Clinical analysis and follow-up study of chronic active Epstein-Barr virus infection in 53 pediatric cases

Chinese Medical Journal

Volumn 122, Issue 3, 2009, Pages 262-266

  Lu, Gen ^a   Xie, Zheng De ^a   Zhao, Shun Ying ^a   Ye, Ling Jun ^a   Wu, Run Hui ^a   Liu, Chun Yan ^a   Yang, Shuang ^a   Jin, Ying Kang ^a   Shen, Kun Ling ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Chronic active Epstein Barr virus infection; Clinical features; Risk factors

Indexed keywords

ALBUMIN; VIRUS DNA; VIRUS RNA;

ADOLESCENT; ALBUMIN BLOOD LEVEL; ARTICLE; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; EPSTEIN BARR VIRUS; FEMALE; FEVER; FOLLOW UP; HEMOPHAGOCYTIC SYNDROME; HEPATOMEGALY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; INFECTIOUS MONONUCLEOSIS; INTERSTITIAL PNEUMONIA; LABORATORY TEST; LIVER FAILURE; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; ONSET AGE; RETROSPECTIVE STUDY; SPLENOMEGALY; SYMPTOM; THROMBOCYTE COUNT; VIRUS INFECTION;

ADOLESCENT; AGE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; CHINA; CHRONIC DISEASE; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; MALE; RISK FACTORS; SERUM ALBUMIN; THROMBOCYTOPENIA;

EID: 62749193565     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2009.03.005     Document Type: Article

References (19)

1. Cohen JI. Epstein-Barr virus infection. N Engl J Med 2000; 343: 481-492.
2. de Boer M, Mol MJ, Bogman MJ, Galama JM, Raymakers RA. Chronic active Epstein-Barr virus infection in an adult with no detectable immune deficiency. Neth J Med 2003; 61: 376-382.
3. Straus SE. The chronic mononucleosis syndrome. J Infect Dis 1988; 157: 405-412.
4. Wakiguchi H. Overview of Epstein-Barr virus-associated diseases in Japan. Crit Rev Oncol Hematol 2002; 44: 193-202.
5. Chiba T, Goto S, Yokosuka O, Imazeki F, Tanaka M, Fukai K, et al. Fatal chronic active Epstein-Barr virus infection mimicking autoimmune hepatitis. Eur J Gastroenterol Hepatol 2004; 16: 225-228.
6. Shibuya A, Tsuchihashi T, Watanabe M, Nakazawa T, Takeuchi A, Sakurai K, et al. Severe chronic active Epstein-Barr virus infection associated with multiple necrotic lesions in the liver. Hepatol Res 2003; 25: 447-454.
7. Fujieda M, Wakiguchi H, Hisakawa H, Kubota H, Kurashige T. Defective activity of Epstein-Barr virus (EBV) specific cytotoxic T lymphocytes in children with chronic active EBV infection and in their parents. Acta Paediatr Jpn 1993; 35: 394-399.
8. Maia DM, Peace-Brewer AL. Chronic, active Epstein-Barr virus infection. Curr Opin Hematol 2000; 7: 59-63.
9. Savoldo B, Huls MH, Liu Z, Okamura T, Volk HD, Reinke P, et al. Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection. Blood 2002; 100: 4059-4066.
10. Kimura H. Pathogenesis of chronic active Epstein-Barr virus infection: is this an infectious disease, lymphoproliferative disorder, or immunodeficiency? Rev Med Virol 2006; 16: 251-261.
11. Kimura H, Hoshino Y, Hara S, Sugaya N, Kawada J, Shibata Y, et al. Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection. J Infect Dis 2005; 191: 531-539.
12. Kimura H, Hoshino Y, Kanegane H, Tsuge I, Okamura T, Kawa K, et al. Clinical and virologic characteristics of chronic active Epstein-Barr virus infection. Blood 2001; 98: 280-286.
13. Quintanilla-Martinez L, Kumar S, Fend F, Reyes E, Teruya-Feldstein J, Kingma DW, et al. Fulminant EBV(+) T-cell lymphoproliferative disorder following acute/chronic EBV infection: a distinct clinicopathologic syndrome. Blood 2000; 96: 443-451.
14. Maeda A, Wakiguchi H, Yokoyama W, Hisakawa H, Tomoda T, Kurashige T. Persistently high Epstein-Barr virus (EBV) loads in peripheral blood lymphocytes from patients with chronic active EBV infection. J Infect Dis 1999; 179: 1012-1015.
15. Patel S, Zuckerman M, Smith M. Real-time quantitative PCR of Epstein-Barr virus BZLF1 DNA using the LightCycler. J Virol Methods 2003; 109: 227-233.
16. Ohshima K, Suzumiya J, Sugihara M, Nagafuchi S, Ohga S, Kikuchi M. Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome. Pathol Int 1998; 48: 934-943.
17. Okano M, Kawa K, Kimura H, Yachie A, Wakiguchi H, Maeda A, et al. Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection. Am J Hematol 2005; 80: 64-69.
18. Ishihara S, Okada S, Wakiguchi H, Kurashige T, Morishima T, Kawa-Ha K. Chronic active Epstein-Barr virus infection in children in Japan. Acta Paediatr 1995; 84: 1271-1275.
19. Kimura H, Morishima T, Kanegane H, Ohga S, Hoshino Y, Maeda A, et al. Prognostic factors for chronic active Epstein-Barr virus infection. J Infect Dis 2003; 187: 527-533.