Anticholinergic medications for managing noisy respirations in adult hospice patients

American Journal of Health-System Pharmacy

Volumn 66, Issue 5, 2009, Pages 458-464

  Kintzel, Polly E ^a,d   Chase, Sandra L ^b   Thomas, Wendy ^c   Vancamp, Diane M ^d   Clements, Elizabeth A ^d  

^a Adult Oncology   (United States)

^b Cardiolgy   (United States)

^c Adult Intensive Care   (United States)

^d SPECTRUM HEALTH   (United States)

Author keywords

Atropine; Dosage; Glycopyrrolate; Hospices; Parasympatholytic agents; Respiration disorders; Scopolamine butyl bromide; Scopolamine hydrobromide

Indexed keywords

ATROPINE; GLYCOPYRRONIUM BROMIDE; IPRATROPIUM BROMIDE; SCOPOLAMINE BROMIDE; SCOPOLAMINE BUTYL BROMIDE;

ABNORMAL RESPIRATORY SOUND; AGITATION; ARTICLE; BEDTIME DOSAGE; BLURRED VISION; CONSTIPATION; CONTINUOUS INFUSION; DELIRIUM; DISTRESS SYNDROME; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG OVERDOSE; DRUG USE; DRUG WITHDRAWAL; DRY LIP; DYING; FAMILY; FLUSHING; HALITOSIS; HALLUCINATION; HOSPICE PATIENT; HUMAN; HYPERSALIVATION; LIP DISEASE; MORNING DOSAGE; MYDRIASIS; PERSONALITY; PRIORITY JOURNAL; PSEUDOOBSTRUCTION; REPEATED DRUG DOSE; RETROSPECTIVE STUDY; SIDE EFFECT; TACHYCARDIA; TERMINALLY ILL PATIENT; THIRST; TREATMENT RESPONSE; URINARY TRACT INFECTION; URINE RETENTION; XEROSTOMIA;

EID: 63049132744     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.2146/ajhp080194     Document Type: Article

References (32)

