Genomewide linkage in a large caucasian family maps a new locus for intracranial aneurysms to chromosome 13q

Stroke

Volumn 40, Issue 3 SUPPL. 1, 2009, Pages

  Santiago Sim, Teresa ^a   Depalma, Steven R ^a   Ju, Kevin L ^a   McDonough, Barbara ^a   Seidman, Christine E ^a,b   Seidman, J G ^a   Kim, Dong H ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Genetics; Intracranial aneurysm; Linkage

Indexed keywords

ADULT; AGED; BRAIN ANGIOGRAPHY; BRAIN ARTERY ANEURYSM; CAUCASIAN; CHROMOSOME 13Q; CLINICAL ARTICLE; CONFERENCE PAPER; FAMILY STUDY; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENOME; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; PEDIGREE ANALYSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; CHROMOSOMES, HUMAN, PAIR 13; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTRACRANIAL ANEURYSM; LINKAGE (GENETICS); MALE; MIDDLE AGED; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 62949201039     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.108.534396     Document Type: Conference Paper

References (15)

1. Kim DH, Van Ginhoven G, Milewicz DM. Incidence of familial intracranial aneurysms in 200 patients: comparison among Caucasian, African-American, and Hispanic populations. Neurosurgery. 2003;53:302-308.
2. Wills S, Ronkainen A, van der Voet M, Kuivaniemi H, Helin K, Leinonen E, Frosen J, Niemela M, Jaaskelainen J, Hernesniemi J, Tromp G. Familial intracranial aneurysms: an analysis of 346 multiplex Finnish families. Stroke. 2003;34:1370-1374.
3. Kojima M, Nagasawa S, Lee YE, Takeichi Y, Tsuda E, Mabuchi N. Asymptomatic familial cerebral aneurysms. Neurosurgery. 1998;43:776-781.
4. Bromberg JE, Kinkel GJ, Algra A, Greebe P, van Duyn CM, Hasan D, Limburg M, ter Berg HW, Wijdicks EF, van Gijn J. Subarachnoid haemorrhage in first and second degree relatives of patients with subarachnoid haemorrhage. BMJ. 1995;311:288-289.
5. Onda H, Kasuya H, Yoneyama T, Takakura K, Hori T, Takeda J. Nakajima T, Inoue I. Genomewide-linkage and haplotype-association studies map intracranial aneurysm to chromosome 7q 11. Am J Hum Genet. 2001;69:804-819.
6. van der Voet M, Olson JM, Kuivaniemi H, Dudek DM, Skunca M, Ronkainen A, Niemela M, Jaaskelainen J, Hernesniemi J, Helin K. Leinonen E, Biswas M, Tromp G. Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3. Am J Hum Genet. 2004;74:564-571.
7. Yamada S, Utsunomiya M, Inoue K, Nozaki K, Inoue S, Takenaka K, Hashimoto N. Koizumi A. Genome-wide scan for Japanese familial intracranial aneurysms: linkage to several chromosomal regions. Circulation. 2004;110:3727-3733.
8. Ozturk AK, Nahed BV, Bydon M, Bilguvar K, Goksu E, Bademci G, Guclu B, Johnson MH, Amar A, Lifton RP, Gunel M. Molecular genetic analysis of two large kindreds with intracranial aneurysms demonstrates linkage to 11q24-25 and 14q23-31. Stroke. 2006;37:1021-1027.
9. Farnham JM, Camp NJ, Neuhausen SL, Tsuruda J, Parker D, MacDonald J, Cannon-Albright LA. Confirmation of chromosome 7q11 locus for predisposition to intracranial aneurysm. Hum Genet. 2004;114:250-255.
10. Krischek B, Narita A, Akagawa H, Kasuya H, Tajima A, Onda H, Yoneyama T, Hori T, Inoue I. Is there any evidence for linkage on chromosome 17cen in affected Japanese sib-pairs with an intracranial aneurysm? J Hum Genet. 2006;51:491-494.
11. Nahed BV, Seker A. Guclu B, Ozturk AK, Finberg K, Hawkins AA, DiLuna ML, State M, Lifton RP, Gunel M. Mapping a mendelian form of intracranial aneurysm to 1p34.3-p36.13. Am J Hum Genet. 2005;76: 172-179.
12. Roos YB, Pals G, Struycken PM, Rinkel GJ. Limburg M, Pronk JC, van den Berg JS, Luijten JA, Pearson PL, Vermeulen M, Westerveld A. Genome-wide linkage in a large Dutch consanguineous family maps a locus for intracranial aneurysms to chromosome 2p13. Stroke. 2004;35: 2276-2281.
13. Verlaan DJ, Dube MP, St-Onge J, Noreau A, Roussel J, Satge N, Wallace MC, Rouleau GA. A new locus for autosomal dominant intracranial aneurysm, anib4, maps to chromosome 5pl5.2-14.3. J Med Genet. 2006; 43:e31.
14. Mineharu Y, Inoue K, Inoue S, Yamada S, Nozaki K, Hashimoto N, Koizumi A. Model-based linkage analyses confirm chromosome 19q13.3 as a susceptibility locus for intracranial aneurysm. Stroke. 2007;38: 1174-1178.
15. Foroud T, Sauerbeck L, Brown R, Anderson C, Woo D, Kleindorfer D, Flaherty ML, Deka R, Hornung R, Meissner I, Bailey-Wilson JE, Rouleau G, Connolly ES, Lai D, Koller DL, Huston J III, Broderick JP. Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study. Stroke. 2008;39:1434-1440.