Nandrolone decanoate administration dose-dependently affects the density of kappa opioid peptide receptors in the rat brain determined by autoradiography

Neuropeptides

Volumn 43, Issue 2, 2009, Pages 105-111

  Magnusson, K ^a   Birgner, C ^a   Bergstrom L ^a   Nyberg, F ^a   Hallberg, M ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Anabolic androgenic steroids (AAS); Autoradiography; Brain; Kappa opioid peptide receptor (KOP receptor); Rat

Indexed keywords

KAPPA OPIATE RECEPTOR; NANDROLONE DECANOATE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN REGION; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; GLOBUS PALLIDUS; HYPOTHALAMUS NUCLEUS; LATERAL HYPOTHALAMUS; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRIA TERMINALIS; UPREGULATION; ZONA INCERTA;

ANABOLIC AGENTS; ANIMALS; AUTORADIOGRAPHY; BRAIN CHEMISTRY; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DYNORPHINS; MALE; NANDROLONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA;

RATTUS;

EID: 62749121529     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2008.12.005     Document Type: Article

References (43)

1. Arvidsson U., et al. The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids. Proc. Nat. Acad. Sci. USA 92 (1995) 5062-5066
2. Beadles-Bohling A.S., and Wiren K.M. Alteration of kappa-opioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity. Brain Res. 1046 (2005) 77-89
3. Bhargava H.N., et al. Effect of chronic administration of U-50, 488H on tolerance to its pharmacological actions and on multiple opioid receptors in rat brain regions and spinal cord. J. Pharmacol. Exp. Ther. 251 (1989) 21-26
4. Birgner C., et al. Altered extracellular levels of DOPAC and HVA in the rat nucleus accumbens shell in response to sub-chronic nandrolone administration and a subsequent amphetamine challenge. Neurosci. Lett. 412 (2007) 168-172
5. Brower K.J., et al. Symptoms and correlates of anabolic-androgenic steroid dependence. Br. J. Addict. 86 (1991) 759-768
6. Butelman E.R., et al. Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic kappa-opioid agonists in rhesus monkeys. Psychoneuroendocrinology 29 (2004) 307-326
7. Carlezon Jr. W.A., et al. Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. J. Pharmacol. Exp. Ther. 316 (2006) 440-447
8. Collins S., et al. Regulation of dynorphin gene expression by kappa-opioid agonist treatment. Neuroreport 13 (2002) 107-109
9. Costigan M., and Woolf C.J. No DREAM, No pain. Closing the spinal gate. Cell 108 (2002) 297-300
10. Fan L.W., et al. Withdrawal from dependence upon butorphanol uniquely increases kappa(1)-opioid receptor binding in the rat brain. Brain Res. Bull. 58 (2002) 149-160
11. Ford C.P., et al. Kappa opioid inhibition of somatodendritic dopamine inhibitory postsynaptic currents. J. Neurophysiol. 97 (2007) 883-891
12. Fuentealba J.A., et al. Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases stimulated dopamine extracellular levels in the rat nucleus accumbens. J. Neurosci. Res. 84 (2006) 450-459
13. Goodman R.L., et al. Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep. Endocrinology 145 (2004) 2959-2967
14. Hollt V. Opioid peptide processing and receptor selectivity. Annu. Rev. Pharmacol. Toxicol. 26 (1986) 59-77
15. Johansson P., et al. The effect on opioid peptides in the rat brain, after chronic treatment with the anabolic androgenic steroid, nandrolone decanoate. Brain Res. Bull. 51 (2000) 413-418
16. Johansson P., et al. Anabolic androgenic steroids affect alcohol intake, defensive behaviors and brain opioid peptides in the rat. Pharmacol. Biochem. Behav. 67 (2000) 271-279
17. Johansson-Steensland P., et al. The anabolic androgenic steroid, nandrolone decanoate, increases the density of Fos-like immunoreactive neurons in limbic regions of guinea-pig brain. Eur. J. Neurosci. 15 (2002) 539-544
18. Kindlundh A.M., et al. The anabolic-androgenic steroid nandrolone induces alterations in the density of serotonergic 5HT1B and 5HT2 receptors in the male rat brain. Neuroscience 119 (2003) 113-120
