메뉴 건너뛰기




Volumn 30, Issue 4, 2009, Pages 188-193

Polymorphisms determine β-adrenoceptor conformation: implications for cardiovascular disease and therapy

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CARVEDILOL;

EID: 62949132260     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2009.02.001     Document Type: Article
Times cited : (11)

References (66)
  • 1
    • 0032707530 scopus 로고    scopus 로고
    • Adrenergic and muscarinic receptors in the human heart
    • Brodde O.E., and Michel M.C. Adrenergic and muscarinic receptors in the human heart. Pharmacol. Rev. 51 (1999) 651-690
    • (1999) Pharmacol. Rev. , vol.51 , pp. 651-690
    • Brodde, O.E.1    Michel, M.C.2
  • 2
    • 0242637601 scopus 로고    scopus 로고
    • What is the role of β-adrenergic signaling in heart failure?
    • Lohse M.J., et al. What is the role of β-adrenergic signaling in heart failure?. Circ. Res. 93 (2003) 896-906
    • (2003) Circ. Res. , vol.93 , pp. 896-906
    • Lohse, M.J.1
  • 3
    • 33744900324 scopus 로고    scopus 로고
    • 1- and β-adrenoceptor signaling in the heart
    • 1- and β-adrenoceptor signaling in the heart. Trends Pharmacol. Sci. 27 (2006) 330-337
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 330-337
    • Xiao, R.P.1
  • 4
    • 0033550817 scopus 로고    scopus 로고
    • 1-adrenoceptor: identification and rapid screening assay
    • 1-adrenoceptor: identification and rapid screening assay. Lancet 353 (1999) 897
    • (1999) Lancet , vol.353 , pp. 897
    • Maqbool, A.1
  • 5
    • 0033730995 scopus 로고    scopus 로고
    • 1-adrenergic receptor associated with survival in patients with heart failure
    • 1-adrenergic receptor associated with survival in patients with heart failure. Eur. Heart J. 21 (2000) 1853-1858
    • (2000) Eur. Heart J. , vol.21 , pp. 1853-1858
    • Borjesson, M.1
  • 6
    • 0033136976 scopus 로고    scopus 로고
    • 1-adrenoceptor gene and evaluation of its role in idiopathic dilated cardiomyopathy. CARDIGENE Group
    • 1-adrenoceptor gene and evaluation of its role in idiopathic dilated cardiomyopathy. CARDIGENE Group. J. Mol. Cell. Cardiol. 31 (1999) 1025-1032
    • (1999) J. Mol. Cell. Cardiol. , vol.31 , pp. 1025-1032
    • Tesson, F.1
  • 7
    • 0033617342 scopus 로고    scopus 로고
    • 1-adrenergic receptor
    • 1-adrenergic receptor. J. Biol. Chem. 274 (1999) 12670-12674
    • (1999) J. Biol. Chem. , vol.274 , pp. 12670-12674
    • Mason, D.A.1
  • 8
    • 0037163005 scopus 로고    scopus 로고
    • 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation
    • 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation. J. Biol. Chem. 277 (2002) 30429-30435
    • (2002) J. Biol. Chem. , vol.277 , pp. 30429-30435
    • Levin, M.C.1
  • 9
    • 0036146859 scopus 로고    scopus 로고
    • 1-adrenergic receptor affect agonist-promoted trafficking
    • 1-adrenergic receptor affect agonist-promoted trafficking. J. Cardiovasc. Pharmacol. 39 (2002) 155-160
    • (2002) J. Cardiovasc. Pharmacol. , vol.39 , pp. 155-160
    • Rathz, D.A.1
  • 10
    • 0038576293 scopus 로고    scopus 로고
    • 2-adrenergic receptor signaling
    • 2-adrenergic receptor signaling. J. Biol. Chem. 278 (2003) 10784-10789
    • (2003) J. Biol. Chem. , vol.278 , pp. 10784-10789
    • Rathz, D.A.1
  • 12
    • 0041506933 scopus 로고    scopus 로고
    • Pharmacology and physiology of human adrenergic receptor polymorphisms
    • Small K.M., et al. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 381-411
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 381-411
    • Small, K.M.1
  • 13
    • 1542347133 scopus 로고    scopus 로고
    • Autonomic nervous system pharmacogenomics: a progress report
