A simple high-performance liquid chromatographic method for the determination of diclofenac in human plasma: Application to a comparative bioavailability study

International Journal of Clinical Pharmacology and Therapeutics

Volumn 47, Issue 2, 2009, Pages 132-140

  Rigato, H M ^a   Moreno, R A ^a,b   Orpinelli, E Z ^b   Borges, B C ^c   Sverdloff, C E ^a   Pedrazzoli, Jr ^d   Borges, N Carter ^a,b,e  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b Synchrophar Assessoria e Desenvolvimento de Projetos Clinicos   (Brazil)

^c PONTIFÍCIA UNIVERSIDADE CATÓLICA DE CAMPINAS   (Brazil)

^d Universidade Sao Francisco Centro de Ciencias Biologicas e da Saude   (Brazil)

^e NONE   (Brazil)

Author keywords

Bioavailability; Cholestyramine; Diclofenac; High performance liquid chromatography; Pharmacokinetics

Indexed keywords

DICLOFENAC; DICLOFENAC COLESTYRAMINE; INDOMETACIN; COLESTYRAMINE; NONSTEROID ANTIINFLAMMATORY AGENT;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CALIBRATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG DETERMINATION; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG STABILITY; FEMALE; GEOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OPEN STUDY; PRECIPITATION; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRAVIOLET SPECTROSCOPY; VOLUNTEER; BIOAVAILABILITY; DRUG COMBINATION; METHODOLOGY; MICROCAPSULE; PHARMACOKINETICS; REPRODUCIBILITY;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CAPSULES; CHOLESTYRAMINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; DICLOFENAC; DRUG COMBINATIONS; FEMALE; HUMANS; MALE; REPRODUCIBILITY OF RESULTS; THERAPEUTIC EQUIVALENCY; YOUNG ADULT;

EID: 62749201466     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP47132     Document Type: Article

References (28)

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