19. Kitchen I., et al. Quantitative autoradiographic mapping of mu-, delta- and kappa-opioid receptors in knockout mice lacking the mu-opioid receptor gene. Brain Res. 778 (1997) 73-88
20. Klintenberg R., and Andren P.E. Altered extracellular striatal in vivo biotransformation of the opioid neuropeptide dynorphin A(1-17) in the unilateral 6-OHDA rat model of Parkinson's disease. J. Mass Spectrom. 40 (2005) 261-270
21. Kolesnikov Y., et al. Peripheral kappa 1-opioid receptor-mediated analgesia in mice. Eur. J. Pharmacol. 310 (1996) 141-143
22. Lukas S.E. CNS effects and abuse liability of anabolic-androgenic steroids. Annu. Rev. Pharmacol. Toxicol. 36 (1996) 333-357
23. Magnusson K., et al. Enzymatic conversion of dynorphin A in the rat brain is affected by administration of nandrolone decanoate. Peptides. 28 (2007) 851-858
24. Mansour A., et al. Kappa 1 receptor mRNA distribution in the rat CNS: comparison to kappa receptor binding and prodynorphin mRNA. Mol Cell Neurosci. 5 (1994) 124-144
25. Mansour A., et al. Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain. J Neurosci. 7 (1987) 2445-2464
26. McLaughlin J.P., et al. Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. Neuropsychopharmacology. 31 (2006) 1241-1248
27. Ogura M., and Kita H. Dynorphin exerts both postsynaptic and presynaptic effects in the Globus pallidus of the rat. J Neurophysiol. 83 (2000) 3366-3376
28. Palkovits M. Stress-induced expression of co-localized neuropeptides in hypothalamic and amygdaloid neurons. Eur J Pharmacol. 405 (2000) 161-166
29. Paxinos G.W.C. The rat brain in stereotaxiccoordinates vol. Academic press (1997), San Diego, CA, USA
30. Pfeiffer A., et al. Psychotomimesis mediated by kappa opiate receptors. Science. 233 (1986) 774-776
31. Rattan A.K., et al. The effect of morphine tolerance dependence and abstinence on immunoreactive dynorphin (1-13) levels in discrete brain regions, spinal cord, pituitary gland and peripheral tissues of the rat. Brain Res. 584 (1992) 207-212
32. Rocha V.M., et al. Influence of anabolic steroid on anxiety levels in sedentary male rats. Stress. 10 (2007) 326-331
33. Shuster S.J., et al. Stimulus-dependent translocation of kappa opioid receptors to the plasma membrane. J Neurosci. 19 (1999) 2658-2664
34. Simerly R.B., et al. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol. 294 (1990) 76-95
35. Simonin F., et al. Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50, 488H and attenuates morphine withdrawal. Embo J. 17 (1998) 886-897
36. Su T.P., et al. Neuropsychiatric effects of anabolic steroids in male normal volunteers. Jama. 269 (1993) 2760-2764
37. Svingos A.L., et al. Cellular sites for dynorphin activation of kappa-opioid receptors in the rat nucleus accumbens shell. J Neurosci. 19 (1999) 1804-1813
38. Unterwald E.M., et al. Neuroanatomical localization of kappa 1 and kappa 2 opioid receptors in rat and guinea pig brain. Brain Res. 562 (1991) 57-65
39. Wagner E.J., et al. Neurochemical evidence that estrogen-induced suppression of kappa-opioid-receptor-mediated regulation of tuberoinfundibular dopaminergic neurons is prolactin-independent. Neuroendocrinology. 59 (1994) 197-201
40. Wittmann W., et al. Prodynorphin-Derived Peptides Are Critical Modulators of Anxiety and Regulate Neurochemistry and Corticosterone. Neuropsychopharmacology (2008)
41. Wood R.I., et al. Testosterone reinforcement: intravenous and intracerebroventricular self-administration in male rats and hamsters. Psychopharmacology (Berl). 171 (2004) 298-305
42. Yukhananov R.Y., and Handa R.J. Alterations in kappa opioid receptor mRNA levels in the paraventricular nucleus of the hypothalamus by stress and sex steroids. Neuroreport. 7 (1996) 1690-1694
43. Zhang Y., et al. Effect of the endogenous kappa opioid agonist dynorphin A(1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology (Berl). 172 (2004) 422-429