Nephrotic syndrome: New concepts in the pathophysiology of sodium retention

Journal of Nephrology

Volumn 21, Issue 6, 2008, Pages 836-842

  Zacchia, Miriam ^a   Trepiccione, Francesco ^a   Morelli, Franco ^b   Pani, Antonello ^c   Capasso, Giovambattista ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^c BROTZU HOSPITAL   (Italy)

Author keywords

Aldosterone; Amiloride; K+ ATPase; Na+; Nephrotic syndrome; Sodium channels

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMILORIDE; EPITHELIAL SODIUM CHANNEL; FUROSEMIDE; SODIUM POTASSIUM 2 CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG; VASOPRESSIN; SODIUM; SODIUM CHANNEL;

EDEMA; FLUID BALANCE; FLUID RETENTION; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; GLOMERULUS FILTRATION RATE; HORMONE ACTION; HUMAN; IMMUNOCYTOCHEMISTRY; NEPHRON; NEPHROTIC SYNDROME; NONHUMAN; OSMOTIC PRESSURE; PATHOGENESIS; REVIEW; SODIUM ABSORPTION; SODIUM RETENTION; SODIUM TRANSPORT; SODIUM URINE LEVEL; ANIMAL; ION TRANSPORT; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; HUMANS; ION TRANSPORT; NEPHRONS; NEPHROTIC SYNDROME; SODIUM; SODIUM CHANNELS;

