Drug pressure selected mutations in HIV-1 protease alter flap conformations

Journal of the American Chemical Society

Volumn 131, Issue 2, 2009, Pages 430-431

  Galiano, Luis ^a   Ding, Fangyu ^b   Veloro, Angelo M ^a   Blackburn, Mandy E ^a   Simmerling, Carlos ^b   Fanucci, Gail E ^a  

^a University of Florida ^*  (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRAL THERAPY; COMBINED ANALYSIS; DISTANCE PROFILES; HIV-1 PROTEASE; MD SIMULATION; MOLECULAR DYNAMIC SIMULATIONS; MULTIPLE MUTATIONS; PULSED ELECTRON; STRUCTURAL INSIGHTS; STRUCTURAL INTERPRETATION;

CONFORMATIONS; ELECTRON RESONANCE; MOLECULAR DYNAMICS; PARAMAGNETIC RESONANCE; PARAMAGNETISM; QUANTUM THEORY;

ELECTRON SPIN RESONANCE SPECTROSCOPY;

PROTEINASE; P16 PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1; PROTEINASE INHIBITOR;

ARTICLE; CONFORMATION; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DYNAMICS; MUTATION; SIMULATION; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; METABOLISM; PROTEIN CONFORMATION;

CATALYTIC DOMAIN; COMPUTER SIMULATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION;

EID: 62849123601     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja807531v     Document Type: Article

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