Dispersion of refractoriness in a simulated ischemic 2D tissue and implications in vulnerability to reentry

Computers in Cardiology

Volumn 34, Issue , 2007, Pages 313-316

  Trenor B ^a   Romero, L ^a   Ferrero, J M ^a   Saiz J ^a   Molto G ^a   Hernandez V ^a  

^a UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIALS; AXIAL CURRENTS; COMPUTATIONAL WORKS; DISPERSION DEGREES; EXPERIMENTAL STUDIES; ISCHEMIC TISSUES; MYOCARDIAL ISCHEMIAS; REALISTIC MODELS; TWO-DIMENSIONAL; UNIMODAL; VENTRICULAR ARRHYTHMIAS;

CARDIOLOGY; DISPERSION (WAVES);

DISPERSIONS;

EID: 62949089142     PISSN: 02766574     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/CIC.2007.4745484     Document Type: Conference Paper

References (18)

1. Janse MJ, Kleber AG. Electrophysiological changes and ventricular arrhythmias in the early phase of regional myocardial ischemia. Circ Res 1981;49:1069-1081.
2. de Groot JR, Coronel R. Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis. Cardiovasc Res 2004;62:323-334.
3. Ferrero JM, Jr., Saiz J, Ferrero JM, Thakor NV. Simulation of action potentials from metabolically impaired cardiac myocytes. Role of ATP-sensitive K+ current. Circ Res 1996;79:208-221.
4. Weiss JN, Venkatesh N, Lamp ST. ATP-sensitive K+ channels and cellular K+ loss in hypoxic and ischaemic mammalian ventricle. J Physiol 1992;447:649-673.
5. Boersma L, Zetelaki Z, Brugada J, Allessie M. Polymorphic reentrant ventricular tachycardia in the isolated rabbit heart studied by high-density mapping. Circulation 2002;105:3053-3061.
6. Kuo,C.-S., C.P.Reddy, K.Munakata, and B.Surawicz. 1985. Arrhythmias dependent predominantly on dispersion of repolarization. Cardiac Electrphysiology and Arrhythmias 1985; 277-285.
7. Bardou AL, Auger PM, Achour S, Dumee P, Birkui PJ, Govaere MC. Effect of myocardial infarction and ischemia on induction of cardiac reentries and ventricular fibrillation. Acta Biotheor 1995;43:363-372.
8. Clayton RH, Holden AV. Dispersion of cardiac action potential duration and the initiation of re-entry: a computational study. Biomed Eng Online 2005;4:11.
9. Faber GM, Rudy Y. Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophys J 2000;78:2392-2404.
10. Trenor B, Ferrero JM, Rodriguez B, Montilla F. Effects of pinacidil on reentrant arrhythmias generated during acute regional ischemia: A simulation study. Annals of Biomedical Engineering 2005;33:897-906.
11. Coronel R, Fiolet JW, Wilms-Schopman FJ, Schaapherder AF, Johnson TA, Gettes LS, Janse MJ. Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart. Circulation 1988;77:1125-1138.
12. Ferrero JM, Jr., Trenor B, Rodriguez B, Saiz J. Electrical activity and reentry during acute regional myocardial ischemia: insights from simulations. International Journal of Bifurcation and Chaos 2003;13:67-78.
13. Gough WB, Mehra R, Restivo M, Zeiler RH, el Sherif N. Reentrant ventricular arrhythmias in the late myocardial infarction period in the dog. 13. Correlation of activation and refractory maps. Circ Res 1985;57:432-442.
14. Namba T, Ashihara T, Nakazawa K, Ohe T. Spatial heterogeneity in refractoriness as a proarrhythmic substrate: theoretical evaluation by numerical simulation. Jpn Circ J 2000;64:121-129.
15. Qu Z, Karagueuzian HS, Garfinkel A, Weiss JN. Effects of Na(+) channel and cell coupling abnormalities on vulnerability to reentry: a simulation study. Am J Physiol Heart Circ Physiol 2004;286:H1310-H1321.
16. Laurita KR, Rosenbaum DS. Interdependence of modulated dispersion and tissue structure in the mechanism of unidirectional block. Circ Res 2000;87:922-928.
17. Rogers JM. Wave front fragmentation due to ventricular geometry in a model of the rabbit heart. Chaos 2002;12:779-787.
18. Picard S, Rouet R, Ducouret P, Puddu PE, Flais F, Criniti A, Monti F, Gerard JL. KATP channels and 'border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions. Br J Pharmacol 1999;127:1687-1695.