kjp.2008.46.4.217     Document Type: Article

References (23)

1. Carter RF. Description of a Naegleria species isolated from two cases of primary amoebic meningoencephalitis and of the experimental pathological changes induced by it. J Pathol 1970; 100: 217-244.
2. Schuster FL, Visvesvara GS. Free-living amebaee as opportunistic and non-opportunistic pathogens of humans and animals. Int J Parasitol 2004; 34: 1001-1027.
3. Carter RF. Primary amoebic meningoencephalitis: clinical, pathological and epidemiological features of six fatal cases. J Pathol Bacteriol 1968; 96: 1-25.
4. Anderson K, Jamieson A. Primary amoebic meningoencephalitis. Lancet 1972; 19: 379.
5. Apley J, Clarke SK, Roome AP, Sandry SA, Saygi G, Silk B, Warhurst DC. Primary amoebic meningoencephalitis in Britain. Br Med J 1970; 7: 596-599.
6. Shin HJ, Im KI. Pathogenic free-living amebaee in Korea. Korean J Parasitol 2004; 42: 93-119.
7. De Jonckheere JF. Growth characteristics, cytopathic effect in cell culture, and virulence in mice of 36 type strains belonging to 19 different Acanthamebae spp. Appl Environ Microbiol 1980; 39: 681-685.
8. Shin HJ, Cho MS, Jung SY, Kim HI, Park S, Seo JH, Yoo JC, Im KI. Cytopathic changes in rat microglial cells induced by pathogenic Acanthamebae culbertsoni: morphology and cytokine release. Clin Diagn Lab Immunol 2001; 8: 837-840.
9. Han KL, Lee HJ, Shin MH, Shin HJ, Im KI, Park SJ. The involvement of an integrin-like protein and protein kinase C in amoebic adhesion to fibronectin and amoebic cytotoxicity. Parasitol Res 2004; 94: 53-60.
10. Marciano-Cabral F, John DT. Cytopathogenicity of Naegleria fowleri for rat neuroblastoma cell cultures: scanning electron microscopy study. Infect Immun 1983; 40: 1214-1217.
11. Shin HJ, Cho MS, Jung SY, Kim HI, Park S, Kim HJ, Im KI. Molecular cloning and characterization of a gene encoding a 13.1 kDa antigenic protein of Naegleria fowleri. J Eukaryot Microbiol 2001; 48: 713-717.
12. Kang SY, Song KJ, Jeong SR, Kim JH, Park S, Kim K, Kwon MS, Shin HJ. Role of the Nfa1 protein in pathogenic Naegleria fowleri co-cultured with CHO target cells. Clin Diagn Lab Immunol 2005; 12: 873-876
13. Jeong SR, Kang SY, Lee SC, Song KJ, Im KI, Shin HJ. Decreasing effect of an anti-Nfa1 polyclonal antibody on the in vitro cytotoxicity of pathogenic Naegleria fowleri. Korean J Parasitol 2004; 42: 35-40.
14. Oh YH, Jeong SR, Kim JH, Song KJ, Kim K, Park S, Sohn S, Shin HJ. Cytopathic changes and pro-inflammatory cytokines induced by Naegleria fowleri trophozoites in rat microglial cells and protective effect of an anti-Nfa1 antibody. Parasite Immunol 2005; 27: 453-459.
15. Song KJ, Song KH, Kim JH, Sohn HJ, Lee YJ, Park CE, Shin HJ. Heat shock protein 70 of Naegleria fowleri is important factor for proliferation and in vitro cytotoxicity. Parasitol Res 2008; 103: 313-317.
16. Willaert E. Isolement et culture in vitro des amibes de genre Naegleria. Ann Soc Belg Med Trop 1971; 51: 701-708.
17. De Jonckheere JF. A group I intron in the SSUrDNA of some Naegleria spp. demonstrated by polymerase chain reaction amplification. J Euk Microbiol 1993; 40: 179-187.
18. Huston CD, Houpt ER, Mann BJ, Hahn CS, Petri WA. Caspase 3-dependent killing of host cells by the parasite Entamebae histolytica. Cell Microbiol 2000; 2: 617-625.
19. Lightowlers MW, Rickard MD. Excretory-secretory products of helminth parasites: effects on host immune responses. Parasitology 1988; 96: S123-S166.
20. Feldman MR. Naegleria fowleri: Fine structural localizaion of acid phosphatase and heme proteins. Exp Parasitol 1977; 41: 290-306.
21. Moore MB, Ubelaker JE, Marin JH, Silvany R, Dougherty JM, Meyer DR, McCulley JP. In vitro penetration of human corneal epithelium by Acanthamebae castellanii: a scanning and transmission electron microscopy study. Cornea 1991; 10: 291-298.
22. Ferrante A, Bates EJ. Elastase in the pathogenic free-living amebae Naegleria and Acanthamebae spp. Infect Immun 1988; 56: 3320-3321.
23. Khan NA, Jarrol EL, Panjwani N, Cao Z, Paget TA. Proteases as markers for differentiation of pathogenic and non-pathogenic species of Acanthamebae. J Clin Microbiol 2000; 43: 391-395.