ACE inhibitors worsen inflammatory pain

Medical Hypotheses

Volumn 72, Issue 6, 2009, Pages 757-

  Fein, Alan ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ARGININE CARBOXYPEPTIDASE; BETA 2 ADRENERGIC RECEPTOR; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; KALLIKREIN; KININOGEN;

BLOOD VESSEL; CELL CULTURE; ENDOTHELIUM CELL; ENZYME DEGRADATION; HUMAN; HYPERALGESIA; HYPERTENSION; LETTER; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN FOLDING; TISSUE INJURY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BRADYKININ; HUMANS; INFLAMMATION; MODELS, BIOLOGICAL; PAIN;

EID: 62949103540     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.01.012     Document Type: Letter

References (5)

1. Guasti L., et al. Treatment with enalapril modifies the pain perception pattern in hypertensive patients. Hypertension 31 5 (1998) 1146-1150
2. Irvine R.J., White J.M., and Head R.J. The renin angiotensin system and nociception in spontaneously hypertensive rats. Life Sci 56 13 (1995) 1073-1078
3. Manning D.C., et al. Pain and hyperalgesia after intradermal injection of bradykinin in humans. Clin Pharmacol Ther 50 6 (1991) 721-729
4. Grafe M., et al. Effect of angiotensin-converting-enzyme inhibition on bradykinin metabolism by vascular endothelial cells. Am J Physiol 264 5 Pt 2 (1993) H1493-H1497
5. Erdos E.G., Deddish P.A., and Marcic B.M. Potentiation of bradykinin actions by ACE inhibitors. Trends Endocrinol Metab 10 6 (1999) 223-229