Gene-expression profiling of peripheral blood mononuclear cells in sepsis

Critical Care Medicine

Volumn 37, Issue 3, 2009, Pages 882-888

  Tang, Benjamin M P ^a   McLean, Anthony S ^a,b   Dawes, Ian W ^b   Huang, Stephen J ^a   Lin, Ruby C Y ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Gene expression; Microarray; Sepsis

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CROSS-SECTIONAL STUDY; DIAGNOSTIC ACCURACY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GRAM NEGATIVE SEPSIS; GRAM POSITIVE SEPSIS; HUMAN; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PATIENT REFERRAL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RNA EXTRACTION; SEPSIS; SUPPORT VECTOR MACHINE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TERTIARY HEALTH CARE; VENOUS BLOOD; BLOOD; GENETICS; MIDDLE AGED; MONONUCLEAR CELL;

AGED; CROSS-SECTIONAL STUDIES; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; SEPSIS;

EID: 62849083444     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31819b52fd     Document Type: Article

References (22)

1. Cobb J, O'Keefe G: Injury research in the genomic era. Lancet 2004; 363:2076-2083
2. Christie J: Microarrays. Crit Care Med 2005; 33:S449-S452
3. Tang B, McLean A, Dawes I, et al: The use of gene-expression profiling to identify candidate genes in human sepsis. Am J Respir Crit Care Med 2007; 176:676-684
4. Tang B, McLean A, Dawes I, et al: The gene-expression profiling of gram-positive and gram-negative sepsis in critically ill patients. Crit Care Med 2008; 36:1125-1128
5. Bochud P-Y, Glauser MP, Calandra T: Antibiotics in sepsis. Intensive Care Med 2001; 27(Supp 11):S33-S48
6. Calandra T, Cohen J: The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med 2005; 33:1538-1548
7. Knaus W, Draper E, Wagner D, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13: 818-829
8. Castella X, Artigas A, Bion J, et al: A comparison of severity of illness scoring systems for intensive care unit patients: Results of a mul-ticenter, multinational study. Crit Care Med 1995; 23:1327-1335
9. Simon R, Korn E, McShane L, et al: Design and Analysis of DNA Microarray Investigations. First Edition. New York, Springer, 2003
10. Korn E, Troendle J, McShane L, et al: Controlling the number of false discoveries: Application to high-dimensional genomic data. J Stat Plan Inf 2004; 124:379-398
11. Reiner A, Yekutieli D, Benjamini Y: Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 2003; 19:368-375
12. Chung J, Fraser D: Randomization tests for a multivariate two-sample problem. J Am Stat Assoc 1958; 53:729-735
13. Radmacher M, McShane L, Simon R: A paradigm for class prediction using gene expression profiles. J Comput Biol 2002; 9:505-511
14. Eisen M, Spellman P, Brown P, et al: Cluster analysis and display of genome-wide expression pattern. Proc Natl Acad Sci USA 1998; 95:14863-14868
15. Roth J, Vogl T, Sorg C, et al: Phagocyte-specific S100 proteins: A novel group of proinflammatory molecules. Trends Immunol 2003; 24:155-158
16. Hotchkiss R, Karl I: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348: 138-150
17. Marshall J: Neutrophils in the pathogenesis of sepsis. Crit Care Med 2005; 33(Suppl): S502-S505
18. Hotchkiss R, Tinsley K, Swanson P, et al: e: Sepsis-induced apoptosis causes progressive profound depletion of B and CD4(+) T lymphocytes in humans. J Immunol 2001; 166: 6952-6963
19. Fitting C, Dhawan S, Cavaillon J: Compart-mentalisation of endotoxin tolerance. J Infect Dis 2004; 189:1295-1303
20. Ge Y, Ezzell R, Clark B, et al: Relatinship of tissue and cellular interleukin-1 and li-popolysaccharide after endotoxemia and bacteremia. J Infect Dis 1997; 176: 1313-1321
21. Giroir B, Johnson J, Brown T, et al: The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia. J Clin Inves 1992; 90:693-698
22. Jenner R, Young R: Insights into host responses against pathogens from transcriptional profiling. Nat Rev Microbiol 2005; 3:281-294