The response to lenalidomide of myelodysplastic syndrome patients with deletion del(5q) can be sequentially monitored in CD34+ progenitor cells

Haematologica

Volumn 94, Issue 3, 2009, Pages 430-431

  Mohr, Brigitte ^a   Oelschlaegel, Uta ^a   Thiede, Christian ^a   Stewart, Michelle Meredyth ^a   Ehninger, Gerhard ^a   Platzbecker, Uwe ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

CD34+; Deletion 5q; Lenalidomide; Myelodysplastic syndrome

Indexed keywords

CD34 ANTIGEN; LENALIDOMIDE;

CHROMOSOME 5Q; CHROMOSOME DELETION; ERYTHROCYTE TRANSFUSION; HUMAN; LETTER; MYELODYSPLASTIC SYNDROME; STEM CELL;

AGED; ANTIGENS, CD34; ANTINEOPLASTIC AGENTS; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 5; CYTOGENETIC ANALYSIS; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; THALIDOMIDE; TREATMENT OUTCOME;

EID: 62949169179     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.13865     Document Type: Letter

References (5)

1. Cazzola M. Myelodysplastic syndrome with isolated 5q deletion (5q- syndrome). A clonal stem cell disorder characterized by defective ribosome biogenesis. Haematologica 2008;93:967-72.
2. List A, Kurtin S, Roe DJ, Buresh A, Mahadevan D, Fuchs D, et al. Efficacy of Lenalidomide in Myelodysplastic Syndromes. N Engl J Med 2005;352:549-57.
3. List A, Dewald G, Bennett J, Giagounidis A, Raza A, Feldman E, et al. Lenalidomide in the Myelodysplastic Syndrome with Chromosome 5q Deletion. N Engl J Med 2006;355:1456-65.
4. Mattsson J, Uzunel M, Tammik L, Aschan J, Ringdén O. Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after allogeneic stem cell transplantation. Leukemia 2001;15:1976-85.
5. Thiede C, Lutterbeck K, Oelschlägel U, Kiehl M, Steudel Ch, Platzbecker U, et al. Detection of relapse by sequential monitoring of chimerism in circulating CD34+ cells. Ann Hematol 2002;81(Suppl 2):S27-8.