    • Kirstein S.L., and Insel P.A. Autonomic nervous system pharmacogenomics: a progress report. Pharmacol. Rev. 56 (2004) 31-52
    • (2004) Pharmacol. Rev. , vol.56 , pp. 31-52
    • Kirstein, S.L.1    Insel, P.A.2
  • 16
    • 0027519404 scopus 로고
    • 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor
    • 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J. Biol. Chem. 268 (1993) 23116-23121
    • (1993) J. Biol. Chem. , vol.268 , pp. 23116-23121
    • Green, S.A.1
  • 17
    • 0029836349 scopus 로고    scopus 로고
    • 2-adrenergic receptor polymorphism expressed in transgenic mice
    • 2-adrenergic receptor polymorphism expressed in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 10483-10488
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 10483-10488
    • Turki, J.1
  • 18
    • 0028068550 scopus 로고
    • 2-adrenergic receptor impart distinct agonist-promoted regulatory properties
    • 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 33 (1994) 9414-9419
    • (1994) Biochemistry , vol.33 , pp. 9414-9419
    • Green, S.A.1
  • 19
    • 33645025622 scopus 로고    scopus 로고
    • 1-adrenoceptor gene and aerobic power in coronary artery disease
    • 1-adrenoceptor gene and aerobic power in coronary artery disease. Eur. Heart J. 27 (2006) 808-816
    • (2006) Eur. Heart J. , vol.27 , pp. 808-816
    • Defoor, J.1
  • 20
    • 0036591589 scopus 로고    scopus 로고
    • Variability within α- and β-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge
    • McCaffery J.M., et al. Variability within α- and β-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge. J. Hypertens. 20 (2002) 1105-1114
    • (2002) J. Hypertens. , vol.20 , pp. 1105-1114
    • McCaffery, J.M.1
  • 21
    • 2942731307 scopus 로고    scopus 로고
    • Genetic polymorphisms of the β-adrenergic system: association with essential hypertension and response to β-blockade
    • Filigheddu F., et al. Genetic polymorphisms of the β-adrenergic system: association with essential hypertension and response to β-blockade. Pharmacogenomics J. 4 (2004) 154-160
    • (2004) Pharmacogenomics J. , vol.4 , pp. 154-160
    • Filigheddu, F.1
  • 22
    • 0038772374 scopus 로고    scopus 로고
    • 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol
    • 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin. Pharmacol. Ther. 74 (2003) 44-52
    • (2003) Clin. Pharmacol. Ther. , vol.74 , pp. 44-52
    • Johnson, J.A.1
  • 23
    • 0033821403 scopus 로고    scopus 로고
    • 1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjects
    • 1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjects. Clin. Sci. (Lond.) 99 (2000) 233-238
    • (2000) Clin. Sci. (Lond.) , vol.99 , pp. 233-238
    • O'Shaughnessy, K.M.1
  • 24
    • 2542618304 scopus 로고    scopus 로고
    • 1-adrenergic receptor blockade in patients with essential hypertension
    • 1-adrenergic receptor blockade in patients with essential hypertension. Clin. Cardiol. 27 (2004) 347-350
    • (2004) Clin. Cardiol. , vol.27 , pp. 347-350
    • Karlsson, J.1
  • 25
    • 33745353777 scopus 로고    scopus 로고
    • 1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension
    • 1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. Clin. Pharmacol. Ther. 80 (2006) 23-32
    • (2006) Clin. Pharmacol. Ther. , vol.80 , pp. 23-32
    • Liu, J.1
  • 26
    • 0033017630 scopus 로고    scopus 로고
    • 2-Adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians
    • 2-Adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians. Hypertension 33 (1999) 1425-1430
    • (1999) Hypertension , vol.33 , pp. 1425-1430
    • Gratze, G.1
  • 27
    • 12244265520 scopus 로고    scopus 로고
    • 2-adrenergic receptor polymorphism and nitric oxide-dependent forearm blood flow responses to isoproterenol in humans
