Experiences with HUS in Canada: What have we learned about childhood HUS in Canada?

Kidney International

Volumn 75, Issue SUPPL. 112, 2009, Pages

  McLaine, Peter N ^a,d   Rowe, Peter C ^b   Orrbine, Elaine ^c  

^a CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^b JOHNS HOPKINS CHILDREN S CENTER   (United States)

^c Canadian Association of Paediatric Health Centres   (Canada)

^d NONE   (Canada)

Author keywords

Clinical features; Hemolytic uremic syndrome; Renal prognosis; Risk factors for VTEC HUS; Synsorb; Verotoxin

Indexed keywords

ANTIBIOTIC AGENT; ANTIDIARRHEAL AGENT; CHEMOSORB; ERYTHROCYTE ANTIGEN; IOTALAMIC ACID; SILICON DIOXIDE; SYNSORB PK; TRISACCHARIDE; UNCLASSIFIED DRUG; VEROTOXIN 2; ORGANOSILICON DERIVATIVE; SHIGA TOXIN;

ACADEMIC ACHIEVEMENT; ANTIBODY PRODUCING CELL; APPLE JUICE; BACTERIAL TRANSMISSION; BEHAVIOR DISORDER; BLOODY DIARRHEA; CANADA; CHEMOPROPHYLAXIS; CHILD; CHILDHOOD DISEASE; CLINICAL TRIAL; COGNITIVE DEFECT; CONFERENCE PAPER; CONTINUOUS INFUSION; CONTROLLED STUDY; DIALYSIS; DRUG EFFICACY; DRUG SAFETY; ESCHERICHIA COLI O157; GASTROENTERITIS; GLOMERULUS FILTRATION RATE; HEMATURIA; HEMOLYTIC ANEMIA; HEMOLYTIC UREMIC SYNDROME; HUMAN; INCIDENCE; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; LEUKOCYTE COUNT; MEAT; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; SEX RATIO; SHIGA TOXIN PRODUCING ESCHERICHIA COLI; ADOLESCENT; CHRONIC KIDNEY FAILURE; DATA BASE; ESCHERICHIA COLI INFECTION; METABOLISM; MICROBIOLOGY; ONSET AGE; PATHOGENICITY; PRESCHOOL CHILD; PROGRAM DEVELOPMENT; RENAL REPLACEMENT THERAPY; REVIEW; TREATMENT OUTCOME;

ADOLESCENT; AGE OF ONSET; CANADA; CHILD; CHILD, PRESCHOOL; DATABASES AS TOPIC; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI O157; HEMOLYTIC-UREMIC SYNDROME; HUMANS; KIDNEY FAILURE, CHRONIC; ORGANOSILICON COMPOUNDS; PROGRAM DEVELOPMENT; RENAL DIALYSIS; RISK FACTORS; SHIGA TOXINS; TREATMENT OUTCOME; TRISACCHARIDES;

EID: 63049084243     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.614     Document Type: Conference Paper

References (40)

