Non-neutralizing anti-FVIII antibodies: Different binding specificity to different recombinant FVIII concentrates

Haemophilia

Volumn 15, Issue 1, 2009, Pages 374-376

  Vincent, A M ^a   Lillicrap, D ^b   Boulanger, A ^a   Meilleur, C ^a   Amesse, C ^a   St louis, J ^c   Rivard, Georges E ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

^c MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8 ANTIBODY; BLOOD CLOTTING FACTOR 8 INHIBITOR; RECOMBINANT BLOOD CLOTTING FACTOR 8;

ADULT; AGED; ANTIBODY DETECTION; ANTIBODY TITER; ANTIGEN BINDING; ARTICLE; BLOOD CLOTTING TEST; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMOPHILIA A; HUMAN; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; SIDE EFFECT;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODY SPECIFICITY; FACTOR VIII; FEMALE; HEMOPHILIA A; HUMANS; ISOANTIBODIES; MALE; MIDDLE AGED; RECOMBINANT PROTEINS;

EID: 63049114320     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/j.1365-2516.2008.01909.x     Document Type: Article

References (5)

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2. Towfighi F, Gharagozlou S, Sharifian RA et al. Comparative measurement of anti-factor VIII antibody by Bethesda assay and ELISA reveals restrictive isotype profile and epitope specificity. Acta Haematol 2005; 114: 84-90.
3. Sahud MA, Pratt KP, Zhukov O, Qu K, Thompson AR. ELISA system for detection of immune response to FVIII: A study of 246 samples and correlation with the Bethesda assay. Haemophilia 2007; 13: 317-22.
4. Ling M, Duncan EM, Rodgers SE, Street AM, Lloyd JV. Low detection rate of antibodies to non-functional epitopes of factor VIII in patients with hemophilia A and negative for inhibitors by Bethesda assay. J Thromb Haemost 2003; 1: 2548-53.
5. Astermark J, Voorberg J, Lenk H et al. Impact of inhibitor epitope profile on the neutralizing effect against plasma-derived and recombinant factor VIII concentrates in vitro. Haemophilia 2003; 9: 567-72.