    • 2-adrenergic receptor polymorphism and nitric oxide-dependent forearm blood flow responses to isoproterenol in humans. J. Physiol. 546 (2003) 583-589
    • (2003) J. Physiol. , vol.546 , pp. 583-589
    • Garovic, V.D.1
  • 28
    • 0035807591 scopus 로고    scopus 로고
    • 2-adrenergic receptor on agonist-mediated vascular desensitization
    • 2-adrenergic receptor on agonist-mediated vascular desensitization. N. Engl. J. Med. 345 (2001) 1030-1035
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1030-1035
    • Dishy, V.1
  • 29
    • 24344482075 scopus 로고    scopus 로고
    • 2-adrenergic receptor gene haplotypes and venodilation in vivo
    • 2-adrenergic receptor gene haplotypes and venodilation in vivo. Clin. Pharmacol. Ther. 78 (2005) 232-238
    • (2005) Clin. Pharmacol. Ther. , vol.78 , pp. 232-238
    • Bruck, H.1
  • 30
    • 0035852634 scopus 로고    scopus 로고
    • 2-adrenergic signaling in adult mouse cardiac myocytes
    • 2-adrenergic signaling in adult mouse cardiac myocytes. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 1607-1612
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 1607-1612
    • Zhu, W.Z.1
  • 31
    • 0037823079 scopus 로고    scopus 로고
    • 1-adrenergic receptor in patients with nonfatal acute myocardial infarction
    • 1-adrenergic receptor in patients with nonfatal acute myocardial infarction. Am. Heart J. 146 (2003) 106-109
    • (2003) Am. Heart J. , vol.146 , pp. 106-109
    • Iwai, C.1
  • 32
    • 4444382138 scopus 로고    scopus 로고
    • 2-adrenoceptor polymorphisms in heart failure: a case-control study
    • 2-adrenoceptor polymorphisms in heart failure: a case-control study. Eur. Heart J. 25 (2004) 1534-1541
    • (2004) Eur. Heart J. , vol.25 , pp. 1534-1541
    • Covolo, L.1
  • 33
    • 0037057235 scopus 로고    scopus 로고
    • 2C-adrenergic receptors and the risk of congestive heart failure
    • 2C-adrenergic receptors and the risk of congestive heart failure. N. Engl. J. Med. 347 (2002) 1135-1142
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1135-1142
    • Small, K.M.1
  • 34
    • 33646183895 scopus 로고    scopus 로고
    • 2-adrenergic receptor genetic variants and risk of sudden cardiac death
    • 2-adrenergic receptor genetic variants and risk of sudden cardiac death. Circulation 113 (2006) 1842-1848
    • (2006) Circulation , vol.113 , pp. 1842-1848
    • Sotoodehnia, N.1
  • 35
    • 26644458103 scopus 로고    scopus 로고
    • The impact of β-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure
    • de Groote P., et al. The impact of β-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure. Eur. J. Heart Fail. 7 (2005) 966-973
    • (2005) Eur. J. Heart Fail. , vol.7 , pp. 966-973
    • de Groote, P.1
  • 36
    • 0037385575 scopus 로고    scopus 로고
    • 1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to β-blockade
    • 1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to β-blockade. Clin. Pharmacol. Ther. 73 (2003) 366-371
    • (2003) Clin. Pharmacol. Ther. , vol.73 , pp. 366-371
    • Sofowora, G.G.1
  • 37
    • 28244477593 scopus 로고    scopus 로고
    • 1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity
    • 1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. J. Am. Coll. Cardiol. 46 (2005) 2111-2115
    • (2005) J. Am. Coll. Cardiol. , vol.46 , pp. 2111-2115
    • Bruck, H.1
  • 38
    • 0142073817 scopus 로고    scopus 로고
    • 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure
    • 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nat. Med. 9 (2003) 1300-1305
    • (2003) Nat. Med. , vol.9 , pp. 1300-1305
    • Mialet Perez, J.1
  • 39
    • 33746603033 scopus 로고    scopus 로고