1. McLaine PN, Orrbine E. Can Ped Kid Disease Research Centre. Ann RCPSC 1989; 22: 531-532.
2. McLaine PN. Hemolytic uremic syndrome: events of the past decade. Paediatr Child Health 2002; 7: 533-537.
3. Karmali MA, Petric M, Steele BT et al. Sporadic cases of haemolytic-uremic syndrome associated with faecal cytotoxin-producing Escherichia coli in stools. Lancet 1983; 1: 619-620.
4. Borczyk AA, Karmali MA, Lior H et al. Bovine reservoir for verotoxin-producing Escherichia coli 0157:H7. Lancet 1987; 1: 98.
5. Riley LW, Remis RS, Helgerson SD et al. Hemorrhagic colitis associated with a rare Escherichia coli serotype. N Engl J Med 1983; 308: 681-685.
6. Griffin PM, Ostroff SM, Tauxe RV et al. Illnesses associated with Escherichia coli 0157:H7 infections: a broad clinical spectrum. Ann Intern Med 1988; 109: 705-712.
7. Steele BT, Murphy N, Arbus GS et al. An outbreak of hemolytic uremic syndrome associated with ingestion of fresh apple juice. J Pediatr 1982; 101: 963-965.
8. Spika JS, Parsons JE, Nordenberg D et al. Hemolytic-uremic syndrome and diarrhea associated with Escherichia coli 0157:H7 in a day care centre. J Pediatr 1986; 109: 287-291.
9. Rowe PC, Orrbine E, Lior H et al. Diarrhoea in close contacts as a risk factor for childhood haemolytic uraemic syndrome. Epidemiol Infect 1993; 110: 9-16.
10. Swerdlow DL, Woodruff BA, Brady RC et al. A waterborne outbreak in Missouri of Escherichia coli 0157:H7 associated with bloody diarrhea and death. Ann Intern Med 1992; 117: 812-819.
11. Ackers M, Mahon BE, Leahy E et al. An outbreak of Escherichia coli 0157:H7 infections associated with leaf lettuce consumption. J Infect Dis 1998; 177: 1588-1593.
12. Rowe PC, Orrbine E, Wells GA et al. Canadian Pediatric Kidney Disease Research Centre. Epidemiology of hemolytic uremic syndrome in Canadian children from 1986 to 1988. J Pediatr 1991; 119: 218-224.
13. Cimolai N, Carter JE, Morrison BJ et al. Risk factors for the progression of Escherichia coli 0157:H7 enteritis to hemolytic uremic syndrome. J Pediatr 1990; 116: 589-592.
14. Walterspiel JN, Ashkenazi S, Morrow AL et al. Effect of subinhibitory concentrations of antibiotics on extracellular Shiga-like toxin I. Infection 1992; 20: 25-29.
15. Wong CS. The risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli 0157:H7 infections. N Engl J Med 2000; 324: 1930.
16. Scotland SM, Willishaw GA, Smith HR et al. Properties of strains of Escherichia coli belonging to serogroup 0157 with special reference to production of Vero cytotoxins VT1 and VT2. Epidemiol Infect 1987; 99: 613-624.
17. Ostroff SM, Tarr PI, Neill MA et al. Toxin genotypes and plasmid profiles as determinants of systemic sequelae in Escherichia coli 0157:H7 infections. J Infect Dis 1989; 160: 994-998.
18. Pavia AT, Nicols CR, Green DP et al. Hemolytic uremic syndrome during an outbreak of Escherichia coli 0157:H7 infections in institutions for mentally retarded persons: clinical and epidemiologic observations. J Pediatr 1990; 116: 544-551.
19. Taylor CM, Milford DV, Rose PE et al. The expression of blood group P1 in post-enteropathic haemolytic uraemic syndrome. Pediatr Nephrol 1990; 4: 59-61.
20. Rowe PC, Orrbine E, Lior H et al., the CPKDRC Co-investigators. Diarrhoea in close contacts as a risk factor for childhood haemolytic uraemic syndrome. Epidemiol Infect 1993; 110: 9-16.
21. Rowe PC, Orrbine E, Lior H et al., the CPKDRC Co-investigators. A prospective study of exposure to verotoxin-producing Escherichia coli among children with haemolytic uraemic syndrome. Epidemiol Infect 1993; 110: 1-7.
22. Carter AO, Borczyk AA, Carlson JAK et al. A severe outbreak of E. coli 0157:H7-associated hemorrhagic colitis in a nursing home. N Engl J Med 1987; 317: 1496-1500.
23. Karmali MA, Arbus GS, Petric M et al. Hospital-acquired Escherichia coli 0157:H7 associated haemolytic uraemic syndrome in a nurse. Lancet 1988; 1: 576.
24. Spika JS, Parsons JE, Nordenberg D et al. Hemolytic uremic syndrome and diarrhea associated with Escherichia coli 0157:H7 in a day care center. J Pediatr 1986; 109: 287-291.
25. Karmali MA, Arbus GS, Ish-Shalom N et al. A family outbreak of hemolytic uremic syndrome associated with verotoxin-producing Escherichia coli serotype 0157:H7. Pediatr Nephrol 1988; 1: 409-414.
26. Rowe PC, Orrbine E, Lior H et al., The Investigators of the Canadian Pediatric Disease Kidney Research Centre. Risk of hemolytic uremic syndrome after sporadic Escherichia coli 0157:H7 infection: results of a Canadian collaborative study. J Pediatr 1988; 132: 777-782.
27. Schlieper A, Orrbine E, Wells GA, et al., for the Investigators of the HUS Cognitive Study. Neuropsychological sequelae of haemolytic uraemic syndrome. Arch Dis Child 1999; 80: 214-220.
28. Trompeter R, Schwartz R, Chantler C et al. Haemolytic-uraemic syndrome: an analysis of prognostic features. Arch Dis Child 1983; 58: 101-105.
29. Loirat C, Sonsino E, Varga Moreno A et al. Hemolytic-uremic syndrome: an analysis of the natural history and prognostic features. Acta Paediatr Scand 1984; 73: 505-514.
30. O'Regan S, Blais N, Rousseau P et al. Hemolytic uremic syndrome: glomerular filtration rate, 6 to 11 years later measured by 99mTc DTPA plasma slope clearance. Clin Nephrol 1989; 32: 217-220.
31. Fitzpatrick MM, Shah V, Trompeter RS et al. Long term renal outcome of childhood haemolytic uraemic syndrome. BMJ 1991; 303: 489-492.
32. Gagnadoux MF, Habib R, Gubler MC et al. Long-term (15-20 years) outcome of childhood hemolytic-uremic syndrome. Clin Nephrol 1996; 46: 39-41.
33. Siegler RL, Milligan MK, Burningham TH et al. Long-term outcome and prognostic indicators in the hemolytic-uremic syndrome. J Pediatr 1991; 118: 195-200.
34. Siegler RL, Pavia AT, Christofferson RD et al. A 20-year population-based study of postdiarrheal hemolytic-syndrome in Utah. Pediatrics 1994; 94: 35-42.
35. Ogborn MR, Hamiwka L, Orrbine E et al. Renal function in Inuit survivors of epidemic hemolytic-uremic syndrome. Pediatr Nephrol 1998; 12: 485-488.
36. Armstrong GD, Fodor E, Vanmaele R. Investigation of Shiga-like toxin binding to chemically synthesized oligosaccharide sequences. J Infect Dis 1991; 164: 1160-1167.
37. Armstrong GD, Rowe PC, Goodyear P et al. A phase I study of chemically synthesized Verotoxin (Shiga-like toxin) Pk-trisaccharide receptors attached to Chromosorb for preventing hemolytic-uremic syndrome. J Infect Dis 1995; 171: 1042-1045.
38. Armstrong GD, McLaine PN, Rowe PC. Clinical trials of Synsorb-Pk in preventing hemolytic-uremic syndrome. In: Kaper JB, O'Brien AD (eds). Escherichia coli Strains. American Society for Microbiology: Washington, DC, 1998, pp 374-384.
39. Hüsemann M, Gellermann J, Volloner I et al. Long-term prognosis of hemolytic-uremic syndrome and effective renal plasma flow. Pediatr Nephrol 1999; 13: 672-677.
40. Garg AX, Suri RS, Barrowman N et al. Long-term prognosis of diarrhea-associated hemolytic-uremic syndrome: a systematic review, meta-analysis and meta-regression. JAMA 2003; 290: 1379-1381.