1. Hugel H, Ellershaw J, Gambles M. Respiratory tract secretions in the dying patient: a comparison between glycopyrronium and hyoscine hydrobromide. J Palliat Care Med. 2006; 9:279-84.
2. Wildiers H, Menten J. Death rattle: prevalence, prevention and treatment. J Pain Symptom Manage. 2002; 23:310-7.
3. Morita T, Ichiki T, Tsunoda J et al. A prospective study on the dying process in terminally ill cancer patients. Am J Hosp Palliat Care. 1998; 15:217-22.
4. Multinational Association of Supportive Care in Cancer. www.mascc.org/content/444.html (accessed 2008 Mar 6).
5. Journal of Clinical Oncology. ASCO clinical guidelines. http://jco.ascopubs.org/misc/specialarticles.shtml (accessed 2008 Mar 6).
6. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology, www.nccn.org/professionals/physician-gls/default.asp (accessed 2008 Mar 6).
7. Hughes A, Wilcock A, Corcoran R et al. Audit of three antimuscarinic drugs for managing retained secretion. Palliat Med. 2000; 14:221-2.
8. Back IN, Jenkins K, Blower A et al. A study comparing hyoscine hydrobromide and glycopyrrolate in the treatment of death rattle. Palliat Med. 2001; 15:329-36.
9. Kåss RM, Ellershaw J. Respiratory tract secretions in the dying patient: a retrospective study. J Pain Symptom Manage. 2003; 26:897-902.
10. Bennett MI. Death rattle: an audit of hyoscine (scopolamine) use and review of management. J Pain Symptom Manage. 1996; 12:229-33.
11. Bachrach SJ, Walter RS, Trzcinski K. Use of glycopyrrolate and other anticholinergic medications for sialorrhea in children with cerebral palsy. Clin Pediatr. 1998;37:485-90.
12. Mier RJ, Bachrach SJ, Lakin RC et al. Treatment of sialorrhea with glycopyrrolate. Arch Pediatr Adolesc Med. 2000;154:1214-8.
13. Stern LM. Preliminary study of glycopyrrolate in the management of drooling. J Paediatr Child Health. 1997; 33:52-4.
14. Rashid H, Long JD, Wadleigh RG. Management of secretions in esophageal cancer patients with glycopyrrolate. Ann Oncol. 1997; 8:198-9.
15. Talmi YP, Finkelstein Y, Zohar Y. Reduction of salivary flow with transdermal scopolamine: a four year experience. Otolaryngol Head Neck Surg. 1990; 103:615-8.
16. Hyson HC, Johnson AM, log MS. Sublingual atropine for sialorrhea secondary to parkinsonism: a pilot study. Mov Disord. 2002; 17:1318-20.
17. Tessier P, Antonello C. Clozapine and sialorrhea. J Psychiatry Neurosci. 2001;26:253. Letter.
18. Freudenreich O, Beebe M, Goff DC. Clozapine-induced sialorrhea treated with sublingual ipratropium spray: a case series. J Clin Psychopharmacol. 2004;24:98-100. Letter.
19. Olsen AK, Sjøgren P. Oral glycopyrrolate alleviates drooling in a patient with tongue cancer. J Pain Symptom Manage. 1999; 18:300-2.
20. Duggal HS. Glycopyrrolate for clozapine-induced sialorrhea. Prog Neuropsycho-pharmacol Biol Psychiatry. 2007; 31:1546-7. Letter.
21. Tassinari D, Poggi B, Fantini M et al. Treating sialorrhea with transdermal scopolamine. Exploiting a side effect to treat an uncommon symptom in cancer patients. Support Care Cancer. 2005;13:559-61.
22. Antonello C, Tessier P. Clozapine and sialorrhea: a new intervention for this bothersome and potentially dangerous side effect. J Psychiatry Neurosci. 1999;24:250. Letter.
23. Sharma A, Ramaswamy S, Dahl E et al. Intraoral application of atropine sulfate ophthalmic solution for clozapine-induced sialorrhea. Ann Pharmacotherapy. 2004; 38:1538. Letter.
24. Hallenbeck I. Palliative care in the final days of Me. JAMA. 2005; 293:2265-71.
25. Transderm Scop (scopolamine 1.5 mg). Travel Patch. Prescribing information. www.transdermscop.com/infomed-prescribing.htm (accessed 2008 Mar 6).
26. Nachum Z, Shupak A, Gordon CR. Transdermal scopolamine for prevention of motion sickness: clinical pharmacokinetics and therapeutic applications. Clin Pharmacokinet. 2006; 45:543-66.
27. Kantu J, Klotz U. Pharmacokinetic implications for the clinical use of atropine, scopolamine and glycopyrrolate. Acta Anaesthesiol Scand. 1988; 32:69-78.
28. Desalu I, Kushimo OT, Bode CO. A comparative study of the haemodynamic effects of atropine and glycopyrrolate at induction of anaesthesia in children. West Afr J Med. 2005; 24:115-9.
29. Mirakhur RK. Intravenous administration of glycopyrronium: effects on cardiac rate and rhythm. Anaesthesia. 1979; 34:458-62.
30. Morgensen F, Müller D, Valentin N. Glycopyrrolate during ketamine/diazepam anesthesia. A double-blind comparison with atropine. Acta Anaesthesiol Scand. 1986; 30:332-6.
31. Toft P, Rømer UD. Glycopyrrolate compared with atropine in association with ketamine anaesthesia. Acta Anaesthesiol Scand. 1987;31:438-40.
32. Brown JH, Taylor P. Muscarinic receptor agonists and antagonists. In: Brunten LL, Lazo JS, Parker KL, eds. Goodman 8 Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York: McGraw-Hill Medical Publishing Division; 2006:183-200.