    • 1-adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure
    • 1-adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 11288-11293
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 11288-11293
    • Liggett, S.B.1
  • 40
    • 40949113720 scopus 로고    scopus 로고
    • 2-adrenoceptor polymorphisms and cardiovascular diseases
    • 2-adrenoceptor polymorphisms and cardiovascular diseases. Fundam. Clin. Pharmacol. 22 (2008) 107-125
    • (2008) Fundam. Clin. Pharmacol. , vol.22 , pp. 107-125
    • Brodde, O.E.1
  • 41
    • 36649009124 scopus 로고    scopus 로고
    • 2-adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses
    • 2-adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses. Pharmacol. Ther. 117 (2008) 1-29
    • (2008) Pharmacol. Ther. , vol.117 , pp. 1-29
    • Brodde, O.E.1
  • 42
    • 0024519931 scopus 로고
    • Structural basis of β-adrenergic receptor function
    • Strader C.D., et al. Structural basis of β-adrenergic receptor function. FASEB J. 3 (1989) 1825-1832
    • (1989) FASEB J. , vol.3 , pp. 1825-1832
    • Strader, C.D.1
  • 44
    • 0034529234 scopus 로고    scopus 로고
    • 2-adrenergic receptor
    • 2-adrenergic receptor. J. Biol. Chem. 275 (2000) 37779-37788
    • (2000) J. Biol. Chem. , vol.275 , pp. 37779-37788
    • Liapakis, G.1
  • 45
    • 0024344941 scopus 로고
    • Identification of two serine residues involved in agonist activation of the β-adrenergic receptor
    • Strader C.D., et al. Identification of two serine residues involved in agonist activation of the β-adrenergic receptor. J. Biol. Chem. 264 (1989) 13572-13578
    • (1989) J. Biol. Chem. , vol.264 , pp. 13572-13578
    • Strader, C.D.1
  • 46
    • 0036729484 scopus 로고    scopus 로고
    • Seven-transmembrane receptors
    • Pierce K.L., et al. Seven-transmembrane receptors. Nat. Rev. Mol. Cell Biol. 3 (2002) 639-650
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 639-650
    • Pierce, K.L.1
  • 47
    • 0034604451 scopus 로고    scopus 로고
    • Crystal structure of rhodopsin: a G protein-coupled receptor
    • Palczewski K., et al. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289 (2000) 739-745
    • (2000) Science , vol.289 , pp. 739-745
    • Palczewski, K.1
  • 48
    • 33750836895 scopus 로고    scopus 로고
    • Crystal structure of a photoactivated deprotonated intermediate of rhodopsin
    • Salom D., et al. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 16123-16128
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 16123-16128
    • Salom, D.1
  • 49
    • 36248970132 scopus 로고    scopus 로고
    • 2-adrenergic G-protein-coupled receptor
    • 2-adrenergic G-protein-coupled receptor. Nature 450 (2007) 383-387
    • (2007) Nature , vol.450 , pp. 383-387
    • Rasmussen, S.G.1
  • 50
    • 36448995359 scopus 로고    scopus 로고
    • 2-adrenergic G protein-coupled receptor
    • 2-adrenergic G protein-coupled receptor. Science 318 (2007) 1258-1265
    • (2007) Science , vol.318 , pp. 1258-1265
    • Cherezov, V.1
  • 51
    • 36448978229 scopus 로고    scopus 로고
    • 2-adrenergic receptor function
    • 2-adrenergic receptor function. Science 318 (2007) 1266-1273
    • (2007) Science , vol.318 , pp. 1266-1273
    • Rosenbaum, D.M.1
  • 52
    • 47949129742 scopus 로고    scopus 로고
    • 1-adrenergic G-protein-coupled receptor
    • 1-adrenergic G-protein-coupled receptor. Nature 454 (2008) 486-491
    • (2008) Nature , vol.454 , pp. 486-491
    • Warne, T.1
  • 53
    • 0032541084 scopus 로고    scopus 로고
    • G protein-coupled receptors. II. Mechanism of agonist activation
    • Gether U., and Kobilka B.K. G protein-coupled receptors. II. Mechanism of agonist activation. J. Biol. Chem. 273 (1998) 17979-17982
