Valacyclovir neurotoxicity: Clinical experience and review of the literature

European Journal of Neurology

Volumn 16, Issue 4, 2009, Pages 457-460

  Asahi, T ^a   Tsutsui, M ^a   Wakasugi, M ^a   Tange, D ^a   Takahashi, C ^a   Tokui, K ^a   Okazawa, S ^a   Okudera, H ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Acyclovir; Herpes zoster; Neuropsychiatric; Neurotoxicity; Renal failure; Valacyclovir

Indexed keywords

VALACICLOVIR;

ACUTE KIDNEY FAILURE; AGED; ALZHEIMER DISEASE; CASE REPORT; CHRONIC KIDNEY FAILURE; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONSCIOUSNESS DISORDER; DRUG WITHDRAWAL; FEMALE; HALLUCINATION; HEMODIALYSIS; HERPES ZOSTER; HUMAN; MALE; NEUROTOXICITY; PRIORITY JOURNAL; REVIEW; TRIGEMINAL NERVE;

ACYCLOVIR; ADULT; AGED; ANTIVIRAL AGENTS; CONSCIOUSNESS DISORDERS; FEMALE; HALLUCINATIONS; HERPES ZOSTER; HUMANS; KIDNEY FAILURE, ACUTE; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; NEUROTOXICITY SYNDROMES; VALINE;

EID: 62849114528     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2008.02527.x     Document Type: Review

References (24)

1. GlaxoSmithKline, 2008. Prescribing information for VALTREX. http://us.gsk.com/products/assets/us-valtrex.pdf (accessed 06/01/2009).
2. Wu JJ, Brentjens MH, Torres G, Yeung-Yue K, Lee P, Tyring SK. Valacyclovir in the treatment of herpes simplex, herpes zoster, and other viral infections. Journal of Cutaneous Medicine and Surgery 2003 7 : 372 381.
3. Linssen-Schuurmans CD, van Kan EJ, Feith GW, Uges DR. Neurotoxicity caused by valacyclovir in a patient on hemodialysis. Therapeutic Drug Monitoring 1998 20 : 385 386.
4. Izzedine H, Mercadal L, Aymard G, et al. Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study. American Journal of Nephrology 2001 21 : 162 164.
5. Okada T, Nakao T, Matsumoto H, et al. Valacyclovir neurotoxicity in a patient with end-stage renal disease treated with continuous ambulatory peritoneal dialysis (in Japanese). Clinical Nephrology 2002 58 : 168 170.
6. Duane B. Valacyclovir neurotoxicity: two case reports and a review of the literature. Canadian Journal of Hospital Pharmacy 2002 55 : 123 127.
7. Iijima M, Hasegawa T, Shibata S, Miyagawa H, Uchigata M. Neurotoxicity of valacyclovir in a patient on hemodialysis (in Japanese). Neurological Medicine 2003 58 : 327 329.
8. Olin JL, Gugliotta JL. Possible valacyclovir-related neurotoxicity and aseptic meningitis. Annals of Pharmacotherapy 2003 37 : 1814 1817.
9. Rivkin AM. Valacyclovir-induced seizures in end-stage renal disease. Annals of Pharmacotherapy 2003 37 : 1913.
10. Strumia S, De Mitri P, Bionda E. Neurotoxicity of acyclovir and valacyclovir in a hemodialyzed patient. European Journal of Neurology 2004 11 : 68 69.
11. Nonaka M, Yuasa H, Shizukawa H, Chiba S, Matsumoto H. Aciclovir encephalopathy caused by valaciclovir in a patient on hemodialysis (in Japanese). Journal of the Japanese Society of Internal Medicine 2004 93 : 578 580.
12. Honda M. How to use antiviral agent acyclovir and valaciclovir hydrochloride in patients with renal failure (in Japanese). Journal of Clinical Therapeutics and Medicine 2004 20 : 579 586.
13. Furukubo T, Hirata S, Ota M, Fujita M, Izumi S, Yamakawa T. Adjustment of valacyclovir dosage for herpes zoster infection in patients undergoing hemodialysis (in Japanese). Japanese Journal of Pharmaceutical Health Care and Sciences 2004 30 : 547 552.
14. Carlon R, Possamai C, Corbanese U. Acute renal failure and severe neurotoxicity following valacyclovir. Intensive Care Medicine 2005 31 : 1593.
15. Aizawa K, Baba T, Jingami S, Fukunaga E. Importance of drug compliance instruction for patients with renal failure: a case of renal failure requiring dialysis due to an overdose of valacyclovir (in Japanese). Journal of Japanese Society of Hospital Pharmacists 2006 42 : 899 902.
16. Tsutsui M, Asahi T, Wakasugi M, Tange D, Okazawa S, Okudera H. Acyclovir-related neurotoxicity induced by valacyclovir - two case report - (in Japanese). Toyama Medical Journal 2006 1 : 33 36.
17. Helldén A, Odar-Cederlöf I, Larsson K, Fehrman-Ekholm I, Lindén T. Death delusion. BMJ 2007 335 : 1305.
18. Haefeli WE, Schoenenberger RA, Weiss P, Ritz RF. Acyclovir-induced neurotoxicity: concentration-side effect relationship in acyclovir overdose. American Journal of Medicine 1993 94 : 212 215.
19. Adair JC, Gold M, Bond RE. Acyclovir neurotoxicity: clinical experience and review of the literature. Southern Medical Journal 1994 87 : 1227 1231.
20. Tucker WE. Preclinical toxicology profile of acyclovir. American Journal of Medicine 1982 73 (suppl. 202 204.
21. Rashed A, Azadeh B, Abu Romeh SH. Acyclovir-induced acute tubule-interstitial nephritis. Nephron 1990 56 : 436 438.
22. Helldén A, Odar-Cederlof I, Diener P, et al. High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study. Nephrology Dialysis Transplantation 2003 18 : 1135 1141.
23. Helldén A, Lycke J, Vander T, Svensson JO, Odar-Cederlof I, Stahle L. The acyclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during acyclovir and valaciclovir treatment. The Journal of Antimicrobial Chemotherapy 2006 57 : 945 949.
24. GlaxoSmithKline, 2007. Prescribing information for VALTREX. http://glaxosmithkline.co.jp/medical/medicine/item/valtrex-tab500/ valtrex-tab500.pdf (in Japanese) (accessed 06/01/2009).