Retinal flavoprotein autofluorescence as a measure of retinal health

Transactions of the American Ophthalmological Society

Volumn 106, Issue , 2008, Pages 215-222

  Elner, Susan G ^a   Elner, Victor M ^a   Field, Matthew G ^a   Park, Seung ^a   Heckenlively, John R ^a   Petty, Howard R ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLAVOPROTEIN; RETINAL FLAVOPROTEIN; UNCLASSIFIED DRUG; ACETYLCYSTEINE; ANTIOXIDANT; CERAMIDE; DIHYDROCERAMIDE; DRUG DERIVATIVE; FLAVINE ADENINE NUCLEOTIDE; HYDROGEN PEROXIDE; N ACETYLSPHINGOSINE; N-ACETYLSPHINGOSINE; SPHINGOSINE;

ADULT; AGED; ARTICLE; AUTOFLUORESCENCE; CENTRAL SEROUS RETINOPATHY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC RETINOPATHY; EYE CARE; HUMAN; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA DYSTROPHY; RETINA MACULA AGE RELATED DEGENERATION; APOPTOSIS; CELL CULTURE; DRUG EFFECT; FLUORESCENCE; METABOLISM; MIDDLE AGED; MITOCHONDRION; PHOTOGRAPHY; RETINA; RETINA DISEASE;

ACETYLCYSTEINE; ADULT; AGED; ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; CERAMIDES; FLAVIN-ADENINE DINUCLEOTIDE; FLUORESCENCE; HUMANS; HYDROGEN PEROXIDE; MIDDLE AGED; MITOCHONDRIA; PHOTOGRAPHY; RETINA; RETINAL DISEASES; RETINAL PIGMENT EPITHELIUM; SPHINGOSINE;

EID: 63049086686     PISSN: None     EISSN: 15456110     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Martinou JC, Green DR. Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 2001;2:63-67.
2. Lemasters JJ. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol 2006;22:S31-S37.
3. Du Y, Miller CM, Kern TS. Hyperglycemia increases mitochondrial superoxide in retina and retinal cells. Free Rad Biol Med 2003;35:1491-1499.
4. Ning X, Baoyu Q, Yuzhen L, Shuli S, Reed E, Li QQ. Neuro-optic cell apoptosis and microangiopathy in KKAY mouse retina. Int J Mol Med 2004;13:87-92.
5. Benson RC, Meyer RA, Zaruba ME, McKhann GM. Cellular autofluorescence-is it due to flavins? J Histochem Cytochem 1979;27:44-48.
6. Kindzelskii A, Petty HR. Fluorescence spectroscopic detection of mitochondrial flavoprotein redox oscillations and transient reduction of the NADPH oxidase-associated flavoprotein in leukocytes. Eur Biophys J 2004;33:291-299.
7. Reinert KC, Dunbar RL, Wangcai G, Gang C, Ebner TJ. Flavoprotein autofluorescence imaging of neuronal activation in the cerebellar cortex in vivo. J Neurophysiol 2004;92:199-211.
8. Kuznetsov AV, Mayboroda O, Kunz D, Winkler K, Schubert W, Kunz WS. Functional imaging of mitochondria in saponinpermeabilized mice muscle fibers. J Cell Biol 1998;140:1091-1099.
9. Kunz WS. Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis. J Neurol Sci 1998;156:65-72.
10. Kunz D, Luley C, Winkler K, Lins H, Kunz WS. Flow cytometric detection of mitochondrial dysfunction in subpopulations of human mononuclear cells. Anal Biochem 1997;246:218-224.
11. Kunz WS, Gellerick FN. Quantification of the content of fluorescent flavoproteins in mitochondria from liver, kidney, cortex, skeletal muscle, and brain. Biochem Med Metabol Biol 1993;50:103-110.
12. Romashko DN, Marban E, O'Rourke B. Subcellular metabolic transients and mitochondrial redox waves in heart muscle. Proc Natl Acad Sci U S A 1998;95:1618-1623.
13. Wallace DC. Diseases of the mitochondrial DNA. Ann Rev Biochem 1992:61:1175-1212.
14. Morgan-Hughes JA. Mitochondrial diseases of muscle. Curr Opin Neurol 1994:7:457-462.
15. Koke JR, Wylie W, Wills M. Sensitivity of flavoprotein fluorescence to oxidative state in single isolated heart cells. Cytobios 1981;32:139-145.
16. Shino A, Matsuda M, Handa J, Chance B. Poor recovery of mitochondrial redox state in CA1 after transient forebrain ischemia in gerbils. Stroke 1998;29:2421-2425.
17. Ranji M, Kanemoto S, Matsubara M, et al. Fluorescence spectroscopy and imaging of myocardial apoptosis. J Biomed Optics 2006;11:064036-1-064036- 4.
18. Rajpurohit R, Mansfield K, Ohyama K, Ewert D, Shapiro IM. Chondrocyte death is linked to development of a mitochondrial membrane permeability transition in the growth plate. J Cell Physiol 1999;179:287-296.
19. Winkler K, Kuznetsov AV, Lins H, et al. Laser-excited fluorescence studies of mitochondrial function in saponin-skinned skeletal muscle fibers of patients with chronic progressive external ophthalmolplegia. Biochim Biophys Acta 1995;1272:181-184.
20. Elner VM, Park S, Cornblath W, Hackel R, Petty HR. Flavoprotein autofluorescence detection of early ocular dysfunction. Arch Ophthalmol 2008;126:259-260.
21. Field MG, Elner VM, Puro DG, et al. Rapid, noninvasive detection of diabetes-induced retinal metabolic stress. Arch Ophthalmol 2008;126:934-938.
22. Elner SG, Strieter RM, Elner VM, Rollins BJ, Del Monte MA, Kunkel SL. Monocyte chemotactic protein gene expression by cytokine-treated human retinal pigment epithelial cells. Lab Invest 1991;64:819-825.
23. Yang D, Elner SG, Bian Z-M, Till GO, Petty HR, Elner VM. Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 2007;85:462-472.
24. Jin GF, Hurst JS, Godley BF. Hydrogen peroxide stimulates apoptosis in cultured human retinal pigment epithelial cells. Curr Eye Res 2001;22:165-173.
25. Barak A, Morse LS, Goldkorn T. Ceramide: a potential mediator of apoptosis in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2001;42:247-254.
26. Chance B, Salkovitz IA, Kovach AG. Kinetics of mitochondrial flavoprotein and pyridine nucleotide in perfused heart. Am J Physiol 1972;223:207-218.
27. Kowluru RA, Abbas SN. Diabetes-induced mitochondrial dysfunction in the retina. Invest Ophthalmol Vis Sci 2003;44:5327-5334.
28. Lin J, Bierhaus A, Bugert P, et al. Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy. Diabetologia 2006;49:1089-1096.
29. Duchen MR. Section III: Mitochondria, β-cell function and type 2 diabetes. Diabetes 2004;53:S96-S102.
30. Hammer M, Konigsdorffer E, Lieberman C, et al. Ocular fundus auto-fluorescence observations at different wavelengths in patients with age-related macular degeneration and diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2008;246:105-114.
31. Gopalkrishnapillai B, Nadanathangam V, Karmakar N, Anand S, Misra A. Evaluation of autofluorescent property of hemoglobin-advanced glycation end product as a long-term glycemic index of diabetes. Diabetes 2003;52:1041-1046.