    • (1998) J. Biol. Chem. , vol.273 , pp. 17979-17982
    • Gether, U.1    Kobilka, B.K.2
  • 54
    • 33646162635 scopus 로고    scopus 로고
    • GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling
    • Reiter E., and Lefkowitz R.J. GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol. Metab. 17 (2006) 159-165
    • (2006) Trends Endocrinol. Metab. , vol.17 , pp. 159-165
    • Reiter, E.1    Lefkowitz, R.J.2
  • 55
    • 0028856707 scopus 로고
    • 2-adrenergic receptor. Evidence for ligand-specific conformational changes
    • 2-adrenergic receptor. Evidence for ligand-specific conformational changes. J. Biol. Chem. 270 (1995) 28268-28275
    • (1995) J. Biol. Chem. , vol.270 , pp. 28268-28275
    • Gether, U.1
  • 56
    • 0035937786 scopus 로고    scopus 로고
    • 2-adrenergic receptor mapped by site-selective fluorescent labeling
    • 2-adrenergic receptor mapped by site-selective fluorescent labeling. J. Biol. Chem. 276 (2001) 9279-9290
    • (2001) J. Biol. Chem. , vol.276 , pp. 9279-9290
    • Jensen, A.D.1
  • 57
    • 0035816704 scopus 로고    scopus 로고
    • 2-adrenergic receptor
    • 2-adrenergic receptor. J. Biol. Chem. 276 (2001) 24433-24436
    • (2001) J. Biol. Chem. , vol.276 , pp. 24433-24436
    • Ghanouni, P.1
  • 59
    • 0345791508 scopus 로고    scopus 로고
    • 2-adrenoceptor. Kinetic evidence for intermediate conformational states
    • 2-adrenoceptor. Kinetic evidence for intermediate conformational states. J. Biol. Chem. 279 (2004) 686-691
    • (2004) J. Biol. Chem. , vol.279 , pp. 686-691
    • Swaminath, G.1
  • 60
    • 20444499405 scopus 로고    scopus 로고
    • 2-adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists
    • 2-adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. J. Biol. Chem. 280 (2005) 22165-22171
    • (2005) J. Biol. Chem. , vol.280 , pp. 22165-22171
    • Swaminath, G.1
  • 61
    • 84981779372 scopus 로고
    • Zwischenmolekulare Energiewanderung und Fluoreszenz
    • Förster T. Zwischenmolekulare Energiewanderung und Fluoreszenz. Annals of Physics (Leipzig) 2 (1948) 55-75
    • (1948) Annals of Physics (Leipzig) , vol.2 , pp. 55-75
    • Förster, T.1
  • 62
    • 33645798851 scopus 로고    scopus 로고
    • The fluorescent toolbox for assessing protein location and function
    • Giepmans B.N., et al. The fluorescent toolbox for assessing protein location and function. Science 312 (2006) 217-224
    • (2006) Science , vol.312 , pp. 217-224
    • Giepmans, B.N.1
  • 63
    • 33845973320 scopus 로고    scopus 로고
    • 1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol
    • 1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. J. Clin. Invest. 117 (2007) 229-235
    • (2007) J. Clin. Invest. , vol.117 , pp. 229-235
    • Rochais, F.1
  • 64
    • 0032503999 scopus 로고    scopus 로고
    • Specific covalent labeling of recombinant protein molecules inside live cells
    • Griffin B.A., et al. Specific covalent labeling of recombinant protein molecules inside live cells. Science 281 (1998) 269-272
    • (1998) Science , vol.281 , pp. 269-272
    • Griffin, B.A.1
  • 65
    • 20844434337 scopus 로고    scopus 로고
    • A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells
    • Hoffmann C., et al. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nat. Methods 2 (2005) 171-176
    • (2005) Nat. Methods , vol.2 , pp. 171-176
    • Hoffmann, C.1
  • 66
    • 62949185713 scopus 로고    scopus 로고
    • Dorsch, S. et al. Analysis of receptor oligomerization by FRAP microscopy. Nat. Methods. (in press)
    • Dorsch, S. et al. Analysis of receptor oligomerization by FRAP microscopy. Nat. Methods. (in press)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.