Diabetic retinopathy is associated with early autonomic dysfunction assessed by exercise-related heart rate changes

Brazilian Journal of Medical and Biological Research

Volumn 41, Issue 12, 2008, Pages 1110-1115

  Kramer, C K ^a   Leitao C B ^a   Azevedo, M J ^a   Valiatti, F B ^b   Rodrigues, T C ^a   Canarii, L H ^a   Gross, J L ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b Hospital Banco de Olhos de Porto Alegre   (Brazil)

Author keywords

Diabetic retinopathy; Heart rate changes; Type 1 diabetes mellitus; Type 2 diabetes mellitus

Indexed keywords

HEMOGLOBIN A1C;

ADULT; ARTICLE; AUTONOMIC DYSFUNCTION; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETIC RETINOPATHY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE DURATION; EXERCISE ELECTROCARDIOGRAPHY; FEMALE; HEART RATE VARIABILITY; HEMOGLOBIN BLOOD LEVEL; HIGH RISK PATIENT; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OPHTHALMOSCOPY; RISK ASSESSMENT;

EID: 62749168288     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2008001200011     Document Type: Article

References (25)

1. UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 1998; 317: 703-713.
2. da Costa Rodrigues T, Pecis M, Azevedo MJ, Esteves JF, Gross JL. Ambulatory blood pressure monitoring and progression of retinopathy in normotensive, normoalbuminuric type 1 diabetic patients: a 6-year follow-up study. Diabetes Res Clin Pract 2006; 74: 135-140.
3. Krolewski AS, Barzilay J, Warram JH, Martin BC, Pfeifer M, Rand LI. Risk of early-onset proliferative retinopathy in IDDM is closely related to cardiovascular autonomic neuropathy. Diabetes 1992; 41: 430-437.
4. Smith SE, Smith SA, Brown PM. Cardiac autonomic dysfunction in patients with diabetic retinopathy. Diabetologia 1981; 21: 525-528.
5. Shetler K, Marcus R, Froelicher VF, Vora S, Kalisetti D, Prakash M, et al. Heart rate recovery: validation and methodologic issues. J Am Coll Cardiol 2001; 38: 1980-1987.
6. Ogoh S, Fisher JP, Dawson EA, White MJ, Secher NH, Raven PB. Autonomic nervous system influence on arterial baroreflex control of heart rate during exercise in humans. J Physiol 2005; 566: 599-611.
7. Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS. Heart-rate recovery immediately after exercise as a predictor of mortality. N Engl J Med 1999; 341: 1351-1357.
8. Cole CR, Foody JM, Blackstone EH, Lauer MS. Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort. Ann Intern Med 2000; 132: 552-555.
9. Jouven X, Empana JP, Schwartz PJ, Desnos M, Courbon D, Ducimetiere P. Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med 2005; 352: 1951-1958.
10. Standards of medical care in diabetes - 2007. Diabetes Care 2007; 30 (Suppl 1): S4-S41.
11. Leitao CB, Canani LH, Kramer CK, Boza JC, Pinotti AF, Gross JL. Masked hypertension, urinary albumin excretion rate, and echocardiographic parameters in putatively normotensive type 2 diabetic patients. Diabetes Care 2007; 30: 1255-1260.
12. Canani LH, Gerchman F, Gross JL. Increased familial history of arterial hypertension, coronary heart disease, and renal disease in Brazilian type 2 diabetic patients with diabetic nephropathy. Diabetes Care 1998; 21: 1545-1550.
13. Wilkinson CP, Ferris FL III, Klein RE, Lee PP, Agardh CD, Davis M, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 2003; 110: 1677-1682.
14. Boelter MC, Gross JL, Canani LH, Costa LA, Lisboa HR, Tres GS, et al. Proliferative diabetic retinopathy is associated with microalbuminuria in patients with type 2 diabetes. Braz J Med Biol Res 2006; 39: 1033-1039.
15. Fletcher GF, Balady G, Froelicher VF, Hartley LH, Haskell WL, Pollock ML. Exercise standards. A statement for health care professionals from the American Heart Association. Writing Group. Circulation 1995; 91: 580-615.
16. Ewing DJ, Campbell IW, Clarke BF. Assessment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications. Ann Intern Med 1980; 92: 308-311.
17. Pecis M, Azevedo MJ, Moraes RS, Ferlin EL, Gross JL. Autonomic dysfunction and urinary albumin excretion rate are associated with an abnormal blood pressure pattern in normotensive normoalbuminuric type 1 diabetic patients. Diabetes Care 2000; 23: 989-993.
18. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
19. Maguire AM, Craig ME, Craighead A, Chan AK, Cusumano JM, Hing SJ, et al. Autonomic nerve testing predicts the development of complications: a 12-year follow-up study. Diabetes Care 2007; 30: 77-82.
20. Imano E, Miyatsuka T, Motomura M, Kanda T, Matsuhisa M, Kajimoto Y, et al. Heart rate elevation and diabetic retinopathy in patients with type 2 diabetes mellitus and normoalbuminuria. Diabetes Res Clin Pract 2001; 52: 185-191.
21. La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A, Schwartz PJ. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 1998; 351: 478-484.
22. Potts JT, Shi XR, Raven PB. Carotid baroreflex responsiveness during dynamic exercise in humans. Am J Physiol 1993; 265: H1928-H1938.
23. Lind L, Andren B. Heart rate recovery after exercise is related to the insulin resistance syndrome and heart rate variability in elderly men. Am Heart J 2002; 144: 666-672.
24. Androne AS, Hryniewicz K, Goldsmith R, Arwady A, Katz SD. Acetylcholinesterase inhibition with pyridostigmine improves heart rate recovery after maximal exercise in patients with chronic heart failure. Heart 2003; 89: 854-858.
25. Nielsen FS, Hansen HP, Jacobsen P, Rossing P, Smidt UM, Christensen NJ, et al. Increased sympathetic activity during sleep and nocturnal hypertension in type 2 diabetic patients with diabetic nephropathy. Diabet Med 1999; 16: 555-562.