EID: 62749160909     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Gorgieva GS. Kidney disease in medieval Serbian manuscripts from the Chilandar monastery (Mount Athos, Greece). J Nephrol. 2006;19(Suppl 10):S30-S37.
2. Cameron JS. Milk or albumin? The history of proteinuria before Richard Bright. Nephrol Dial Transplant. 2003;18:1281-1285.
3. Schena FP. The role of Domenico Cotugno in the history of proteinuria. Nephrol Dial Transplant. 1994;9:1344-1345.
4. Bright R. Gulstonian Lectures on the functions of the abdominal viscera with observations on the diagnostic marks of the diseases to which the viscera are subject." London Medical Gazette. 1832;12:281-287.
5. Muller F. Morbus brightii. Verhandl Dtsch Pothol Gesell. 1905;9:64-99.
6. Cameron JS, Hicks J. The origins and development of the concept of a "nephritic syndrome." Am J Nephrol. 2002;22:240-247.
7. Rasool A, Palevsky PM. Treatment of edematous disorders with diuretics. Am J Med Sci. 2000;319:25-37.
8. Doucet A, Favre G, Deschenes G. Molecular mechanism of edema formation in nephrotic syndrome: therapeutic implications. Pediatr Nephrol. 2007;22:1983-1990.
9. Glassock RJ. Cytotoxic drugs in primary glomerular disease. Proc Clin Dial Transplant Forum. 1974;(4):83-5.
10. Epstein AA. Concerning the causation of edema in chronic parenchymatous nephritis; method for its alleviation. Am J Med. 1952;13:556-561.
11. DiBona GF, Sawin LL, Jones SY. Characteristics of renal sympathetic nerve activity in sodium-retaining disorders. Am J Physiol. 1996;271:R295-R302.
12. Pedersen EB, Danielsen H, Madsen M, Jensen T. Defective renal water excretion in nephrotic syndrome: the relationship between renal water excretion and kidney function, arginine vasopressin, angiotensin II and aldosterone in plasma before and after oral water loading. Eur J Clin Invest. 1985;15:24-29.
13. Usberti M, Federico S, Meccariello S, et al. Role of plasma vasopressin in the impairment of water excretion in nephrotic syndrome. Kidney Int. 1984;25:422-429.
14. Koot BG, Houwen R, Pot DJ, Nauta J. Congenital analbuminaemia: biochemical and clinical implications: a case report and literature review. Eur J Pediatr. 2004;163:664-670.
15. Vande Walle JG, Donckerwolcke RA, van Isselt JW, Derkx FH, Joles JA, Koomans HA. Volume regulation in children with early relapse of minimal-change nephrosis with or without hypovolaemic symptoms. Lancet. 1995;346:148-152.
16. Usberti M, Gazzotti RM. Hyporeninemic hypoaldosteronism in patients with nephrotic syndrome. Am J Nephrol. 1998;18:251-255.
17. Peterson OW, Gushwa LC, Blantz RC. An analysis of glomerular-tubular balance in the rat proximal tubule. Pflugers Arch. 1986;407:221-227.
18. + channel of the thick ascending limb of Henle's loop. Pfluegers Arch. 1990; 415:449-460.
19. Steinmeyer K, Jentsch TJ. Molecular physiology of renal chloride channels. Curr Opin Nephrol Hypertens. 1998;7:497-502.
20. Greger R. Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron. Physiol Rev. 1985;65:760-795.
21. Knoers NV, de Jong JC, Meij IC, Van Den Heuvel LP, Bindels RJ. Genetic renal disorders with hypomagnesemia and hypocalciuria. J Nephrol. 2003;16:293-296.
22. Barakat AJ, Rennert OM. Gitelman's syndrome (familial hypokalemia-hypomagnesemia). J Nephrol. 2001;14:43-47.
23. Andreoli TE. An overview of salt absorption by the nephron. J Nephrol. 1999;12(Suppl 2):S3-S15.
24. Canessa CM, Horisberger J, Schild L, Rossier BC. Expression cloning of the epithelial sodium channel. Kidney Int. 1995;48:950-955.
25. Ichikawa I, Rennke HG, Hoyer JR, et al. Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome. J Clin Invest. 1983;71:91-103.
26. Deschenes G, Doucet A. Collecting duct (Na+/K+)-ATPase activity is correlated with urinary sodium excretion in rat nephrotic syndromes. J Am Soc Nephrol. 2000;11:604-615.
27. Vinciguerra M, Deschenes G, Hasler U, et al. Intracellular Na+ controls cell surface expression of Na,K-ATPase via a cAMP-independent PKA pathway in mammalian kidney collecting duct cells. Mol Biol Cell. 2003;14:2677-2688.
28. Kim SW, Wang W, Nielsen, J et al. Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats. Am J Physiol Renal Physiol. 2004;286:F922-F935.
29. Fernandez-Llama P, Ageloff S, Fernandez-Varo G, et al. Sodium retention in cirrhotic rats is associated with increased renal abundance of sodium transporter proteins. Kidney Int. 2005;67:622-630.
30. Thiesson HC, Jensen BL, Bistrup C, et al. Renal sodium retention in cirrhotic rats depends on glucocorticoid-mediated activation of mineralocorticoid receptor due to decreased renal 11beta-HSD-2 activity. Am J Physiol Regul Integr Comp Physiol. 2007;292:R625-R636.
31. Andreoli TE. Pathogenesis of renal sodium retention in congestive heart failure. Miner Electrolyte Metab. 1999;25:11-20.
32. Deschenes G, Wittner M, Stefano A, Jounier S, Doucet A. Collecting duct is a site of sodium retention in PAN nephrosis: a rationale for amiloride therapy. J Am Soc Nephrol. 2001;12:598-601.
33. Lourdel S, Loffing J, Favre G, et al. Hyperaldosteronemia and activation of the epithelial sodium channel are not required for sodium retention in puromycin-induced nephrosis. J Am Soc Nephrol. 2005;16:3642-3650.
34. de Seigneux S, Kim SW, Hemmingsen SC, Frøkiaer J, Nielsen S. Increased expression but not targeting of ENaC in adrenalectomized rats with PAN-induced nephrotic syndrome. Am J Physiol Renal Physiol. 2006;291:F208-F217.
35. Pyo HJ, Summer SN, Niederberger M, Kim JK, Schrier RW. Arginine vasopressin gene expression in rats with puromycin-induced nephrotic syndrome. Am J Kidney Dis. 1995;25:58-62.
36. Sala C, Bedogna V, Gammaro L, Valvo E, Del BA, Morganti A. Central role of vasopressin in sodium/water retention in hypo- and hypervolemic nephrotic patients: a unifying hypothesis. J Nephrol. 2004;17:653-657.
37. Klisic J, Zhang J, Nief V, Reyes L, Moe OW, Ambuhl PM. Albumin regulates the Na+/H+ exchanger 3 in OKP cells. J Am Soc Nephrol. 2003;14:3008-3016.
38. Rascher W, Tulassay T. Hormonal regulation of water metabolism in children with nephrotic syndrome. Kidney Int Suppl. 1987;21:S83-S89.
39. Usberti M, Gazzotti RM, Poiesi C, D'Avanzo L, Ghielmi S. Considerations on the sodium retention in nephrotic syndrome. Am J Nephrol. 1995;15:38-47.
40. Deschenes G, Guigonis V, Doucet A. [Molecular mechanism of edema formation in nephrotic syndrome] [article in French]. Arch Pediatr. 2004;11:1084-1094.