The 'hot cross bun' sign in the patients with spinocerebellar ataxia

European Journal of Neurology

Volumn 16, Issue 4, 2009, Pages 513-516

  Lee, Y C ^a,b   Liu, C S ^c,d   Wu, H M ^b   Wang, P S ^a,e   Chang, M H ^a,f   Soong, B W ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI MUNICIPAL GAN DAU HOSPITAL   (Taiwan)

^f TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

'hot cross bun' sign; MSA; Pontine midline hyperintensity; SCA

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; DIFFERENTIAL DIAGNOSIS; FEMALE; GENOTYPE; HOT CROSS BUN SIGN; HUMAN; IMAGE DISPLAY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PONTINE MIDLINE HYPERINTENSITY; PREVALENCE; PRIORITY JOURNAL; SPINOCEREBELLAR DEGENERATION;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PONS; RETROSPECTIVE STUDIES; SEQUENCE ANALYSIS, DNA; SPINOCEREBELLAR ATAXIAS; TRINUCLEOTIDE REPEAT EXPANSION; YOUNG ADULT;

EID: 62849123060     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2008.02524.x     Document Type: Article

References (21)

1. Watanabe H, Saito Y, Terao S, et al. Progression and prognosis in multiple system atrophy - an analysis of 230 Japanese patients. Brain 2002 125 : 1070 1083.
2. Abele M, Bürk K, Schöls L, et al. The aetiology of sporadic adult-onset ataxia. Brain 2002 125 : 961 968.
3. Schöls L, Szymanski S, Peters S, et al. Genetic background of apparently idiopathic sporadic cerebellar ataxia. Human Genetics 2000 107 : 132 137.
4. Horimoto Y, Aiba I, Yasuda T, et al. Longitudinal MRI study of multiple system atrophy - when do the findings appear, and what is the course? Journal of Neurology 2002 249 : 847 854.
5. Soong BW, Paulson HL. Spinocerebellar ataxias: an update. Current Opinion in Neurology 2007 20 : 438 446.
6. Van de Leemput J, Chandran J, Knight MA, et al. Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. PLoS Genetics 2007 3 : e108.
7. Bürk K, Skalej M, Dichgans J. Pontine MRI hyperintensities ("the cross sign") are not pathognomonic for multiple system atrophy. Movement disorder 2001 16 : 535 536.
8. Murata Y, Yamaguchi S, Kawakami H, et al. Characteristic magnetic resonance imaging findings in Machado-Joseph disease. Archives of Neurology 1998 55 : 33 37.
9. Adachi M, Kawanami T, Ohshima H, Hosoya T. Characteristic signal changes in the pontine base on T2- and multishot diffusion-weighted images in spinocerebellar ataxia type 1. Neuroradiology 2006 48 : 8 13.
10. Soong BW, Lu YC, Choo KB, Lee HY. Frequency analysis of autosomal dominant cerebellar ataxias in Taiwanese patients and clinical and molecular characterization of spinocerebellar ataxia 6. Archives of Neurology 2001 58 : 1105 1109.
11. Muqit MMK, Mort D, Miszkiel KA, Shakir RA. "Hot-cross bun" sign in a patient with parkinsonism secondary to presumed vasculitis. Journal of Neurology, Neurosurgery and Psychiatry 2001 71 : 556 567.
12. Savoiardo M, Strada L, Girotti F, et al. Olivopontocerebellar atrophy: MR diagnosis and relationship to multisystem atrophy. Radiology 1990 174 : 693 696.
13. Takao M, Kadowaki T, Tomita Y, Yoshida Y, Mihara B. "Hot-cross bun sign" of multiple system atrophy. Internal Medicine 2007 46 : 1883.
14. Koeppen AH. The hereditary ataxia. Journal of Neuropathology and Experimental Neurology 1998 57 : 531 543.
15. Klockgether T, Skalej M, Wedekind D, et al. Autosomal dominant cerebellar ataxia type I. MRI-based volumetry of posterior fossa structures and basal ganglia in spinocerebellar ataxia types 1, 2, and 3. Brain 1998 121 : 1687 1693.
16. Murata Y, Kawakami H, Yamaguchi S, et al. Characteristic magnetic resonance imaging findings in spinocerebellar ataxia 6. Archives of Neurology 1998 55 : 1348 1352.
17. Schöls L, Bauer P, Schmidt T, et al. Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis. Lancet Neurology 2004 3 : 291 304.
18. Ito H, Kawakami H, Wate R, et al. Clinicopathologic investigation of a family with expanded SCA8 CTA/CTG repeats. Neurology 2006 67 : 1479 1481.
19. Wang PS, Liu RS, Yang BH, Soong BW. Regional patterns of cerebral glucose metabolism in spinocerebellar ataxia type 2, 3 and 6: a voxel-based FDG-positron emission tomography analysis. Journal of Neurology 2007 254 : 838 845.
20. Gomez CM, Thompson RM, Gammack JT, et al. Spinocerebellar ataxia type 6: gaze-evoked and vertical nystagmus, Purkinje cell degeneration, and variable age of onset. Annals of Neurology 1997 42 : 933 950.
21. Rolfs A, Koeppen AH, Bauer I, et al. Clinical features and neuropathology of autosomal dominant spinocerebellar ataxia (SCA17). Annals of Neurology 2003 54 : 367 375.