A novel powder sample holder for the determination of glass transition temperatures by DMA

International Journal of Pharmaceutics

Volumn 371, Issue 1-2, 2009, Pages 120-125

  Mahlin, Denny ^a   Wood, John ^a   Hawkins, Nicholas ^b   Mahey, Jas ^c   Royall, Paul G ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b The Fleming Centre ^*  (United Kingdom)

^c TA INSTRUMENTS   (United States)

Author keywords

Amorphous content; Amorphous powders; Dynamic mechanical analysis (DMA); Glass transition; HPMC; Powder holder

Indexed keywords

ALUMINUM OXIDE; HYDROXYPROPYLMETHYLCELLULOSE;

ANALYTIC METHOD; ARTICLE; DRY POWDER; DYNAMIC MECHANICAL ANALYSIS; EQUIPMENT DESIGN; GLASS TRANSITION TEMPERATURE; POWDER SAMPLE HOLDER; PRIORITY JOURNAL;

DRUG COMPOUNDING; ELASTICITY; EQUIPMENT DESIGN; HOT TEMPERATURE; METHYLCELLULOSE; PHASE TRANSITION; POWDERS; STRESS, MECHANICAL; VISCOSITY;

EID: 62749182232     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.12.039     Document Type: Article

References (13)

1. Angell C.A. Formation of glasses from liquids and biopolymers. Science 267 (1995) 1924-1935
2. Bandi S., and Schiraldi D.A. Glass transition behavior of clay aerogel/poly(vinyl alcohol) composites. Macromolecules 39 (2006) 6537-6545
3. Craig D.Q.M., Royall P.G., Kett V.L., and Hopton M.L. The relevance of the amorphous state to pharmaceutical dosage forms: glassy drugs and freeze dried systems. Int. J. Pharm. 179 (1999) 179-207
4. Debenedetti P.G., and Stillinger F.H. Supercooled liquids and the glass transition. Nature 410 (2001) 259-267
5. Fragiadakis D., Pissis P., and Bokobza L. Glass transition and molecular dynamics in poly (dimethylsiloxane)/silica nanocomposites. Polymer 46 (2005) 6001-6008
6. Huang D.H., and McKenna G.B. New insights into the fragility dilemma in liquids. J. Chem. Phys. 114 (2001) 5621-5630
7. Kararli T.T., Hurlbut J.B., and Needham T.E. Glass rubber transitions of cellulosic polymers by dynamic mechanical analysis. J. Pharm. Sci. 79 (1990) 845-848
8. Mao C., Chamarthy S.P., and Pinal R. Time-dependence of molecular mobility during structural relaxation and its impact on organic amorphous solids: an investigation based on a calorimetric approach. Pharm. Res. 23 (2006) 1906-1917
9. McPhillips H., Craig D.Q.M., Royall P.G., and Hill V.L. Characterisation of the glass transition of HPMC using modulated temperature differential scanning calorimetry. Int. J. Pharm. 180 (1999) 83-90
10. Menard K.P. Dynamic Mechanical Analysis: A Practical Introduction (1999), CRC Press, London
11. Pijpers T.F.J., Mathot V.B.F., Goderis B., Scherrenberg R.L., and van der Vegte E.W. High-speed calorimetry for the study of the kinetics of (De)vitrification, crystallization, and melting of macromolecules. Macromolecules 35 (2002) 3601-3613
12. Price D.M. In: Haines J. (Ed). Principles of Thermal Analysis and Calorimetry (2002), Royal Society of Chemistry, Cambridge
13. Royall P.G., Huang C.Y., Tang S.W.J., Duncan J., Van-de-Velde G., and Brown M.B. The development of DMA for the detection of amorphous content in pharmaceutical powdered materials. Int. J. Pharm. 301 (2005) 181-191