The effects of N-acetylcysteine on intestinal ischemia/reperfusion injury in rats

Saudi Medical Journal

Volumn 30, Issue 1, 2009, Pages 24-29

  Ayvaz, Suleyman ^a   Aksu, Burhan ^a   Inan, Mustafa ^a   Uzun, Hafize ^b   Aydin, Seval ^b   Bilgi, Selcuk ^a   Umit, Hasan C ^a   Pul, Mehmet ^a  

^a TRAKYA UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ASIST; GLUTATHIONE; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD LEVEL; CELL LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; HISTOPATHOLOGY; INTESTINE ISCHEMIA; NONHUMAN; RAT; REPERFUSION INJURY; TISSUE LEVEL; TREATMENT RESPONSE; TURKEY (REPUBLIC); WISTAR ALBINO GLAXO RAT;

ACETYLCYSTEINE; ANIMALS; INTESTINES; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 62849084588     PISSN: 03795284     EISSN: 16583175     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Sener G, Kaçmaz A, User Y, Ozkan S, Tilki M, Yegen BC. Melatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats. J Pineal Res 2003; 35: 163-168.
2. Zhang S, Chai FY, Yan H, Guo Y, Harding JJ. Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats. Mol Vis 2008; 14: 862-870.
3. Soltan-Sharifi MS, Mojtahedzadeh M, Najafi A, Reza Khajavi M, Reza Rouini M, Moradi M, et al. Improvement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power: evidence for underlying toxicological mechanisms. Hum Exp Toxicol 2007; 26: 697-703.
4. Wang H, Xu DX, Lu JW, Zhao L, Zhang C, Wei W. N-acetylcysteine attenuates lipopolysaccharide-induced apoptotic liver damage in D-galactosamine-sensitized mice. Acta Pharmacol Sin 2007; 28: 1803-1809.
5. Souza AL Jr, Poggetti RS, Fontes B, Birolini D. Gut ischemia/ reperfusion activates lung macrophages for tumor necrosis factor and hydrogen peroxide production. J Trauma 2000; 49: 232-236.
6. Chiu CJ, McArdle AH, Brown R, Scott HJ, Gurd FN. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg 1970; 101: 478-483.
7. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302-310.
8. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988; 34: 497-500.
9. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med 1963; 61: 882-888.
10. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 1982; 126: 131-138.
11. Park PO, Haglund U, Bulkley GB, Falt K. The sequence of development of intestinal tissue injury following strangulation ischemia and reperfusion. Surgery 1990; 107: 574-580.
12. Mallick IH, Yang W, Winslet MC, Seifalian AM. Ischemia-Reperfusion Injury of the Intestine and Protective Strategies Against Injury. Dig Dis Sci 2004; 49: 1359-1377.
13. Zimmerman BJ, Granger DN. Mechanisms of reperfusion injury. Am J Med Sci 1994; 307: 284-292.
14. Yasuhara H. Acute mesenteric ischemia: The challenge of gastroenterology. Surg Today 2005; 35: 185-195.
15. Sadowska AM, Manuel-y-Keenoy B, De Backer WA. Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo dose-effects: A review. Pulm Pharmacol Ther 2007; 20: 9-22.
16. Hazinedaroglu SM, Dulger F, Kayaoglu HA, Pehlivan M, Serinsoz E, Canbolat O, et al. N-acetylcysteine in intestinal reperfusion injury: An experimental study in rats. ANZ J Surg 2004; 74: 676-678.
17. Byrka-Owczarek K, Steplewska-Mazur K, Krason M, Bohosiewicz J, Koszutski T, Wojtynek G. The evaluation of the protective action of antioxidants on small intestine of rabbits experimentally injured by ischemia and reperfusion. J Pediatr Surg 2004; 39: 1226-1229.
18. Zhang C, Sheng ZY, Hu S, Gao JC, Li JY, Liu Y. The role of oxygen-free radical in the apoptosis of enterocytes in scalded rats after delayed resuscitation. J Trauma 2004; 56: 611-617.
19. Zafarullah M, Li WQ, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 2003; 60: 6-20.
20. Arican O, Kurutas EB, Sasmaz S. Oxidative stress in patients with acne vulgaris. Mediators Inflamm 2005; 14: 380-384.
21. Aksu B, Inan M, Kanter M, Oz Puyan F, Uzun H, Durmus-Altun G, et al. The effects of methylene blue on renal scarring due to pyelonephritis in rats. Pediatr Nephrol 2007; 22: 992-1001.
22. Guven A, Tunc T, Topal T, Kul M, Korkmaz A, Gundogdu G, et al. alpha-Lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine. Surg Today 2008; 38: 1029-1035.
23. Ceran C, Sönmez K, Türkyllmaz Z, Demirogullarl B, Dursun A, Düzgün E, et al. Effect of bilirubin in ischemia/reperfusion injury on rat small intestine. J Pediatr Surg 2001; 36: 1764-1767.
24. Börjesson A, Wang X, Sun Z, Wallén R, Deng X, Johansson E, Andersson R. Effects of N-acetylcysteine on pulmonary macrophage activity after intestinal ischemia and reperfusion in rats/with invited commentaries. Dig Surg 2000; 17: 379-387.